Protein Alignment HTR2B and htr2b

DIOPT Version :10

• Sequence 1: NP_000858.3
• Gene: HTR2B / 3357
• HGNCID: 5294
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001038208.1
• Gene: htr2b / 751784
• ZFINID: ZDB-GENE-081022-57
• Length: 443
• Species: Danio rerio
• Alignment Length: 437
• Identity: 275/437 - (62%)
• Similarity: 348/437 - (79%)
• Gaps: 18/437 - (4%)

Human    55 HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 119
            ||||||||:||:||||||.|||||||||:|||.|||:||||||||||||||.||||||:|:::.:
Zfish    15 HWAALLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTVLYNS 79

Human   120 MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISI 184
            .|||...|||.||||||||||||||||||||:|||||||||||.:|:.|||....||.:||||||
Zfish    80 TWPLADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVWLISI 144

Human   185 GIAIPVPIKGIETDVDNPN-----NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHAL 244
            |||||:||||::. .|:||     |.||:|:.|.|.||.::|||.|||.|||||::.|.|||..|
Zfish   145 GIAIPIPIKGLQF-FDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIMMIIYLLTIQVL 208

Human   245 QKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKAL----PNSGDETLMRRT 305
            :|||||::::..:.    ::|||||::.:..:||||:.:.:|.::|:.|    |.:|||..:||.
Zfish   209 RKKAYLLRSRAARP----SISTVFQQELSVLASPEKMVISNGIKRDRTLNPVNPITGDEVPLRRM 269

Human   306 STIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGY 370
            |||||:|:|.::|||||||||||||.||::|||||||||:|.|||:.||...:..||:||.|:||
Zfish   270 STIGKRSMQNLTNEQRASKVLGIVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLDIFQWVGY 334

Human   371 VSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLR-KRSSKIYFRNPMAENSKFFKKHGIR 434
            ||||:|||||||||:|||.||.|||||||   |||:|.: :|.|||.||:.:.||||.|.|||::
Zfish   335 VSSGINPLVYTLFNRTFRLAFRRYITCNY---KSVRTPKLQRRSKISFRSSVTENSKRFMKHGMK 396

Human   435 NGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV 481
            |||:|..||||:|.||:.:|:|:.|:|||||||:||..|.:|.||:|
Zfish   397 NGISPVGYQSPIRHRSTQLQTSANIMLDTLLLTDNEDCKPDEHVSHV 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2B	NP_000858.3	7tmA_5-HT2B	55..398	CDD:341347	226/351 (64%)
		TM helix 1	56..82	CDD:341347	22/25 (88%)
		TM helix 2	89..115	CDD:341347	22/25 (88%)
		TM helix 3	128..158	CDD:341347	27/29 (93%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	152..154		1/1 (100%)
		TM helix 4	170..193	CDD:341347	15/22 (68%)
		[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	212..215		1/2 (50%)
		TM helix 5	214..243	CDD:341347	18/28 (64%)
		TM helix 6	317..347	CDD:341347	24/29 (83%)
		TM helix 7	359..384	CDD:341347	18/24 (75%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	376..380		3/3 (100%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294	479..481		1/1 (100%)
htr2b	NP_001038208.1	7tm_GPCRs	15..362	CDD:475119	226/351 (64%)
		TM helix 1	17..41	CDD:410628	20/23 (87%)
		TM helix 2	50..72	CDD:410628	19/21 (90%)
		TM helix 3	89..111	CDD:410628	20/21 (95%)
		TM helix 4	134..150	CDD:410628	12/15 (80%)
		TM helix 5	179..202	CDD:410628	13/22 (59%)
		TM helix 6	287..309	CDD:410628	18/21 (86%)
		TM helix 7	323..348	CDD:410628	18/24 (75%)