DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2B and 5-HT2B

DIOPT Version :10

Sequence 1:NP_000858.3 Gene:HTR2B / 3357 HGNCID:5294 Length:481 Species:Homo sapiens
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:938 Identity:167/938 - (17%)
Similarity:265/938 - (28%) Gaps:524/938 - (55%)


- Green bases have known domain annotations that are detailed below.


Human     9 ELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNT 73
            |.|.|......:...:||  :.|:.....:|....:.:..:..|  :| |||.|::::.|..||.
  Fly    33 ETQRTTANATSRHNQLHV--ARWNATGNATISATFEDVPFDANN--YW-ALLALVLVLGTAAGNI 92

Human    74 LVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLF 138
            ||.||::.|::||..|||||||||:.||:|.:.|||:.:||:: :..:||....|..|:.|||||
  Fly    93 LVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGYFPLGSEHCLTWICLDVLF 156

Human   139 STASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPN 203
            .||||||||.||||||::::.|::..:..:|....:||..|||:||.:::|:.:...:.......
  Fly   157 CTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLV 221

Human   204 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAY------------------- 249
            |.||.:...   .:.|.||:..|:.||.:|::||.||:..|.::..                   
  Fly   222 NGTCQIPDP---VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGW 283

Human   250 ---------------LVKNKP-------------------------------------------- 255
                           |:|..|                                            
  Fly   284 LGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTA 348

Human   256 ---------------------------------------------PQR----------------- 258
                                                         |||                 
  Fly   349 LHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHP 413

Human   259 ---------------LTWLTVSTV---FQRD---------------------------------- 271
                           .|.|.:||.   .:|:                                  
  Fly   414 AGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRR 478

Human   272 ----------------------ETP---------------------------------------- 274
                                  |||                                        
  Fly   479 RASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESA 543

Human   275 ---------------------------------------------------------C------- 275
                                                                     |       
  Fly   544 QQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVK 608

Human   276 ----------------SSPEKVAML---------------------------------------- 284
                            |||.::.:|                                        
  Fly   609 IISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAH 673

Human   285 ----------DGS-------------RK-----------------------------------DK 291
                      |||             ||                                   .|
  Fly   674 NQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTK 738

Human   292 ALPNSGDETLMRRTSTI--------------GKKSVQTISN------------------------ 318
            ....|...|.:||::|:              |.|:..|.|:                        
  Fly   739 TATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRN 803

Human   319 ----------EQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSS 373
                      ||:|:||||:|||.|:::|.|||:.|:...:|..|.:.....:.::..|:||.||
  Fly   804 SSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASS 868

Human   374 GVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGIN 438
            .|||:.||:|||.||.||.:.:.|.|.:|.:.:                                
  Fly   869 MVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWR-------------------------------- 901

Human   439 PAMYQSPM---RLRSSTIQSSSIILLDT 463
            |:. |:|:   :|:::|.:.:|:...|:
  Fly   902 PSRXQTPVKPGKLKTNTHKCASVDFQDS 929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2BNP_000858.3 7tmA_5-HT2B 55..398 CDD:341347 149/822 (18%)
TM helix 1 56..82 CDD:341347 12/25 (48%)
TM helix 2 89..115 CDD:341347 16/25 (64%)
TM helix 3 128..158 CDD:341347 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538 152..154 1/1 (100%)
TM helix 4 170..193 CDD:341347 8/22 (36%)
[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538 212..215 0/2 (0%)
TM helix 5 214..243 CDD:341347 11/28 (39%)
TM helix 6 317..347 CDD:341347 17/63 (27%)
TM helix 7 359..384 CDD:341347 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538 376..380 2/3 (67%)
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294 479..481
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 81/199 (41%)
TM helix 1 75..101 CDD:320433 12/26 (46%)
TM helix 2 108..134 CDD:320433 16/25 (64%)
TM helix 3 146..176 CDD:320433 21/29 (72%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 11/31 (35%)
7tm_GPCRs <799..893 CDD:475119 35/93 (38%)
TM helix 6 818..840 CDD:410628 12/21 (57%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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