Protein Alignment msl-2 and msl2a

DIOPT Version :10

• Sequence 1: NP_523467.1
• Gene: msl-2 / 33565
• FlyBaseID: FBgn0005616
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: NP_001156770.1
• Gene: msl2a / 564400
• ZFINID: ZDB-GENE-070912-449
• Length: 538
• Species: Danio rerio
• Alignment Length: 576
• Identity: 139/576 - (24%)
• Similarity: 219/576 - (38%)
• Gaps: 156/576 - (27%)

  Fly    36 RQLLSCVVCCQLLVDPYSPKGKRCQHNVCRLCLRGKKHLFPSCTQCEGCSDFKTYEENRMMAAQL 100
            |..|||:||..||.||.:||...|||.||:.|...|..|.|||:.|:   |::.:||||.:...:
Zfish    39 RDSLSCLVCGNLLQDPLAPKNSSCQHYVCKGCKGKKMSLKPSCSWCK---DYEQFEENRQLQILI 100

  Fly   101 LCYKTLC------VHLLHSALFGELAGMRPQVARELVPRIKLPPKTTQEFIREGSNISDTFDIFL 159
            .||:.||      |....|.|  |:.|. |:|.:.|                     .:...:.|
Zfish   101 DCYRNLCECVSVWVTTEQSVL--EVKGY-PEVKKML---------------------EEVLGVDL 141

  Fly   160 PQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHLNISDIEAEAAATAEQGHFSPLPL-----L 219
            .|.:|..:||.......:|.|.|:..:.:      :|::|.:..:..|:.... ||.|:     |
Zfish   142 EQEELSPVKDTLEDPQLKTDPESSQNSAD------VNLTDSDKPSDQTSSDPE-SPKPICADEPL 199

  Fly   220 PTGSRMGMLSHAGQIV---IATESS-ESGFMDQAWTDQV-DLSGTVSVSKYTNSGNNFAVSYVMP 279
            .:.|.:.|.|.:..||   |:.|:| ||..:.:..||.: ||...::         |..|||
Zfish   200 SSSSELHMSSVSADIVKCSISPENSPESVHLSEESTDVLEDLKFDIA---------NKEVSY--- 252

  Fly   280 TSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLTVLSTTVEETVETSTQLEVLTSA 344
                    .|.....::.|.:..:|.:...|.....:..|.||.|:     ......:|....|.
Zfish   253 --------EQSKSTAELCQHSLQSQTSGAFAPGHPPQPQTGLTCLA-----AAHRKVRLSRKRSR 304

  Fly   345 EEPNEISDQLANLQVEESDEALVEETVEEAEGTSIPSEVVAEHMEEDQHLDVHTSQSPTQTEMEE 409
            .|.:  |:.|..|.:    .:|:       :|.|:                  .:.:|.:|..|.
Zfish   305 SESD--SEMLQPLPI----TSLI-------QGPSV------------------AATAPPKTAFEP 338

  Fly   410 AVEEHVATKTQLGHV----QTELQDAESLQ--KDFEDAKAAAEEAKEKEKDLHAISAELQKEDSD 468
            ............|.:    :|.|...:::|  .|..:.|.   :||.|      :|....|..|.
Zfish   339 KAPSPPPVMVTNGGILKVNKTVLDSTKNIQINSDMINKKV---QAKSK------VSVPKAKNKSK 394

  Fly   469 EPTLKRKRTRTLKASQAAKIEPVPSEVKTKVQSGKGALRRIRGKDKEEKVKPPKPKCRCGISGSS 533
            |..|    :.:|...|..|:      |..|.|..||                    |:||.:..:
Zfish   395 ERVL----SPSLLPGQPPKV------VYKKTQEKKG--------------------CKCGRATQN 429

  Fly   534 NTLTTCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPE 589
            .::.|||..|||||.:..:|..|.|..|:|    .|:.:.| ..||.|.:|:...|
Zfish   430 PSVLTCRGQRCPCYSNRKACLDCICRGCQN----SYMANGE-KKLEAFAVPEKALE 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msl-2	NP_523467.1	zf-RING_10	39..111	CDD:435513	33/77 (43%)
		PTZ00341	<311..415	CDD:173534	16/103 (16%)
		MSL2-CXC	519..570	CDD:435512	16/50 (32%)
msl2a	NP_001156770.1	zf-RING_10	42..110	CDD:435513	32/70 (46%)
		MSL2-CXC	414..468	CDD:435512	22/78 (28%)