Protein Alignment HTR2B and ser-1

DIOPT Version :10

• Sequence 1: NP_000858.3
• Gene: HTR2B / 3357
• HGNCID: 5294
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001024728.1
• Gene: ser-1 / 181716
• WormBaseID: WBGene00004776
• Length: 683
• Species: Caenorhabditis elegans
• Alignment Length: 482
• Identity: 138/482 - (28%)
• Similarity: 232/482 - (48%)
• Gaps: 84/482 - (17%)

Human    36 TESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIG--GNTLVILAVSLEKKLQYATNYFLMSLAV 98
            |.|:.....|::...|........|.|:.::..||  ||.||.:|::.:::|...|||||.|||:
 Worm    35 TTSVWSIRVQLIPTMGIYHFNGVALFLLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLAL 99

Human    99 ADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQA 163
            |||||...|||::::..:...:|...:.:|..:::.||...:|||:|:..||:|||:.|.:|::.
 Worm   100 ADLLVCCIVMPLSIVVEVRHGVWTWSVSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLRT 164

Human   164 NQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFT 228
            .. .|:...||||.:||::::.::.|:.:..:....:...|..|::. .|:  ::::||...|..
 Worm   165 RN-RSKTLIFIKIAIVWVVTLLVSCPIAVLAMHDTANILRNNQCMIF-SRY--YIIYGSTMTFLI 225

Human   229 PLAIMIVTYFLTIHALQKKAYLVKNK--------------PPQRLTW-----LTVSTVFQRDET- 273
            ||.||.|||..|...|.|:|.::..|              |.::|.:     .||:......:.
 Worm   226 PLCIMGVTYAKTTQLLNKQASILSQKAGDKFNGNGLRRTMPHRKLGYARTYSATVNGTIANGKAI 290

Human   274 -----PCSSPEKVAMLDGSRKDK------ALPNSGDETLMR---------RTST--------IGK 310
                 ..||...:|  :|...|:      ::..:|.:.|.:         |||.        :|:
 Worm   291 GAHGRTMSSISNIA--NGETADRLGTSRPSINTNGHKQLQKASTINKWKSRTSNLVTNFANKVGR 353

Human   311 KS-----VQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGY 370
            :|     .|.::||.:|::||.:||..|.:.|.|||..|. |:.....|......:..||:|:||
 Worm   354 RSSLQTATQDLANEHKATRVLAVVFACFFICWTPFFFINF-LIGFGGENVQIPDWVASIFLWLGY 417

Human   371 VSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRN 435
            |||.:||::||:|||.||.||.|.:.|     :....||. |.::|.||             ...
 Worm   418 VSSTINPIIYTVFNKRFRQAFVRILRC-----QCFHPLRD-SHQMYSRN-------------FTT 463

Human   436 GINPAMYQSPMRLRSSTIQSSSIILLD 462
            .|.|..|...   ||:..:::|:|..|
 Worm   464 TIVPDTYTCS---RSNQERTTSVITRD 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2B	NP_000858.3	7tmA_5-HT2B	55..398	CDD:341347	119/397 (30%)
		TM helix 1	56..82	CDD:341347	9/27 (33%)
		TM helix 2	89..115	CDD:341347	16/25 (64%)
		TM helix 3	128..158	CDD:341347	12/29 (41%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	152..154		1/1 (100%)
		TM helix 4	170..193	CDD:341347	7/22 (32%)
		[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	212..215		1/2 (50%)
		TM helix 5	214..243	CDD:341347	11/28 (39%)
		TM helix 6	317..347	CDD:341347	13/29 (45%)
		TM helix 7	359..384	CDD:341347	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	376..380		2/3 (67%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294	479..481
ser-1	NP_001024728.1	7tmA_5-HT2	56..438	CDD:320180	116/388 (30%)
		TM helix 1	57..83	CDD:320180	9/25 (36%)
		TM helix 2	90..116	CDD:320180	16/25 (64%)
		TM helix 3	129..159	CDD:320180	12/29 (41%)
		TM helix 4	170..193	CDD:320180	7/22 (32%)
		TM helix 5	211..240	CDD:320180	12/30 (40%)
		TM helix 6	365..395	CDD:320180	13/30 (43%)
		TM helix 7	406..431	CDD:320180	12/24 (50%)