Protein Alignment Pif1 and PIF1

DIOPT Version :9

• Sequence 1: NP_001285587.1
• Gene: Pif1 / 33567
• FlyBaseID: FBgn0031540
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001273426.1
• Gene: PIF1 / 80119
• HGNCID: 26220
• Length: 707
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 295/651 - (45%)
• Similarity: 392/651 - (60%)
• Gaps: 39/651 - (5%)

  Fly     2 DLNDAVLTCAVNMEWTNAVGITGRKLAYKTATLRLVRNDLRELFVEV-TPEKL-KPLKFKLKDLM 64
            :..|:.|.|.|.:|..:..|...|:.|.:||.|.|.||:.|||.:.: .|... :|..|.|:...
Human    11 EYEDSELRCRVAVEELSPGGQPRRRQALRTAELSLGRNERRELMLRLQAPGPAGRPRCFPLRAAR 75

  Fly    65 VHKKFMSEGKATFNFKAE------KCTLYLSNAPPGTLMFFLRTIFVKMNGNEGGSQPDDATLQK 123
            :..:|...|::|....|.      ...|.||:.||..|..||||:.:|:....|   |..|:
Human    76 LFTRFAEAGRSTLRLPAHDTPGAGAVQLLLSDCPPDRLRRFLRTLRLKLAAAPG---PGPAS--- 134

  Fly   124 KLREHLMSGKPSSFNDVSPVTTAEMILARKKAGLLSKGSVTTP-SPQ-GAKKRRFEELKEEKERG 186
             .|..|:..:|..|..:|||...|..| |....:.....|..| .|| ||      |...|..|.
Human   135 -ARAQLLGPRPRDFVTISPVQPEERRL-RAATRVPDTTLVKRPVEPQAGA------EPSTEAPRW 191

  Fly   187 TMPAAKKLYASTTDESLRLSEEQMEVLRACTSGKSVFFTGSAGTGKSFLLRRIISALPPDGTVAT 251
            .:|..:....||..:   |||||..||||...|:|:|||||||||||:||:||:.:|||.|||||
Human   192 PLPVKRLSLPSTKPQ---LSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVAT 253

  Fly   252 ASTGVAACLIGGTTLHAFAGIGGGDATMQRCLELASRPANAQTWRKCKRLIIDEISMVDGQFFEK 316
            ||||||||.|||||||||||||.|.|.:.:|:.||.||...|.|..|:||:|||||||:...|:|
Human   254 ASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQRLVIDEISMVEADLFDK 318

  Fly   317 IEAVARHIRRNDRPFGGIQLILCGDFLQLPPVIKGDFGAAPTATPQQRFCFQSSAWETCIQCVYE 381
            :|||||.:|:.::||||||||:||||||||||.||        :...||||||.:|:.|:....|
Human   319 LEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTKG--------SQPPRFCFQSKSWKRCVPVTLE 375

  Fly   382 LKQVHRQSDPEFVKILNHLRIGHVNDSITSRLAATSKQKIEGNGILATQLCSHTNDANSINESKL 446
            |.:|.||:|..|:.:|..:|:|..:|.:|.:|.||:..|:..:||:||:||:|.:|....||.:|
Human   376 LTKVWRQADQTFISLLQAVRLGRCSDEVTRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRL 440

  Fly   447 ENLDGDKILFKADDSDASMTRTLDQQIQAPSQLYLKVNAQVMLLKNINISNGLVNGARGVVVRME 511
            :.|.|....|:|.||:..:..|||.|......|.||:.|||||:||:::|.|||||||||||..|
Human   441 QELPGKVHRFEAMDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVVGFE 505

  Fly   512 ---KDLPVVRFKNNQEYVCKHERWIIKTASGNHITRRQVPLKLAWAFSIHKSQGLTLDCVEMSLS 573
               :.||.|||......|...:||.::...|..::|:|:||:||||.|||||||:||||||:||.
Human   506 AEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAMSIHKSQGMTLDCVEISLG 570

  Fly   574 KVFEAGQAYVALSRAKSLQSIRILDFDAKQVWANPHVLQFYKGFRRKLMDTTMIPLGPKNKDKKP 638
            :||.:||||||||||:|||.:|:||||...|..:|.||.||...||. ...::...|..|:|:..
Human   571 RVFASGQAYVALSRARSLQGLRVLDFDPMAVRCDPRVLHFYATLRRG-RSLSLAAEGRGNEDRCS 634

  Fly   639 G 639
            |
Human   635 G 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pif1	NP_001285587.1	P-loop_NTPase	205..510	CDD:304359	169/304 (56%)
PIF1	NP_001273426.1	PINT	1..180		52/176 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..192		8/24 (33%)
		PIF1	206..504	CDD:253483	169/308 (55%)
		Herpes_Helicase	<551..611	CDD:280797	40/59 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158836
Domainoid	1	1.000	252	1.000	Domainoid score	I2102
eggNOG	1	0.900	-	-		E1_COG0507
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H99775
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55717
OrthoDB	1	1.010	-	-		D413010at33208
OrthoFinder	1	1.000	-	-		FOG0002406
OrthoInspector	1	1.000	-	-		oto90132
orthoMCL	1	0.900	-	-		OOG6_100049
Panther	1	1.100	-	-	LDO	PTHR23274
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R921
SonicParanoid	1	1.000	-	-		X3535
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800