Protein Alignment msl-2 and Msl2

DIOPT Version :10

• Sequence 1: NP_523467.1
• Gene: msl-2 / 33565
• FlyBaseID: FBgn0005616
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: NP_001093921.1
• Gene: Msl2 / 77853
• MGIID: 1925103
• Length: 577
• Species: Mus musculus
• Alignment Length: 637
• Identity: 142/637 - (22%)
• Similarity: 235/637 - (36%)
• Gaps: 170/637 - (26%)

  Fly     2 AQTAYLKVTRIAMRSASNLSKRRVEELNSGLGELRQLLSCVVCCQLLVDPYSPKGKRCQHNVCRL 66
            |...|:..:|:.:..... ..:...|:|..|...||.|||.||..||.||.:|....|||.||:.
Mouse     6 ATALYISASRLVLNYDPG-DPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNSTCQHYVCKT 69

  Fly    67 CLRGKKHLF-PSCTQCEGCSDFKTYEENRMMAAQLLCYKTLCVHLLHSALFGELAGMRPQVAREL 130
            | :|||.:. |||:.|:   |::.:|||:.::..:.|||.||.::..:.|           ||::
Mouse    70 C-KGKKMMMKPSCSWCK---DYEQFEENKQLSILVNCYKKLCEYITQTTL-----------ARDI 119

  Fly   131 VPRIKLPPKTTQEFIREGSNISDTFDIFLPQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHL 195
            :..:.. .......:.:||       :|..:          |..|:::..|..:|...||
Mouse   120 IEAVDC-SSDILALLNDGS-------LFCEE----------TEKPSDSSFTLCLTHSPLP----- 161

  Fly   196 NISDIEAEAAATAEQGHFSPLPLLPTGSRMGMLSHAGQIVIATESSESGFMDQAWTDQVDLSGTV 260
                      :|:|          ||......||         ..|||       |..:.:..:|
Mouse   162 ----------STSE----------PTADPQASLS---------PMSES-------TLSIAIGSSV 190

  Fly   261 SVSKYTNSG---NNFAVSYVMPTSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLT 322
            .....|.:|   :.|.::...|.      .|..:.:...|.:             :|.:.|..|.
Mouse   191 INGLPTYNGLSIDRFGINIPSPE------HPNTIDVCNTVDI-------------KTEDLSDNLP 236

  Fly   323 VLSTTVEETVETSTQLEVLTSAEEPNEISDQLANLQVEESDEAL--VEETVEEAEGTSIPSEVVA 385
            .:..|| .|...||.:::.:.:|:            ::..|..|  |||.:...|..| .:||..
Mouse   237 PVCDTV-ATDLCSTGIDICSFSED------------IKPGDSLLLSVEEVLRSLETVS-NTEVCC 287

  Fly   386 EHMEEDQHLDVHTSQSPTQTEMEEAVEEHVATKTQLGHVQTELQDAESLQKDFEDAKAAAEEAKE 450
            .:::  .:|:...|..|......:::..:|...|...........|..........::.:|...|
Mouse   288 PNLQ--PNLEATVSNGPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKVAKLNRKRSRSESDSE 350

  Fly   451 KEKDLHAISAELQKEDSDEPTLKRKRTRTLKASQAAKIEPV---------PSEVKTKVQSGKGAL 506
            |.:.| .||..::     .|||......|:|......::|:         |...||.:.|.|...
Mouse   351 KVQPL-PISTIIR-----GPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMK 409

  Fly   507 RR---------------IRGKDKEEKVKPP---------------KPK----CRCGISGSSNTLT 537
            :.               |..|||..|.|.|               ||:    |:||.:..:.::.
Mouse   410 KSHEHGSKKSHSKSKPGILKKDKAVKEKMPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVL 474

  Fly   538 TCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPE 589
            |||..|||||.:..:|..|.|..|:|    .|:.:.| ..||.|.:|:...|
Mouse   475 TCRGQRCPCYSNRKACLDCICRGCQN----SYMANGE-KKLEAFAVPEKALE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msl-2	NP_523467.1	zf-RING_10	39..111	CDD:435513	32/72 (44%)
		PTZ00341	<311..415	CDD:173534	21/105 (20%)
		MSL2-CXC	519..570	CDD:435512	20/69 (29%)
Msl2	NP_001093921.1	Sufficient for interaction with MSL1. /evidence=ECO:0000250|UniProtKB:Q9HCI7	1..116		41/125 (33%)
		zf-RING_10	42..111	CDD:435513	32/72 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..428		1/22 (5%)
		MSL2-CXC	455..509	CDD:435512	20/58 (34%)