Protein Alignment CG31776 and GALNT6

DIOPT Version :10

• Sequence 1: NP_722909.2
• Gene: CG31776 / 33568
• FlyBaseID: FBgn0051776
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_009141.2
• Gene: GALNT6 / 11226
• HGNCID: 4128
• Length: 622
• Species: Homo sapiens
• Alignment Length: 668
• Identity: 199/668 - (29%)
• Similarity: 304/668 - (45%)
• Gaps: 149/668 - (22%)

  Fly     5 LRLIVR----LLLAILLTSLVTTILMGKQIHRRL-----------VKSMVKTTGE---------- 44
            :||:.|    |.||::..:.|..:.:   :||.:           :||:|.....
Human     1 MRLLRRRHMPLRLAMVGCAFVLFLFL---LHRDVSSREEATEKPWLKSLVSRKDHVLDLMLEAMN 62

  Fly    45 --KDSLPARQLPKREISPKVADFPPPLTLNQTELDILKIQRNNSFRLPQQEAIKE-WQDAIFFKE 106
              :||:|..|:...|....:      .::||:.|.        .|..|.:  :|. |:..   .:
Human    63 NLRDSMPKLQIRAPEAQQTL------FSINQSCLP--------GFYTPAE--LKPFWERP---PQ 108

  Fly   107 DSNRRGLGEQGRAVQLPNAKLNPDDFQD---------FYAELSDRIPLNRSL-PDTRPISCRKRK 161
            |.|  ..|..|:|.|  .:|..|.:.|:         |.|..||||.|.||| |||||..|..:|
Human   109 DPN--APGADGKAFQ--KSKWTPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQK 169

  Fly   162 YLENLPNVT--VIIAFHDEHLSVLLRSITSIINRSPVELLKQIVLVDDDSNLPELGQQLEEIVAQ 224
            :....|..|  |||.||:|..|.|||::.|:::.:|..|||:|:||||.|....|.::||:.|.|
Human   170 FRRCPPLATTSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQ 234

  Fly   225 NFPKIIHILRLPERRGSIKARMEAIRVSSCQVLVFLDSHIEVNTNWLPPLLEPIVINPHIVTRPI 289
              .:::.::|..||:|.|.||:....|:..:||.|||:|.|....||.|||..|..:..:|..|.
Human   235 --LQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPD 297

  Fly   290 LDAISRKTFAYAKQ----NTMTRSGFNW-----WLESESLPIFPEDKSPDST-PYRTPVLSGAM- 343
            :..|...||.:||.    ...:|..|:|     |   |:||...:.:..|.| |.::|..:|.:
Human   298 IVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGW---ETLPPHEKQRRKDETYPIKSPTFAGGLF 359

  Fly   344 AIDRNYFLNLGGFDEQLDTWEAEKFEISFKVWMCGGMMLYVPCARVGHIGKRPMKSISSPGYHNF 408
            :|.::||.::|.:|.|::.|..|..|:||:||.|||.:..:||:.|||:.:     ..||  |.|
Human   360 SISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFR-----TKSP--HTF 417

  Fly   409 ------LARNYKRVAEVWMDNYKKYVYDKNPKLYKMA---NAGLLFQRKTKRNALECKTFDWYMT 464
                  :|||..|:||||||:|||..|.:|.:..|||   :.|.:.:|...|..|.|..|.||:.
Human   418 PKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLH 482

  Fly   465 KVAPDFLKRYLALDSPLVFSGVIESVAFPGFCVD-SLNCRHTKPVVLARC--------------- 513
            .|.|:.    ...|....|.|.|:::. ...|:| ..|.|..||:::..|
Human   483 NVYPEM----FVPDLTPTFYGAIKNLG-TNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQR 542

  Fly   514 --------------------------TGHNSMPGEHQNWSLTQDHEIQLTNSKDDCLEAQGLRSK 552
                                      ||.||...:.:.|.|.||..|:.:.| ..||.:|   .|
Human   543 DLRHNIAKQLCLHVSKGALGLGSCHFTGKNSQVPKDEEWELAQDQLIRNSGS-GTCLTSQ---DK 603

  Fly   553 SVWLFRCHKNGGNQYWYY 570
            ...:..|:.:..:|.|.:
Human   604 KPAMAPCNPSDPHQLWLF 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31776	NP_722909.2	pp-GalNAc-T	170..467	CDD:133004	118/318 (37%)
		beta-trefoil_Ricin_Pgant8-like	482..618	CDD:467339	27/131 (21%)
GALNT6	NP_009141.2	Catalytic subdomain A	176..285		47/110 (43%)
		pp-GalNAc-T	180..485	CDD:133004	117/316 (37%)
		Catalytic subdomain B	348..410		24/61 (39%)
		beta-trefoil_Ricin_GALNT6	495..622	CDD:467348	27/132 (20%)