DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec5 and EXOC2

DIOPT Version :9

Sequence 1:	NP_608780.1	Gene:	Sec5 / 33563	FlyBaseID:	FBgn0266670	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_060773.3	Gene:	EXOC2 / 55770	HGNCID:	24968	Length:	924	Species:	Homo sapiens

Alignment Length:	944	Identity:	320/944 - (33%)
Similarity:	500/944 - (52%)	Gaps:	96/944 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PVVTGLSPKEGPPGTRVIIRGEFLGTRVQDLIGLKICGSDCLLSAEWKSPNKIIARTGPAKG-KG 68
            |:|||:||.||.|.|:|.||||.|||...|||||.|||.:|||:|||.|.:||:.|.|.||. ||
Human     8 PLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKIVCRVGQAKNDKG 72

  Fly    69 DIIVTTLSGGVGTSTVQFRAYH-ETIGPLKESAVWIEESPSQNFAWGRRTLAQSG-----LTQED 127
            ||||||.|||.|||||.|:... |.||.|.:||||::|   .|: :..||....|     |...:
Human    73 DIIVTTKSGGRGTSTVSFKLLKPEKIGILDQSAVWVDE---MNY-YDMRTDRNKGIPPLSLRPAN 133

  Fly   128 PLGLSIEGNE--QKIPEDLRDLFPEACGDLSQEHFSPAWFLLENHLATSFEDLKAGLSYLKRKVE 190
            |||:.||.::  ||   ||..||.....|.:.|:||.||:|:|||..||||.||..::.|||:..
Human   134 PLGIEIEKSKFSQK---DLEMLFHGMSADFTSENFSAAWYLIENHSNTSFEQLKMAVTNLKRQAN 195

  Fly   191 SQKEGQLSFLKSNAGSVIDQLDTLMNIRDKLQED--VKLHGNETLNILETSIENSISESQKIFTD 253
            .:.||.|:::|....:..:..|.|..|..||:.|  .|:.|:.|.. ||..:..:.:.:..:|.:
Human   196 KKSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQK-LENVLNRASNTADTLFQE 259

  Fly   254 VLVRKEKADSTRSVLFALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGKTEIPIFRKV 318
            ||.||:||||||:.|..|.|.||||.||.:::|..:.|:||:|:|||.:||:||||||:.:|:|.
Human   260 VLGRKDKADSTRNALNVLQRFKFLFNLPLNIERNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKY 324

  Fly   319 LEEVDHRILSIRKQLHEKVVKMPQSVEQQKKLIKALISLELQQSGTPIGDKLRNIDPAWDAIEAR 383
            ..||:.||.::|:.|.:|:::.|.::..||:.|:.|  .:|..||          ||||..|.|:
Human   325 YAEVETRIEALRELLLDKLLETPSTLHDQKRYIRYL--SDLHASG----------DPAWQCIGAQ 377

  Fly   384 AKY----------------------------LEWTFRQTFDQHTSKDSGAQEKA---KNRDSS-- 415
            .|:                            |:...|.:...|.|:.:..:..:   ..||.:
Human   378 HKWILQLMHSCKEGYVKDLKGNPGLHSPMLDLDNDTRPSVLGHLSQTASLKRGSSFQSGRDDTWR 442

  Fly   416 -QAPNRVNFCEELCDIAASQLPDLWRLGQLYFTGELRGPHDPKPG-------------DFKRMVL 466
             :.|:||.|.|:|..:..||||:.|:|...|..|.|......|.|             |||:|:.
Human   443 YKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQIERSKNVRQRQNDFKKMIQ 507

  Fly   467 NAIEKFCVYLRLAIL-IATDQRALRQSSGLAWPIGSASATHQFLPWIPQCLRFTRIAYATLISLD 530
            ..:.......|.|:| ::......:|..|  |.: ....:.|   |:...::..|:.:.:|.:|:
Human   508 EVMHSLVKLTRGALLPLSIRDGEAKQYGG--WEV-KCELSGQ---WLAHAIQTVRLTHESLTALE 566

  Fly   531 LPSEALDIIQKLIDEVRLFCFSIIFKRATDRCKKLGSQETWELGVEEYPGATLLPAALETLLIET 595
            :|::.|..||.||.::|:.|.....:...:..|:|..:|.|   :.:..|.|.||...|..::.:
Human   567 IPNDLLQTIQDLILDLRVRCVMATLQHTAEEIKRLAEKEDW---IVDNEGLTSLPCQFEQCIVCS 628

  Fly   596 LDEVQSVCMQRETREGNLLEPQSDGQREVTQRLQEFLSAFSAVIEELAFHSHDEETPTHNVSQLL 660
            |..::.| ::.:..|.::.: |...|.||.|.....:..|...:|:|: ...|.:..|.::|
Human   629 LQSLKGV-LECKPGEASVFQ-QPKTQEEVCQLSINIMQVFIYCLEQLS-TKPDADIDTTHLS--- 687

  Fly   661 GFPNAQQPDSVAGSGGAAAVTWEQRMLCCLANYAYCNKIFFPRLGDIFVRYGYPLPTLAIETARY 725
              .:...||.........::|.|||:|..|:|..|..:..|..:.:.|.::.:.......:.:..
Human   688 --VDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMA 750

  Fly   726 TVNQLFTNLLEEYVEHKGDPLVGTIEPSMYLGRFQWDHEMEIGQLRPYAHECCDNLVGVYSEIYS 790
            ::.:|...|.|.|:|.|.||:||::||.:|.|.|.|...:....:|.|..|...|::.|::|:::
Human   751 SLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFT 815

  Fly   791 ISPALLRPILESIVQTISEELARLMSCVQRFSFTGAIQAHVDIRLLRDSLEGYVNETAKNYFMEA 855
            ||..|:..:|..:::.:||||:|||.||..||..||:||.::|..|||::..|:...:|:.|.:|
Human   816 ISKELVPRVLSKVIEAVSEELSRLMQCVSSFSKNGALQARLEICALRDTVAVYLTPESKSSFKQA 880

  Fly   856 LEAINPPLSGEQKRKADEILERVKRNMRLQLLCF 889
            |||:....||..|:..:|:|.:.|.:|.|||.||
Human   881 LEALPQLSSGADKKLLEELLNKFKSSMHLQLTCF 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec5	NP_608780.1	IPT_PCSR	5..85	CDD:238337	54/80 (68%)
Sec5	NP_608780.1	Sec5	193..383	CDD:292108	73/191 (38%)
EXOC2	NP_060773.3	TIG	8..91	CDD:307788	55/82 (67%)
EXOC2	NP_060773.3	Sec5	198..377	CDD:317820	73/191 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151371
Domainoid	1	1.000	213	1.000	Domainoid score	I2766
eggNOG	1	0.900	-	-		E1_KOG2347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10122
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1459
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49407
OrthoDB	1	1.010	-	-		D88053at33208
OrthoFinder	1	1.000	-	-		FOG0004633
OrthoInspector	1	1.000	-	-		oto90909
orthoMCL	1	0.900	-	-		OOG6_103938
Panther	1	1.100	-	-	LDO	PTHR13043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770