Protein Alignment tim and tim-1

DIOPT Version :10

• Sequence 1: NP_001334730.1
• Gene: tim / 33571
• FlyBaseID: FBgn0014396
• Length: 1421
• Species: Drosophila melanogaster
• Sequence 2: NP_499594.2
• Gene: tim-1 / 176652
• WormBaseID: WBGene00006571
• Length: 1353
• Species: Caenorhabditis elegans
• Alignment Length: 1475
• Identity: 253/1475 - (17%)
• Similarity: 473/1475 - (32%)
• Gaps: 547/1475 - (37%)

  Fly    36 AFSSLGCLEGDTYVVNPNALAILEEINYKLTY--EDQTLRTFRRAIGFGQNVRSDLIPLL--ENA 96
            |..:||..|...|...|:.   .|.|...:.|  ||....|.|...|....|..||:|::  |:.
 Worm     8 AVHALGYYEDGKYSREPDC---YESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDL 69

  Fly    97 KDDAVLESVIRILVNLTVPVECLFSVDVMY-RTDVGR---HTIFELNKLLYTSKEAFTEARSTKS 157
            .||. .:..||::|||..|     ::..|. :....|   ...:||.:.|..:|.||::|....:
 Worm    70 TDDE-FDIAIRLMVNLCQP-----AISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTA 128

  Fly   158 VVEYMKHIL------ESDPKLSPHKCDQINNCLLLLRNILHI-PET------------HAHCVMP 203
            :.:.:.:..      :.|.:|..    .:...:||::.:..| |:|            |...::.
 Worm   129 IKKRIDNYFIDTEYEDRDERLRL----VVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIA 189

  Fly   204 MMQSMPHGISMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLS 268
            .::|                  .|||.|:::...|:...:.||::.:.|||.|:|....|
 Worm   190 FLES------------------GIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDL----- 231

  Fly   269 LWFEASLSESSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEV 333
                     :::..|.:|:..|:...:...::.:....::....|..| .||..   |...|:.:
 Worm   232 ---------ATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSR-FGGSY---TIKGLKGI 283

  Fly   334 SRKGQEYQNAMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEH 398
            |                            .|.|:....|.|:......:||        |:..:.
 Worm   284 S----------------------------ANSSQVVFKPIQNVEKHNFLDD--------RKAKKR 312

  Fly   399 GEEDEDEDEVEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRA 463
            ...:....|::...:.   .:||...:.:....::..|          |...        |...:
 Worm   313 APRNRRPFEIDTNSHF---ASSEVRGMLRDMVIRIIET----------CFNR--------LMKSS 356

  Fly   464 STSAHAQMQKFNESSYASHVSAVK------------------LGQKSPHAGQLQLTKGKCCPQKR 510
            .|:...|:||.::.:|...:..|.                  :|.::.|...:|||:
 Worm   357 KTTVFVQVQKTSQINYFFLIKFVLRFVRLSRQDHLLERISECIGVEAFHENNVQLTE-------- 413

  Fly   511 ECPSSQSELSDCGYGTQVENQESISTSSNDDDGPQGKPQHQKPPCNTKPRNK----PRTIMSPMD 571
                            .|||..::.       |.:.|....|........|:    .|.|..  .
 Worm   414 ----------------YVENATTLK-------GVEAKSHGLKAQYALGAYNELVLLHRYIYE--H 453

  Fly   572 KKELRRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSN-- 634
            .||...:|..||:...::|::.              .:|..: |::|.:|       ..:|||
 Worm   454 AKEENERKFAKRALEHIVNVEE--------------YRELPI-FIIKKFS-------SSVLSNNF 496

  Fly   635 -AKVPIDTSHFFWLVTYFLKFAA--------------------------------QLELD----- 661
             .::.:.|.|:..||..|:|..|                                :.:||
 Worm   497 LRELVLTTHHYMKLVERFVKTGALKKVTKKVKVRKATKKSKMSEEDVRSEFDGMSKKDLDRLWEE 561

  Fly   662 ------------------MEHIDTILTYDVLSYLTYEGVSL------------------------ 684
                              |..||:.|...|.:...:..:|:
 Worm   562 SKGLVLQILKKEVPEMRGMNPIDSQLDVPVDAQQKFAKLSIQRSLRSRGFPAAVGLYHASRALWP 626

  Fly   685 ----------------------CEQ-LELNARQEGSDLK------------PYLRRMHLVVTAIR 714
                                  .|| |:.:.::...|||            .|.:...:..||::
 Worm   627 ESFKRGLTDFQDSPGEEDQLQELEQLLKADMKKVAKDLKKAESCKTCDEDPAYKKYDKMDATALQ 691

  Fly   715 E-FLQAIDTYNKV-TH-LNEDDKAHLRQLQLQISEMSDLRCLFVLL-----LR-RFNPS----IH 766
            . :.|:.||..:: :| |.|.:.......||.|:  .|::..|.:|     || |..|:    .|
 Worm   692 SLWEQSTDTLARILSHELPESESTSPVNWQLDIT--PDVQQKFAMLAIQRALRARDLPAAVGLYH 754

  Fly   767 SKQYL----------------QDLVVTNHILLLILDSSAKLGGCQTIRLSE-------------- 801
            :.:.|                :::.....||...|...|:     .::::|
 Worm   755 TSRKLWPGDEAIFGAPGIGVEEEIAELKAILEADLHEVAR-----EMKVAEDRAEDPDEEDPAEP 814

  Fly   802 -------------------------HITQFATLEVMHYYGILLEDFNNNGEFVNDCIFTMMHHIG 841
                                     ::.:|:.::|:.:|..||.||:.|...:|..:..|:|.|.
 Worm   815 YDSEQEEEEEVPAWKVEEIDFQFDSYVCKFSNVDVLKWYVFLLNDFSKNSTELNQALVKMLHRIA 879

  Fly   842 GDLGQIGVLFQPIILKTYSRIWEADYELCDDW---SDLIE------YVIHKFMN----------- 886
            .||.....|:|..:.:.:|::.|....|..|.   |.|.|      :::.||.:
 Worm   880 FDLKLPIKLYQVSLFQVFSKVNEHFTHLSKDLRKSSRLYELYQFGFHLLKKFFSKFTGDLAIEAL 944

  Fly   887 --TPPKSPLTIPTTSLTEMTKEHNQEHTVCSWSQE---EMDTLYWYYVQSKKNNDIVGKIVKLFS 946
              ..|:....| ........|  ::|..:..|:::   |:..||..|...:..:.|  .::....
 Worm   945 FWKGPRECFEI-ENGYGSWVK--SREADIRVWTEDLEIELRNLYEEYRTMETRDGI--DVLDFIE 1004

  Fly   947 NNGNKLKTRISIIQQLLQQDIITLLEYDDLM--KFEDAEYQRTLLTTPTSATTESGIEIKECAYG 1009
            :|.::.::|..:.::|::...       ||:  |:::::..|.....|.....:...|.||.  |
 Worm  1005 HNLSRARSRKKVAKKLIEFGF-------DLLGAKWKNSDKARMDSVLPIGDIQKWYDEWKEA--G 1060

  Fly  1010 KPSDDVQILLDLIIKENKAQHLLWLQRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCIC---- 1070
            ...|.|.:|.:                        ||....|:::.. ..|::.:|:..|.
 Worm  1061 ARGDLVNVLQE------------------------KLNEDLGMEISR-KKILKQLAHMDILYEKP 1100

  Fly  1071 -KQKSIPVVQWN----------NEQSTTMLYQPFVLLLHKLGI-----------------QLPAD 1107
             |:|.:|  ||:          .||     |......|:.||:                 |:...
 Worm  1101 KKEKPLP--QWDTGLIEELKKLKEQ-----YDDIPDALNMLGVNIVRYVMKRLSEKKPTRQVERH 1158

  Fly  1108 AGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSPSRYHHTGPRNSLSSVSSL 1172
            ..|:.|.||:         .:||   .:|...|||....:|...|          .|.:...|..
 Worm  1159 LESLGATIPE---------RSKK---SEKNGKKFDDFLNDDDDDS----------ENDVGGGSED 1201

  Fly  1173 DVDLGDTEELA-----LIP---------EVDAAVEKAHAMASTPS 1203
            |    :.||:.     :||         |.:.|.:|...:|..|:
 Worm  1202 D----EEEEIVMKSKRIIPDSEDEEEHIEQEEAQKKLEKVAEKPN 1242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tim	NP_001334730.1	TIMELESS	47..305	CDD:461444	57/284 (20%)
		TIMELESS_C	1018..1125	CDD:461529	23/138 (17%)
tim-1	NP_499594.2	TIMELESS	19..277	CDD:461444	61/306 (20%)