DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec5 and SEC5

DIOPT Version :9

Sequence 1:	NP_608780.1	Gene:	Sec5 / 33563	FlyBaseID:	FBgn0266670	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_010450.3	Gene:	SEC5 / 851744	SGDID:	S000002573	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	1049	Identity:	187/1049 - (17%)
Similarity:	350/1049 - (33%)	Gaps:	344/1049 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ETIGPLKESAVWIEESPSQN--------------------FAWG---------RRTLAQSGLTQ- 125
            :||.|...   |.::|...|                    |.:|         |..|....|:.
Yeast    18 KTINPTHS---WAQDSSKLNNEEATSNELGVETSFDILKDFKYGNQISIDKESRAYLNDESLSYI 79

  Fly   126 EDPL-GLSIEGNEQKIPED---LRDLFPEACGDLSQEHFSPAWFLLENHLATSFEDLKAGLSYLK 186
            .||| |..:....|.:|.|   |..|       ::.:.|:...||.:.|...||.||...|.
Yeast    80 RDPLNGQEMSKELQHLPNDSMRLNYL-------VNSKQFNVKAFLRDMHKQDSFNDLNNSLD--- 134

  Fly   187 RKVESQKEGQLSFLKSNAGSVIDQLDTLMNIRDKLQEDVKLHGNETLNILETSIENSIS-ESQKI 250
             :::|..:.|...||...|....:...:.|..|::.::.....||. |..::..||.|: ||...
Yeast   135 -RLDSDIQDQSIHLKQLVGKNFTKYVKIKNKLDQIYKEFDEKTNEK-NQCDSPKENQINVESLNK 197

  Fly   251 FTDVLVR------KEKADSTRSVL-------FALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSR 302
            ..|.::|      |...|:.:.:|       | :..:||.|.||.|:.|.....:::..:.:||:
Yeast   198 KVDEVIRTTTFKLKPLMDNYQKILNYQATKKF-IELNKFYFNLPKSLKRCLTNNDFNEFIIEYSK 261

  Fly   303 AKNL---FGK----TEIPIFRKVLEEVDHRILSIRKQLHEKVVKMPQSVEQQKKLIKALIS--LE 358
            ...|   |.:    ::..:.:::..::::.:::.:..:...::....:::|.::.|.:|.|  |.
Yeast   262 GLTLRRRFNQSSDASQSLVIKRIWTQIENLLVTYKDLIWNSLINSNFNIDQPQETILSLFSKLLN 326

  Fly   359 LQ----------QSGTPIGDKLRNIDP--AWDAIEAR---------------------------- 383
            |:          :||........|.:|  .|.:|:..
Yeast   327 LENFINNNQRESESGNKNTTSSSNENPILRWMSIKMNGFQNELNELSGHMISKIIHSQRLILQNN 391

  Fly   384 ------------AKYLEWTFRQTFD--QHTSKDSGAQEKAKNRDSSQAPNRVNF----------C 424
                        :.||:  ..|.|.  ..|.|||      :...|:..||:||.          |
Yeast   392 TNQDKSQGCVELSYYLK--INQLFQIISDTGKDS------EGLKSTVEPNKVNTISGTSYLNLNC 448

  Fly   425 E-------------ELCDIAASQLPDLWRLGQLYFTGELRGPHDPK--PGDFKRMVLNAIEKFCV 474
            :             |:..:....:.|||::...:..   ...|..|  .|.::..::|...|..:
Yeast   449 QPSSQGLTDSPTIIEMWLLILKYINDLWKICDQFIE---FWEHIEKFLDGTYQNSIINEKRKENI 510

  Fly   475 YLRLAILIATDQRAL-------------------------------RQS---SGLAWPIGSASAT 505
            .:..:.:|.:.|::|                               .||   |.|....|..:.:
Yeast   511 LIGDSNIIESYQKSLILKEEQINEVRLKGEEFITSVSQNLISFFTSSQSSLPSSLKDSTGDITRS 575

  Fly   506 HQ---------FLPWIPQCLRFTRIAY------------ATLISLDLPSEALDIIQKLIDEVRLF 549
            ::         |:|  |.|...:.:.|            ..|..|::.:..:.|.:..:..:...
Yeast   576 NKDSGSPLDYGFIP--PNCNGLSCLRYLPKIVEPILKFSTELAQLNITTNGITICRNTLSTIINR 638

  Fly   550 CFSII-------------------FKRATDRCKKLGSQE--TWELGVEEYPGATLLPAALETLLI 593
            |...|                   ::..|...|...|.:  |:|.||.::|
Yeast   639 CVGAISSTKLRDISNFYQLENWQVYETVTFSSKSQDSSKNLTFEYGVTQFP-------------- 689

  Fly   594 ETLDEVQSVCMQRETREGNLL-----EPQSDGQREVTQRLQEFLS--------AFSAVIEELAFH 645
            |.:...|.|.: :.||:  ||     .|..:|...|:...::.|:        :..||:|.:..:
Yeast   690 EIVTSFQEVSI-KTTRD--LLFAYEKLPIINGISVVSYPSKQLLTGIEIQQIISMEAVLEAILKN 751

  Fly   646 -SHDEETPTHNVSQLLGFPNAQQPDSVAGSGGAAAVTWEQRMLCCLANYAYCNKIFFPRLGDIF- 708
             :.|::.|.::                             ..:..|.|..|..:..||.:...|
Yeast   752 AAKDKDNPRNS-----------------------------HTILTLTNLQYFRECAFPNILQYFD 787

  Fly   709 VRYGYPLPTLAIETARYTVNQLFTNLLEEYVEHKGDPLVGTIEPSMYLGRFQW----DHEMEIGQ 769
            ..:.:.|.:..:|... .::::.:::...|:......|..|:|...:  ...|    .:...:|.
Yeast   788 DAFEWNLASKNLELFS-LLSKMESSIFGNYLSDLKINLRDTLEEKFH--EINWPMYTSNSFRVGD 849

  Fly   770 LRPYAHECCDNLVGVYSEIYSISPALLRPILESIVQTISEELARLMS-CVQRFSFTGAIQAHVDI 833
               |..|....|:.|:||.:.|.|.|:..||......|:..|..... .|...|..|::|..||:
Yeast   850 ---YIIEALMILIVVHSECFRIGPQLIHKILIETQIFIARYLFEAFKPYVGNLSNDGSLQIIVDL 911

  Fly   834 RL----------------LRDSLEG-YVNETAKNYFMEALEAINPPLSGEQKRKADEILERVKRN 881
            ..                ||..|:. :.|:|  |...:.:..|||.:|...||.|
Yeast   912 EFFQKVMGPLLEKDTEATLRACLQNCFQNDT--NRLQKCINEINPIVSANLKRTA---------- 964

  Fly   882 MRLQLLCFS 890
              :|...||
Yeast   965 --IQFAAFS 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec5	NP_608780.1	IPT_PCSR	5..85	CDD:238337
Sec5	NP_608780.1	Sec5	193..383	CDD:292108	43/224 (19%)
SEC5	NP_010450.3	Sec5	146..359	CDD:406032	41/214 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004633
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103938
Panther	1	1.100	-	-	LDO	PTHR13043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830