Protein Alignment CG31776 and GALNT1

DIOPT Version :10

• Sequence 1: NP_722909.2
• Gene: CG31776 / 33568
• FlyBaseID: FBgn0051776
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_065207.2
• Gene: GALNT1 / 2589
• HGNCID: 4123
• Length: 559
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 184/557 - (33%)
• Similarity: 278/557 - (49%)
• Gaps: 77/557 - (13%)

  Fly   102 IFFKE-----DSNRRGL----------------GEQGRAVQLPNA---------KLNPDDFQDFY 136
            ::|.|     :...|||                ||.|:.|.:|..         |:|     .|.
Human    26 LYFSECNKCDEKKERGLPAGDVLEPVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKIN-----QFN 85

  Fly   137 AELSDRIPLNRSLPDTRPISCRKRKYLENLPNVTVIIAFHDEHLSVLLRSITSIINRSPVELLKQ 201
            ...|:.|.|||||||.|...|:.:.|.:|||..:|:|.||:|..|.|||::.|:|||||..::::
Human    86 LMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEE 150

  Fly   202 IVLVDDDSNLPELGQQLEEIVAQ-NFPKIIHILRLPERRGSIKARMEAIRVSSCQVLVFLDSHIE 265
            ||||||.|....|.:.||..|.: ..|  :|::|:.:|.|.|:||::...||..||:.|||:|.|
Human   151 IVLVDDASERDFLKRPLESYVKKLKVP--VHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCE 213

  Fly   266 VNTNWLPPLLEPIVINPHIVTRPILDAISRKTFAYAKQNTMTRSGFNWWLESESLPI----FPED 326
            ....||.|||..|..:...|..||:|.||..||.|...:.||..||||.|.....|:    ....
Human   214 CTVGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRR 278

  Fly   327 KSPDSTPYRTPVLSGAM-AIDRNYFLNLGGFDEQLDTWEAEKFEISFKVWMCGGMMLYVPCARVG 390
            |...:.|.|||.::|.: :|||:||..:|.:|..:|.|..|..||||::|.|||.:..|.|:.||
Human   279 KGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVG 343

  Fly   391 HIGKRPMKSISSPGYHNFLARNYKRVAEVWMDNYKKYVYDKNPKLYKMANAGLLFQRKTKRNALE 455
            |:.::........|....:.:|.:|:||||||.:|.:.|..:|.:.|: :.|.:..|...|:.|:
Human   344 HVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKV-DYGDISSRVGLRHKLQ 407

  Fly   456 CKTFDWYMTKVAPD--FLKRYLALDSPLVFSGVIESVAFPGFCVDSLNCRHTKPVVLARCTGHNS 518
            ||.|.||:..:.||  ..:.|.:|       |.|.:|. ...|:|::..:..:.|.:..|.|
Human   408 CKPFSWYLENIYPDSQIPRHYFSL-------GEIRNVE-TNQCLDNMARKENEKVGIFNCHG--- 461

  Fly   519 MPGEHQNWSLTQDHEIQLTNSKDDCLEAQGLRSKSVWLFRCHKNGGNQYWYYNH-----RHRWIQ 578
             .|.:|.:|.|.:.||:   :.|.||:...|.. .|.:.:||...|||.|.|:.     :|  :.
Human   462 -MGGNQVFSYTANKEIR---TDDLCLDVSKLNG-PVTMLKCHHLKGNQLWEYDPVKLTLQH--VN 519

  Fly   579 QGQIWVWCLEAQLASGHKVGKVLANKICDKNQLEQQW 615
            ..|    ||:.......:|..:   :.|:.:: .|||
Human   520 SNQ----CLDKATEEDSQVPSI---RDCNGSR-SQQW 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31776	NP_722909.2	pp-GalNAc-T	170..467	CDD:133004	117/302 (39%)
		beta-trefoil_Ricin_Pgant8-like	482..618	CDD:467339	35/139 (25%)
GALNT1	NP_065207.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..65		3/19 (16%)
		Catalytic subdomain A	115..225		50/111 (45%)
		pp-GalNAc-T	119..419	CDD:133004	117/302 (39%)
		Catalytic subdomain B	285..347		28/61 (46%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	37/149 (25%)