Protein Alignment HTR2B and Htr2b

DIOPT Version :10

• Sequence 1: NP_000858.3
• Gene: HTR2B / 3357
• HGNCID: 5294
• Length: 481
• Species: Homo sapiens
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 497
• Identity: 400/497 - (80%)
• Similarity: 434/497 - (87%)
• Gaps: 18/497 - (3%)

Human     1 MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVI 65
            ||.||::|| |||..|||||.|..|:|.:|.|||:|:|:.|||||.||.||:.:||||||||.||
Mouse     1 MASSYKMSE-QSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVI 64

Human    66 IPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPA 130
            |||||||.||||||:|||:|||||||||||||:|||||||||||||||||||||:|||||.||||
Mouse    65 IPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPA 129

Human   131 WLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISI----------- 184
            ||||||||||||||||||||:||||||||||||||.||||||||||||||||||
Mouse   130 WLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGMWGMPLFPYG 194

Human   185 -----GIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHAL 244
                 |||||||||||||||.||:|:||.|||:|||.||:||||||||.||.||:||||||||.|
Mouse   195 QNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTL 259

Human   245 QKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIG 309
            ||||||||||||||||..||.|||.|:::..||||||||||||.:||.||||.|||||||.|::|
Mouse   260 QKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVG 324

Human   310 KKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSG 374
            |:|.|||||||||||.||:||||||||||||||||:||.||||||||||:.||||||||||||||
Mouse   325 KRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSG 389

Human   375 VNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINP 439
            ||||:|||||||||:|||||||||||||||||.|||.||.:.|.|.|.||||||.||||||||||
Mouse   390 VNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINP 454

Human   440 AMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV 481
            |||||||||||||||||||||||| |||||:|||.||||||:
Mouse   455 AMYQSPMRLRSSTIQSSSIILLDT-LLTENDGDKAEEQVSYI 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2B	NP_000858.3	7tmA_5-HT2B	55..398	CDD:341347	296/358 (83%)
		TM helix 1	56..82	CDD:341347	22/25 (88%)
		TM helix 2	89..115	CDD:341347	24/25 (96%)
		TM helix 3	128..158	CDD:341347	28/29 (97%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	152..154		1/1 (100%)
		TM helix 4	170..193	CDD:341347	22/38 (58%)
		[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	212..215		1/2 (50%)
		TM helix 5	214..243	CDD:341347	23/28 (82%)
		TM helix 6	317..347	CDD:341347	26/29 (90%)
		TM helix 7	359..384	CDD:341347	21/24 (88%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000305|PubMed:23519215, ECO:0000305|PubMed:28129538	376..380		3/3 (100%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294	479..481		1/1 (100%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	296/358 (83%)
		TM helix 1	56..80	CDD:410628	21/23 (91%)
		TM helix 2	89..111	CDD:410628	20/21 (95%)
		TM helix 3	128..150	CDD:410628	21/21 (100%)
		TM helix 4	173..205	CDD:410628	15/31 (48%)
		TM helix 5	230..253	CDD:410628	17/22 (77%)
		TM helix 6	338..360	CDD:410628	19/21 (90%)
		TM helix 7	374..399	CDD:410628	21/24 (88%)