DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msl-2 and MSL2

DIOPT Version :9

Sequence 1:	NP_523467.1	Gene:	msl-2 / 33565	FlyBaseID:	FBgn0005616	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_060603.2	Gene:	MSL2 / 55167	HGNCID:	25544	Length:	577	Species:	Homo sapiens

Alignment Length:	637	Identity:	139/637 - (21%)
Similarity:	234/637 - (36%)	Gaps:	170/637 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AQTAYLKVTRIAMRSASNLSKRRVEELNSGLGELRQLLSCVVCCQLLVDPYSPKGKRCQHNVCRL 66
            |...|:..:|:.:..... ..:...|:|..|...||.|||.||..||.||.:|....|||.||:.
Human     6 ATALYISASRLVLNYDPG-DPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNSTCQHYVCKT 69

  Fly    67 CLRGKKHLF-PSCTQCEGCSDFKTYEENRMMAAQLLCYKTLCVHLLHSALFGELAGMRPQVAREL 130
            | :|||.:. |||:.|:   |::.:|||:.::..:.|||.||.::..:.|           ||::
Human    70 C-KGKKMMMKPSCSWCK---DYEQFEENKQLSILVNCYKKLCEYITQTTL-----------ARDI 119

  Fly   131 VPRIKLPPKTTQEFIREGSNISDTFDIFLPQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHL 195
            :..:.. .......:.:||       :|..:          |..|:::..|..:|...||
Human   120 IEAVDC-SSDILALLNDGS-------LFCEE----------TEKPSDSSFTLCLTHSPLP----- 161

  Fly   196 NISDIEAEAAATAEQGHFSPLPLLPTGSRMGMLSHAGQIVIATESSESGFMDQAWTDQVDLSGTV 260
                 ......|..|...||:                        |||       |..:.:..:|
Human   162 -----STSEPTTDPQASLSPM------------------------SES-------TLSIAIGSSV 190

  Fly   261 SVSKYTNSG---NNFAVSYVMPTSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLT 322
            .....|.:|   :.|.::...|..:.|            :.:.::..:       :|.:.|..|.
Human   191 INGLPTYNGLSIDRFGINIPSPEHSNT------------IDVCNTVDI-------KTEDLSDSLP 236

  Fly   323 VLSTTVEETVETSTQLEVLTSAEEPNEISDQLANLQVEESDEAL--VEETVEEAEGTSIPSEVVA 385
            .:..|| .|...||.:::.:.:|:            ::..|..|  |||.:...|..| .:||..
Human   237 PVCDTV-ATDLCSTGIDICSFSED------------IKPGDSLLLSVEEVLRSLETVS-NTEVCC 287

  Fly   386 EHMEEDQHLDVHTSQSPTQTEMEEAVEEHVATKTQLGHVQTELQDAESLQKDFEDAKAAAEEAKE 450
            .:::  .:|:...|..|......:::..:|...|...........|..........::.:|...|
Human   288 PNLQ--PNLEATVSNGPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSE 350

  Fly   451 KEKDLHAISAELQKEDSDEPTLKRKRTRTLKASQAAKIEPV---------PSEVKTKVQSGKGAL 506
            |.:.| .||..::     .|||......|:|......::|:         |...||.:.|.|...
Human   351 KVQPL-PISTIIR-----GPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMK 409

  Fly   507 RR---------------IRGKDKEEKVKPP---------------KPK----CRCGISGSSNTLT 537
            :.               |..|||..|.|.|               ||:    |:||.:..:.::.
Human   410 KSHEHGSKKSHSKTKPGILKKDKAVKEKIPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVL 474

  Fly   538 TCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPE 589
            |||..|||||.:..:|..|.|..|:|    .|:.:.| ..||.|.:|:...|
Human   475 TCRGQRCPCYSNRKACLDCICRGCQN----SYMANGE-KKLEAFAVPEKALE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msl-2	NP_523467.1	zf-RING_10	39..111	CDD:293290	32/72 (44%)
msl-2	NP_523467.1	MSL2-CXC	520..567	CDD:293287	19/65 (29%)
MSL2	NP_060603.2	Sufficient for interaction with MSL1. /evidence=ECO:0000269\|PubMed:23084835	1..116		41/125 (33%)
		zf-RING_10	42..111	CDD:374725	32/72 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		1/21 (5%)
		MSL2-CXC	455..509	CDD:374722	20/58 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147600
Domainoid	1	1.000	69	1.000	Domainoid score	I9676
eggNOG	1	0.900	-	-		E1_2CM0K
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8210
OMA	1	1.010	-	-		QHG47806
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006426
OrthoInspector	1	1.000	-	-		oto88479
orthoMCL	1	0.900	-	-		OOG6_108363
Panther	1	1.100	-	-	LDO	PTHR16048
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4669
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780