DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HTR2B and htr2b

DIOPT Version :9

Sequence 1:	NP_000858.3	Gene:	HTR2B / 3357	HGNCID:	5294	Length:	481	Species:	Homo sapiens
Sequence 2:	XP_004914439.1	Gene:	htr2b / 101731179	XenbaseID:	XB-GENE-989949	Length:	478	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	304/451 - (67%)
Similarity:	359/451 - (79%)	Gaps:	24/451 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    38 SIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLL 102
            ::||:.            |.|||.:|||:||||||.|||||:|||||||.|||||||||||||||
Frog    45 AVPEKC------------WLALLTIMVIVPTIGGNILVILAISLEKKLQNATNYFLMSLAVADLL 97

Human   103 VGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYN 167
            ||:|||||||:.|:|:.:|.||..||..||||||||||||||||||||:||||||||||||:|||
Frog    98 VGIFVMPIALINILFQQVWQLPQCLCAIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYN 162

Human   168 SRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPN-----NITCVLTKERFGDFMLFGSLAAFF 227
            ||....|||.|||:||.|||:|:||:|:.    .||     :.|||:..|.|..|:::||:||||
Frog   163 SRGKTLIKIAVVWVISAGIAVPIPIQGLL----YPNTTFSASYTCVVGLEPFKYFIIYGSMAAFF 223

Human   228 TPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKA 292
            .|..||:|.||||||.|:|||||:||||||||||.|||||||||.||.|||||:.||:|.|||..
Frog   224 VPFGIMVVIYFLTIHLLRKKAYLIKNKPPQRLTWSTVSTVFQRDMTPGSSPEKIVMLEGPRKDGT 288

Human   293 LPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC--DSCNQ 355
            ...:|:|..:||.|::||||:|||:||||||||||||||||:.|||||||||:|.|||  |.|::
Frog   289 FNFTGEELPIRRLSSVGKKSMQTITNEQRASKVLGIVFFLFVFMWCPFFITNVTSVLCGKDQCDE 353

Human   356 TTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP 420
            ..::||::||||:||:||||||||||||||||||||.|||.||:...:|||.||..||:|.|||.
Frog   354 DVIKMLMDIFVWVGYISSGVNPLVYTLFNKTFRDAFRRYIKCNFHGMQSVKLLRNCSSRISFRNS 418

Human   421 MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV 481
            ||||||...|||:||||||.|||||:||.:..::||: ||||||||||||..|||||||||
Frog   419 MAENSKLIMKHGMRNGINPVMYQSPLRLCNGQLESSA-ILLDTLLLTENEAGKTEEQVSYV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HTR2B	NP_000858.3	7tm_1	71..380	CDD:278431	217/315 (69%)
		7tm_4	72..>188	CDD:304433	91/115 (79%)
		Agonist binding. /evidence=ECO:0000269\|PubMed:23519215, ECO:0000269\|PubMed:24357322, ECO:0000269\|PubMed:28129538, ECO:0007744\|PDB:4IB4, ECO:0007744\|PDB:4NC3, ECO:0007744\|PDB:5TVN	135..140		4/4 (100%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000305\|PubMed:23519215, ECO:0000305\|PubMed:28129538	152..154		1/1 (100%)
		[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000305\|PubMed:23519215, ECO:0000305\|PubMed:28129538	212..215		1/2 (50%)
		Agonist binding. /evidence=ECO:0000269\|PubMed:23519215, ECO:0000269\|PubMed:24357322, ECO:0000269\|PubMed:28129538, ECO:0007744\|PDB:4IB4, ECO:0007744\|PDB:4NC3, ECO:0007744\|PDB:5TVN	337..341		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000305\|PubMed:23519215, ECO:0000305\|PubMed:28129538	376..380		3/3 (100%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11150294	479..481		1/1 (100%)
htr2b	XP_004914439.1	7tm_GPCRs	50..396	CDD:391938	244/361 (68%)
		TM helix 1	52..76	CDD:341315	17/23 (74%)
		TM helix 2	85..107	CDD:341315	20/21 (95%)
		TM helix 3	124..146	CDD:341315	19/21 (90%)
		TM helix 4	169..185	CDD:341315	11/15 (73%)
		TM helix 5	211..234	CDD:341315	11/22 (50%)
		TM helix 6	316..341	CDD:341315	22/24 (92%)
		TM helix 7	357..382	CDD:341315	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I4936
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55492
Inparanoid	1	1.050	600	1.000	Inparanoid score	I6464
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001488
OrthoInspector	1	1.000	-	-		oto158090
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050