Protein Alignment msl-2 and MSL2

DIOPT Version :10

• Sequence 1: NP_523467.1
• Gene: msl-2 / 33565
• FlyBaseID: FBgn0005616
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: NP_060603.2
• Gene: MSL2 / 55167
• HGNCID: 25544
• Length: 577
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 139/637 - (21%)
• Similarity: 234/637 - (36%)
• Gaps: 170/637 - (26%)

  Fly     2 AQTAYLKVTRIAMRSASNLSKRRVEELNSGLGELRQLLSCVVCCQLLVDPYSPKGKRCQHNVCRL 66
            |...|:..:|:.:..... ..:...|:|..|...||.|||.||..||.||.:|....|||.||:.
Human     6 ATALYISASRLVLNYDPG-DPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNSTCQHYVCKT 69

  Fly    67 CLRGKKHLF-PSCTQCEGCSDFKTYEENRMMAAQLLCYKTLCVHLLHSALFGELAGMRPQVAREL 130
            | :|||.:. |||:.|:   |::.:|||:.::..:.|||.||.::..:.|           ||::
Human    70 C-KGKKMMMKPSCSWCK---DYEQFEENKQLSILVNCYKKLCEYITQTTL-----------ARDI 119

  Fly   131 VPRIKLPPKTTQEFIREGSNISDTFDIFLPQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHL 195
            :..:.. .......:.:||       :|..:          |..|:::..|..:|...||
Human   120 IEAVDC-SSDILALLNDGS-------LFCEE----------TEKPSDSSFTLCLTHSPLP----- 161

  Fly   196 NISDIEAEAAATAEQGHFSPLPLLPTGSRMGMLSHAGQIVIATESSESGFMDQAWTDQVDLSGTV 260
                 ......|..|...||:                        |||       |..:.:..:|
Human   162 -----STSEPTTDPQASLSPM------------------------SES-------TLSIAIGSSV 190

  Fly   261 SVSKYTNSG---NNFAVSYVMPTSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLT 322
            .....|.:|   :.|.::...|..:.|            :.:.::..:       :|.:.|..|.
Human   191 INGLPTYNGLSIDRFGINIPSPEHSNT------------IDVCNTVDI-------KTEDLSDSLP 236

  Fly   323 VLSTTVEETVETSTQLEVLTSAEEPNEISDQLANLQVEESDEAL--VEETVEEAEGTSIPSEVVA 385
            .:..|| .|...||.:::.:.:|:            ::..|..|  |||.:...|..| .:||..
Human   237 PVCDTV-ATDLCSTGIDICSFSED------------IKPGDSLLLSVEEVLRSLETVS-NTEVCC 287

  Fly   386 EHMEEDQHLDVHTSQSPTQTEMEEAVEEHVATKTQLGHVQTELQDAESLQKDFEDAKAAAEEAKE 450
            .:::  .:|:...|..|......:::..:|...|...........|..........::.:|...|
Human   288 PNLQ--PNLEATVSNGPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSE 350

  Fly   451 KEKDLHAISAELQKEDSDEPTLKRKRTRTLKASQAAKIEPV---------PSEVKTKVQSGKGAL 506
            |.:.| .||..::     .|||......|:|......::|:         |...||.:.|.|...
Human   351 KVQPL-PISTIIR-----GPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMK 409

  Fly   507 RR---------------IRGKDKEEKVKPP---------------KPK----CRCGISGSSNTLT 537
            :.               |..|||..|.|.|               ||:    |:||.:..:.::.
Human   410 KSHEHGSKKSHSKTKPGILKKDKAVKEKIPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVL 474

  Fly   538 TCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPE 589
            |||..|||||.:..:|..|.|..|:|    .|:.:.| ..||.|.:|:...|
Human   475 TCRGQRCPCYSNRKACLDCICRGCQN----SYMANGE-KKLEAFAVPEKALE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msl-2	NP_523467.1	zf-RING_10	39..111	CDD:435513	32/72 (44%)
		PTZ00341	<311..415	CDD:173534	21/105 (20%)
		MSL2-CXC	519..570	CDD:435512	20/69 (29%)
MSL2	NP_060603.2	Sufficient for interaction with MSL1. /evidence=ECO:0000269|PubMed:23084835	1..116		41/125 (33%)
		zf-RING_10	42..111	CDD:435513	32/72 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..427		1/21 (5%)
		MSL2-CXC	455..509	CDD:435512	20/58 (34%)