DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pif1 and pif1

DIOPT Version :9

Sequence 1:	NP_001285587.1	Gene:	Pif1 / 33567	FlyBaseID:	FBgn0031540	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_004914012.2	Gene:	pif1 / 549357	XenbaseID:	XB-GENE-5924613	Length:	704	Species:	Xenopus tropicalis

Alignment Length:	635	Identity:	295/635 - (46%)
Similarity:	408/635 - (64%)	Gaps:	55/635 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AVNMEWTNAVGITGRKLAYKTATLRLVRNDLRELFVEVTPEKLKPLKFKLKDLMVHKKFMSEGKA 75
            ::.:|:.|:.|.|.::.|.:.|.:.|.||:.|:|.::|:..||:. .|.||.:.:..:|:.:|||
Frog    82 SITIEYLNSSGQTLKRKAIRNALVSLGRNEFRDLVLKVSDGKLQQ-NFVLKQIKLFTRFIRDGKA 145

  Fly    76 TFNFKAEKCTLYLSNAPPGTLMFFLRTIFVKMNGNEGGSQPDDATLQKKLRE--HLMSGKPSSFN 138
            :.....|...|.:||.|...|..|::|:.:|   :|.|.      .:|.:.|  .|:||.|..|.
Frog   146 SVVLLPENVQLLISNCPSDKLQHFMKTLLIK---HEAGK------TEKPVNERTRLLSGLPRVFE 201

  Fly   139 DVSPVTTAEMILA---RKKA---------GLLSKGSVTTPSPQGAKKRRFE-------ELKEEKE 184
            .:|||...::..|   |.||         ||.:|| |...:....|:.|.|       :|:..|:
Frog   202 TISPVQKKDVEQANEMRAKANSETPVKGRGLSNKG-VNGVNRCQQKRTRTESSNSLIADLRPSKK 265

  Fly   185 RG-TMPAAKKLYASTTDESLRLSEEQMEVLRACTSGKSVFFTGSAGTGKSFLLRRIISALPPDGT 248
            .. :||           :.:|||.||..||....||::||||||||||||:||:||:.||||..|
Frog   266 PTLSMP-----------KQVRLSTEQSLVLNTVLSGRNVFFTGSAGTGKSYLLKRIVGALPPKST 319

  Fly   249 VATASTGVAACLIGGTTLHAFAGIGGGDATMQRCLELASRPANAQTWRKCKRLIIDEISMVDGQF 313
            .||||||||||.|||||||||||||.|.|::::|:|||.||...|.|..||.|||||||||:|:|
Frog   320 YATASTGVAACHIGGTTLHAFAGIGTGKASIEQCIELAKRPGVRQHWTGCKHLIIDEISMVEGEF 384

  Fly   314 FEKIEAVARHIRRNDRPFGGIQLILCGDFLQLPPVIKGDFGAAPTATPQQRFCFQSSAWETCIQC 378
            |:|:|||||.:|..|.||||||||:||||||||||.:        |:.|.:||||:.:|..||..
Frog   385 FDKLEAVARAVRGKDEPFGGIQLIVCGDFLQLPPVTQ--------ASSQTKFCFQARSWRKCIHL 441

  Fly   379 VYELKQVHRQSDPEFVKILNHLRIGHVNDSITSRLAATSKQKIEGNGILATQLCSHTNDANSINE 443
            ..||.:|.||:|..|:.:|..:|:|...|.::.:|..||..|:|.:|||||:||:|.:|....||
Frog   442 TMELTEVRRQTDKNFISLLQAIRLGRCTDDVSRKLLQTSSHKVERDGILATRLCTHKDDVEITNE 506

  Fly   444 SKLENLDGDKILFKADDSDASMTRTLDQQIQAPSQLYLKVNAQVMLLKNINISNGLVNGARGVVV 508
            .:|:.|.|:..|::|.|||..:.:|::.|.....|:.||..|||||.||:::|.||||||||||.
Frog   507 RRLQQLPGESHLYEALDSDPMLVKTINAQCPVNQQIQLKKGAQVMLAKNLDVSRGLVNGARGVVT 571

  Fly   509 RME---KDLPVVRFKNNQEYVCKHERWIIKTASGNHITRRQVPLKLAWAFSIHKSQGLTLDCVEM 570
            :.|   |:||||||......|.|.:||:.|...|.:::|:|:|||||||.|||||||::|||||:
Frog   572 KFEEGNKNLPVVRFLCGVTEVIKPDRWVFKGHGGIYLSRQQLPLKLAWAISIHKSQGMSLDCVEI 636

  Fly   571 SLSKVFEAGQAYVALSRAKSLQSIRILDFDAKQVWANPHVLQFYKGFRRK 620
            |||:|||:||||||||||::|:.:|::|||.|.|.|||:|||||...|::
Frog   637 SLSRVFESGQAYVALSRARNLEGLRVMDFDPKVVRANPYVLQFYSQMRKE 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pif1	NP_001285587.1	P-loop_NTPase	205..510	CDD:304359	169/304 (56%)
pif1	XP_004914012.2	DEXSc_Pif1_like	279..450	CDD:350795	112/178 (63%)
pif1	XP_004914012.2	RecD	<284..700	CDD:223581	231/411 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2074
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H99775
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1212
OMA	1	1.010	-	-		QHG55717
OrthoDB	1	1.010	-	-		D413010at33208
OrthoFinder	1	1.000	-	-		FOG0002406
OrthoInspector	1	1.000	-	-		oto103933
Panther	1	1.100	-	-	LDO	PTHR23274
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3535
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080