Protein Alignment Pif1 and RRM3

DIOPT Version :10

• Sequence 1: NP_608782.1
• Gene: Pif1 / 33567
• FlyBaseID: FBgn0031540
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_011896.1
• Gene: RRM3 / 856426
• SGDID: S000001073
• Length: 723
• Species: Saccharomyces cerevisiae
• Alignment Length: 639
• Identity: 199/639 - (31%)
• Similarity: 302/639 - (47%)
• Gaps: 133/639 - (20%)

  Fly   102 TIFVKMNGNEGGSQPDDATLQK-----KLREHLMSGK----PSSFNDVSPVTTA----------- 146
            ::|.:..|:.|...| ||..:|     :|..:..|.:    .||.:..:..:|.
Yeast    87 SLFSQSQGSFGDDDP-DAEFKKLVDVPRLNSYKKSSRSLSMTSSLHKTASASTTQKTYHFDEDET 150

  Fly   147 --EMILARKKAGLLSKGS----------VTTPSPQGAKKRR----FEELKEEKERGTMPAAKKLY 195
              |:...:..:..||..|          ::|.|.:.||:.:    |:.||....:...|..:|..
Yeast   151 LREVTSVKSNSRQLSFTSTINIEDSSMKLSTDSERPAKRSKPSMEFQGLKLTVPKKIKPLLRKTV 215

  Fly   196 ASTTDESLR-------LSEEQMEVLRACTSGK-SVFFTGSAGTGKSFLLRRIISALP----PDGT 248
            ::....:.|       |:.||..|:......: :||:|||||||||.:|:.||..|.    .:..
Yeast   216 SNMDSMNHRSASSPVVLTMEQERVVNLIVKKRTNVFYTGSAGTGKSVILQTIIRQLSSLYGKESI 280

  Fly   249 VATASTGVAACLIGGTTLHAFAGIGGGDATMQRCL-ELASRPANAQTWRKCKRLIIDEISMVDGQ 312
            ..|||||:||..|||:|||.::|||.|:.|:.:.: ::.|:......||..|.|||||||||||.
Yeast   281 AITASTGLAAVTIGGSTLHKWSGIGIGNKTIDQLVKKIQSQKDLLAAWRYTKVLIIDEISMVDGN 345

  Fly   313 FFEKIEAVARHIRRNDRPFGGIQLILCGDFLQLPPVIKGDFGAAPTATPQQRFCFQSSAWETCIQ 377
            ..:|:|.:||.||:||.|||||||:|.|||.|||||.|.|      .....:|||:|..|:.|||
Yeast   346 LLDKLEQIARRIRKNDDPFGGIQLVLTGDFFQLPPVAKKD------EHNVVKFCFESEMWKRCIQ 404

  Fly   378 CVYELKQVHRQSDPEFVKILNHLRIGHVNDSITSRLAATSKQKIEGNGILATQLCSHTNDANSIN 442
            ....|.:|.||.|.:.:.|||.:|.|.:...|...:...::.....:||..|:|.:...:....|
Yeast   405 KTILLTKVFRQQDNKLIDILNAIRYGELTVDIAKTIRNLNRDIDYADGIAPTELYATRREVELSN 469

  Fly   443 ESKLENLDGDKILFKA-DDSDASMTRTLDQQIQAPSQLYLKVNAQVMLLKNINISNGLVNGARG- 505
            ..||::|.||...||| |::.......||..:.....:.||.:||||:||| .....||||:.|
Yeast   470 VKKLQSLPGDLYEFKAVDNAPERYQAILDSSLMVEKVVALKEDAQVMMLKN-KPDVELVNGSLGK 533

  Fly   506 --------VVVRMEK-----------DLPVVR-------FKNNQEY------------------- 525
                    :||:|::           |:.:|.       .|.::|:
Yeast   534 VLFFVTESLVVKMKEIYKIVDDEVVMDMRLVSRVIGNPLLKESKEFRQDLNARPLARLERLKILI 598

  Fly   526 -----VCKHE------RWIIKTASGNH------------------ITRRQVPLKLAWAFSIHKSQ 561
                 :..|:      ||.:......|                  :.|.|:||.|.||.||||:|
Yeast   599 NYAVKISPHKEKFPYVRWTVGKNKYIHELMVPERFPIDIPRENVGLERTQIPLMLCWALSIHKAQ 663

  Fly   562 GLTLDCVEMSLSKVFEAGQAYVALSRAKSLQSIRILDFDAKQVWANPHVLQFYK 615
            |.|:..:::.|.::|||||.|||||||.::.::::|:||..::..|..|..|||
Yeast   664 GQTIQRLKVDLRRIFEAGQVYVALSRAVTMDTLQVLNFDPGKIRTNERVKDFYK 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pif1	NP_608782.1	RecD	<190..591	CDD:440273	167/489 (34%)
		DEXSc_Pif1_like	208..387	CDD:350795	87/184 (47%)
RRM3	NP_011896.1	RecD	<232..696	CDD:440273	165/470 (35%)
		DEXSc_Pif1_like	235..414	CDD:350795	87/184 (47%)