DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec5 and Exoc2

DIOPT Version :9

Sequence 1:	NP_608780.1	Gene:	Sec5 / 33563	FlyBaseID:	FBgn0266670	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_011242630.1	Gene:	Exoc2 / 66482	MGIID:	1913732	Length:	954	Species:	Mus musculus

Alignment Length:	928	Identity:	315/928 - (33%)
Similarity:	483/928 - (52%)	Gaps:	104/928 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PVVTGLSPKEGPPGTRVIIRGEFLGTRVQDLIGLKICGSDCLLSAEWKSPNKIIARTGPAKG-KG 68
            |:|||:||.||.|.|:|.||||.|||...|||||.|||.:|||:|||.|.:||:.|.|.||. ||
Mouse     8 PLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKIVCRVGQAKNDKG 72

  Fly    69 DIIVTTLSGGVGTSTVQFRAYH-ETIGPLKESAVWIEESPSQNFAWGRRTLAQSG-----LTQED 127
            ||||||.|||.|||||.|:... |.||.|.:||||::|   .|: :..||....|     |...:
Mouse    73 DIIVTTKSGGKGTSTVSFKLLKPEKIGILDQSAVWVDE---MNY-YDMRTDRNKGIPPLSLRPAN 133

  Fly   128 PLGLSIEGNEQKIPE-DLRDLFPEACGDLSQEHFSPAWFLLENHLATSFEDLKAGLSYLKRKVES 191
            |||:.||  :.|:|: :|..||.....|.:.|:||.||:|:|||..||||.||..::.|||:...
Mouse   134 PLGIEIE--KCKLPQKNLEVLFHGMSADFTSENFSAAWYLIENHSTTSFEQLKMAVTNLKRQANK 196

  Fly   192 QKEGQLSFLKSNAGSVIDQLDTLMNIRDKLQED--VKLHGNETLNILETSIENSISESQKIFTDV 254
            :.||.|:::|....:..:..|.|..|..||:.|  .|:.|:.|.. ||..:..:.:.:..:|.:|
Mouse   197 KSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQK-LENVLNRASNTADTLFQEV 260

  Fly   255 LVRKEKADSTRSVLFALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGKTEIPIFRKVL 319
            |.||:||||||:.|..|.|.||||.||.::.|..:.|:||:|:|||.:||:||||||:.:|:|..
Mouse   261 LGRKDKADSTRNALNVLQRFKFLFNLPLNIKRNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYY 325

  Fly   320 EEVDHRILSIRKQLHEKVVKMPQSVEQQKKLIKALISLELQQSGTPIGDKLRNIDPAWDAIEARA 384
            .||:..|..:|:.|.:|:::.|.::..||:.|:.|  .:|...|          ||||..|.|:.
Mouse   326 AEVEAGIEDLRELLLKKLLETPSTLHDQKRYIRYL--SDLHAPG----------DPAWQCIGAQH 378

  Fly   385 KYLEWTFRQTFD---QHTSKDSG-----------------------AQEKAKNRDSS-------- 415
            |   ||.:...|   .|.....|                       :|..:..|.||
Mouse   379 K---WTLKLMQDCKEGHMKSLKGHPGPHSPMLDLDNDVRPSVLGHLSQTASLKRGSSFQSGRDDT 440

  Fly   416 ---QAPNRVNFCEELCDIAASQLPDLWRLGQLYFTGELRGPHDPKPG-------------DFKRM 464
               :.|:||.|.|:|..:..||||:.|:|...|..|.|......|.|             |||:|
Mouse   441 WRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQSERSKNVRQRQNDFKKM 505

  Fly   465 VLNAIEKFCVYLRLAILIATDQRALRQSSGL---AWPIGSASATHQFLPWIPQCLRFTRIAYATL 526
            :...:......:|.|:|    ..:||:..|.   .|.: .|..:.|   |:...::..|:.|.:|
Mouse   506 IQEVMHSLVKLIRGALL----PLSLREGDGRQYGGWEV-QAELSGQ---WLAHVIQTIRLTYESL 562

  Fly   527 ISLDLPSEALDIIQKLIDEVRLFCFSIIFKRATDRCKKLGSQETWELGVEEYPGATLLPAALETL 591
            .:|::|::.|.|||.||.::|:.|..:..:...:..|:|..:|.|   |.:..|.|.||...|..
Mouse   563 TALEIPNDMLQIIQDLILDLRIRCIMVTLQHTAEEIKRLAEKEDW---VVDNEGLTSLPCQFEQS 624

  Fly   592 LIETLDEVQSVCMQRETREGNLLEPQSDGQREVTQRLQEFLSAFSAVIEELAFHSHDEETPTHNV 656
            ::.:|..::.|...:........:|::  |.||.|.....:..|...:|:|: ...|.:..|.::
Mouse   625 IVHSLQSLKGVVDCKPGEASVFQQPKT--QEEVCQLCINIMQVFIYCLEQLS-TKPDADIDTTHL 686

  Fly   657 SQLLGFPNAQQPDSVAGSGGAAAVTWEQRMLCCLANYAYCNKIFFPRLGDIFVRYGYPLPTLAIE 721
            |     .:...||.........::|.|||:|..|:|..|..:..|..:.:.|.::.:.......:
Mouse   687 S-----VDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQ 746

  Fly   722 TARYTVNQLFTNLLEEYVEHKGDPLVGTIEPSMYLGRFQWDHEMEIGQLRPYAHECCDNLVGVYS 786
            .:..::.:|...|.|.|:|.|.||:||::||.:|.|.|.|...:....:|.|..|...|::.|::
Mouse   747 VSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPAGVRNYLKEALVNIIAVHA 811

  Fly   787 EIYSISPALLRPILESIVQTISEELARLMSCVQRFSFTGAIQAHVDIRLLRDSLEGYVNETAKNY 851
            |:::||..|:..:|..:|:.:||||:|||.||..||..||:||.::|..|||::..|:...:::.
Mouse   812 EVFTISKELVPRVLARVVEAVSEELSRLMQCVSSFSRNGALQARLEICALRDTVAIYLTSESRSS 876

  Fly   852 FMEALEAINPPLSGEQKR 869
            |.:||||:....||..|:
Mouse   877 FKQALEALPQLASGADKK 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec5	NP_608780.1	IPT_PCSR	5..85	CDD:238337	54/80 (68%)
Sec5	NP_608780.1	Sec5	193..383	CDD:292108	71/191 (37%)
Exoc2	XP_011242630.1	TIG	8..91	CDD:396414	55/82 (67%)
Exoc2	XP_011242630.1	Sec5	200..376	CDD:406032	70/188 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841506
Domainoid	1	1.000	225	1.000	Domainoid score	I2536
eggNOG	1	0.900	-	-		E1_KOG2347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10122
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1393
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49407
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004633
OrthoInspector	1	1.000	-	-		oto94492
orthoMCL	1	0.900	-	-		OOG6_103938
Panther	1	1.100	-	-	LDO	PTHR13043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2519
SonicParanoid	1	1.000	-	-		X4977
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790