DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec5 and sec-5

DIOPT Version :9

Sequence 1:	NP_608780.1	Gene:	Sec5 / 33563	FlyBaseID:	FBgn0266670	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_495958.1	Gene:	sec-5 / 174459	WormBaseID:	WBGene00004752	Length:	884	Species:	Caenorhabditis elegans

Alignment Length:	844	Identity:	237/844 - (28%)
Similarity:	382/844 - (45%)	Gaps:	147/844 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PVVTGLSPKEGPPGTRVIIRGEFLGTRVQDLIGLKICGSDCLLSAEWKSPNKIIARTGPA-KGKG 68
            |.||||||.||.|||::.||||.||....|:|.|.|||.|.|.|.:||||:|||||.|.| :|.|
Worm    13 PTVTGLSPTEGVPGTQITIRGENLGNDQSDVIMLFICGIDSLWSMKWKSPSKIIARVGAASRGPG 77

  Fly    69 DIIVTTLSGGVGTSTVQFRAYHETIGPLKESAVWIEESPSQNFAWGRRTLAQSGLTQEDPLGLSI 133
            ::.:.|.|||.|:|.|:||.:...||||:|||||::|:.:   ..||..:......|::...|.:
Worm    78 EVRIATKSGGKGSSNVKFRVFITQIGPLEESAVWVDETRT---VPGREAIRSVPQIQDERDALGL 139

  Fly   134 EGNEQKIPEDL--RDLFPEACGDLSQEHFSPAWFLLENHLATSFEDLKAGLSYLKRKVESQKEGQ 196
            ..:::::.:.|  || ||:..|:|..|:|||.|:|||||...:.|||:..:..::...:::.:..
Worm   140 LPSQKRMDQVLLSRD-FPDCSGNLRMENFSPQWYLLENHADATIEDLRIAIKNMELSKQNEAKRS 203

  Fly   197 LSFLKSNAGSVIDQLDTLMNIRDKLQEDVKLHGNETLNILETSIENSISESQKIFTDVLVRKEKA 261
            ....|:|..|:|:.:|||.|:...|::.........|..:...|::|.|:::.:|.|||.||:.|
Worm   204 EEMHKANLYSLINCVDTLANLHQALEKGENADHFAALKNISKLIKDSKSKAENVFADVLKRKDDA 268

  Fly   262 DSTRSVLFALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGKTEIPIFRKVLEEVDHRI 326
            |:||:.|..:.|.||:|.|.:.::...|.|||..::|||:|||:|:..|::|:||:::.|:|.::
Worm   269 DATRNALGVIVRFKFIFFLSSKIEDSMKKGEYITILNDYTRAKSLYADTDVPLFRELMTEIDEKM 333

  Fly   327 LSIRKQLHEKVVKMPQSVEQQKKLIKALISLELQQSGTPIGDKLRNIDPAWDAIEARAKYLEWTF 391
            ...::::..|::..|.|.|:|.||||.|..|:.:.            ||.||.|   ..|..|..
Worm   334 QVFKEEMKRKLIDTPVSYEEQSKLIKYLKILDPES------------DPTWDCI---TSYYVWLE 383

  Fly   392 RQTFDQHTSKDSGAQEKAK-----NRDSSQAPNRV--------NFCEELCDIAASQLPDLWRLGQ 443
            :..:|..|.    ..||||     |:....:.|.:        ||...|.::..|:||..|:|..
Worm   384 KSLWDMQTQ----FLEKAKLEDLENQQRINSQNHLITKTNELQNFVTTLVELLLSKLPSFWKLAN 444

  Fly   444 LYFTGELRGPHDPKPGDFKRMVLNAIEKFCVYLRLAILI--ATDQRALRQ--SSGLAWPIGSASA 504
            .|...........:..|..:|:.|.| ....:|.|..|:  |.....|:|  .....||...|..
Worm   445 TYHNSTASPDAIQRLEDINQMLTNII-NVSSWLILNALVPKALPDMVLKQYGDQFAKWPTVPADI 508

  Fly   505 THQFLPWIPQCLRFTRIAYATLISLDLPSE-ALDIIQKLID---EVRLFCFSIIFKRATDRCKKL 565
            :...|   ...|:.||    :|||..|.:: :|..:|.|::   ..||...|.......:|...|
Worm   509 SRSNL---QLSLKTTR----SLISSLLENQFSLTHVQPLVELCMTARLKLLSDFVDCGVERVALL 566

  Fly   566 GSQETWE--------------------------------LGVEEYPGATLLPA------ALETLL 592
            ..:..|:                                |.:..|||...|.:      .:..|.
Worm   567 AHRINWKQDILDRAQQTKTILPDYYENEICECLTRTRDALSISGYPGEACLFSRERFRDTIIDLF 631

  Fly   593 IETLDEVQSVCMQR---ETREGNLL-EP-QSDGQREVTQR------------LQEFLSAFSAVIE 640
            :..:..:: :|..|   ..|...|. || |..|..|:|.:            :.:.|:.....::
Worm   632 VHLITSIK-ICFDRLFIRQRPQQLAQEPGQKKGNNEITTKKLLIAVGDIEFIIAKTLNNVGKKMQ 695

  Fly   641 ELAFHSHDEETPTHNVSQLLGFPNAQQPDSVAGSGGA-----AAVTWE-------------QRML 687
            |... .|.::....:.::|..|......|.:|....|     |:.|:|             :.:|
Worm   696 ECGV-KHVDQIQEKSRAKLSAFRTKMINDCIAMMSSAFEPLIASATYEYLPDDDDISDYAKEMIL 759

  Fly   688 CCLANYAYCNKIFFPRLGDIFVRYGYPLPTLAIETARYTVNQLFTNLLEEYVEHKGD--PLVGT 749
            |.:...|..         :::.      |.||||..:.||:.....||..:.....|  ||:.|
Worm   760 CSVLQQAEL---------ELYA------PQLAIECLQQTVSNALDALLLHFSRLNQDTSPLIVT 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec5	NP_608780.1	IPT_PCSR	5..85	CDD:238337	46/80 (58%)
Sec5	NP_608780.1	Sec5	193..383	CDD:292108	62/189 (33%)
sec-5	NP_495958.1	TIG	13..95	CDD:280079	47/81 (58%)
sec-5	NP_495958.1	Sec5	201..377	CDD:292108	62/190 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161923
Domainoid	1	1.000	121	1.000	Domainoid score	I3521
eggNOG	1	0.900	-	-		E1_KOG2347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10122
Inparanoid	1	1.050	287	1.000	Inparanoid score	I1713
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49407
OrthoDB	1	1.010	-	-		D88053at33208
OrthoFinder	1	1.000	-	-		FOG0004633
OrthoInspector	1	1.000	-	-		oto19512
orthoMCL	1	0.900	-	-		OOG6_103938
Panther	1	1.100	-	-	LDO	PTHR13043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2519
SonicParanoid	1	1.000	-	-		X4977
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800