Protein Alignment CG31776 and GALNT3

DIOPT Version :10

• Sequence 1: NP_722909.2
• Gene: CG31776 / 33568
• FlyBaseID: FBgn0051776
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_004473.2
• Gene: GALNT3 / 2591
• HGNCID: 4125
• Length: 633
• Species: Homo sapiens
• Alignment Length: 702
• Identity: 210/702 - (29%)
• Similarity: 319/702 - (45%)
• Gaps: 159/702 - (22%)

  Fly     5 LRLIVRL------------LLAILLTSLVTTILMGKQI-----------------HRRLVKSMVK 40
            |:.:|:|            |.|::...::..:||.:::                 ..:::..|::
Human     4 LKRLVKLHIKRHYHKKFWKLGAVIFFFIIVLVLMQREVSVQYSKEESRMERNMKNKNKMLDLMLE 68

  Fly    41 TTGE-KDSLPARQL--PKR------------------EISPKVADFPPPLTLNQTELDILKIQRN 84
            .... ||::|..|:  |.|                  |:.| |.|.||
Human    69 AVNNIKDAMPKMQIGAPVRQNIDAGERPCLQGYYTAAELKP-VLDRPP----------------- 115

  Fly    85 NSFRLPQQEAIKEWQDAIFFKEDSNRRGLGEQGRAVQLPNAKLNPDDFQD-------FYAELSDR 142
                                 :|||  ..|..|:|.:..|..:.....::       |.|..|||
Human   116 ---------------------QDSN--APGASGKAFKTTNLSVEEQKEKERGEAKHCFNAFASDR 157

  Fly   143 IPLNRSL-PDTRPISCRKRKY--LENLPNVTVIIAFHDEHLSVLLRSITSIINRSPVELLKQIVL 204
            |.|:|.| |||||..|.::|:  ...||..:|||.||:|..|.|||::.|::..||..|||:|:|
Human   158 ISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIIL 222

  Fly   205 VDDDSNLPELGQQLEEIVAQNFPKIIHILRLPERRGSIKARMEAIRVSSCQVLVFLDSHIEVNTN 269
            |||.|....|..:|:|.|.|.  .|:.|:|..||:|.|.||:....|::.:.|.|||:|.|....
Human   223 VDDASVDEYLHDKLDEYVKQF--SIVKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYG 285

  Fly   270 WLPPLLEPIVINPHIVTRPILDAISRKTFAYAKQ----NTMTRSGFNWWLES--ESLPIFPEDKS 328
            ||.|||..|..|...|..|.:.:|...||.:.|.    :...|..|:|.|..  ||||...:.:.
Human   286 WLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRR 350

  Fly   329 PDST-PYRTPVLSGAM-AIDRNYFLNLGGFDEQLDTWEAEKFEISFKVWMCGGMMLYVPCARVGH 391
            .|.| |.:||..:|.: :|.:.||..:|.:||:::.|..|..|:||:||.|||.:..:||:.|||
Human   351 KDETYPIKTPTFAGGLFSISKEYFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGH 415

  Fly   392 IGKRPMKSISSPGYHNF------LARNYKRVAEVWMDNYKKYVYDKN---PKLYKMANAGLLFQR 447
            :.:.     .||  |:|      :|||..|:||||||.||:..|.:|   .|:.|....|.|.:|
Human   416 VFRS-----KSP--HSFPKGTQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKAFGDLSKR 473

  Fly   448 KTKRNALECKTFDWYMTKVAPDFLKRYLALDSPLVFSGVIESVAFPGFCVD-SLNCRHTKPVVLA 511
            ...::.|:||.|.||:..:.|:.   |:...:| |.||.|:||..| .|:| ..|.:..||:::.
Human   474 FEIKHRLQCKNFTWYLNNIYPEV---YVPDLNP-VISGYIKSVGQP-LCLDVGENNQGGKPLIMY 533

  Fly   512 RCTGHNSMPGEHQNWSLTQDHEIQLTNSKDDCLE-AQGLRSKSVWLFRCHKN--GGNQYWYYNHR 573
            .|.|    .|.:|.:..:..|||:....|:.||. ||||.......::.||.  .|.|.|.
Human   534 TCHG----LGGNQYFEYSAQHEIRHNIQKELCLHAAQGLVQLKACTYKGHKTVVTGEQIWE---- 590

  Fly   574 HRWIQQGQIWV-----WCLEAQLASGHKVGKVLANKICDKNQLEQQWKVGRN 620
               ||:.|:..     .||.|.       |:..:...|:.:...|:|.:.:|
Human   591 ---IQKDQLLYNPFLKMCLSAN-------GEHPSLVSCNPSDPLQKWILSQN 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31776	NP_722909.2	pp-GalNAc-T	170..467	CDD:133004	120/313 (38%)
		beta-trefoil_Ricin_Pgant8-like	482..618	CDD:467339	41/144 (28%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		50/110 (45%)
		pp-GalNAc-T	188..493	CDD:133004	120/313 (38%)
		Catalytic subdomain B	356..418		25/61 (41%)
		beta-trefoil_Ricin_GALNT3	502..630	CDD:467346	42/147 (29%)