DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec5 and exoc2

DIOPT Version :9

Sequence 1:	NP_608780.1	Gene:	Sec5 / 33563	FlyBaseID:	FBgn0266670	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_956898.1	Gene:	exoc2 / 100004870	ZFINID:	ZDB-GENE-040426-1160	Length:	918	Species:	Danio rerio

Alignment Length:	952	Identity:	322/952 - (33%)
Similarity:	506/952 - (53%)	Gaps:	118/952 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PVVTGLSPKEGPPGTRVIIRGEFLGTRVQDLIGLKICGSDCLLSAEWKSPNKIIARTGPAK-GKG 68
            |:|||:||.||.|.|:|.||||.|||...|||||.|||.:|||:|||.|.:||:.|.|||| .||
Zfish     8 PLVTGISPNEGAPWTKVTIRGENLGTGPNDLIGLSICGHNCLLTAEWMSASKIVCRVGPAKDDKG 72

  Fly    69 DIIVTTLSGGVGTSTVQFRAYH-ETIGPLKESAVWIEESPSQNFAWGR-RTLAQSGLTQEDPLGL 131
            :|||||.|||.|||||.|:... |.||.|.:||||::|....:....| :.::...|...:|||:
Zfish    73 EIIVTTKSGGRGTSTVSFKLLKPERIGILDQSAVWVDELNYYDMRTDRNKGISPLSLRPANPLGI 137

  Fly   132 SIEGNEQKIP-EDLRDLFPEACGDLSQEHFSPAWFLLENHLATSFEDLKAGLSYLKRKVESQKEG 195
            .|:  ..|:| :||.::||...||.:.|:||..|:|:|||.:||||.|:||:..||::...:.||
Zfish   138 DID--RGKVPLKDLENMFPGMSGDFTSENFSATWYLIENHSSTSFEHLRAGVGNLKKQASKKNEG 200

  Fly   196 QLSFLKSNAGSVIDQLDTLMNIRDKLQED--VKLHGNETLNILETSIENSISESQKIFTDVLVRK 258
            .|:::|....:..:..|.|..|..||:.|  .|:.|:.|.. |||.:..:...:..:|.:||.||
Zfish   201 SLAYVKGGLSTFFEAQDALAAIHQKLESDGTEKVEGSMTQR-LETILNRASETADTLFQEVLGRK 264

  Fly   259 EKADSTRSVLFALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGKTEIPIFRKVLEEVD 323
            :||||||:.|..|.|.||||.||.:::|..:.|:||:|:|||.:||:|||.||:|:|:||..||:
Zfish   265 DKADSTRNALNVLQRFKFLFNLPLNIERNIQKGDYDVVINDYEKAKSLFGNTEVPVFKKVYSEVE 329

  Fly   324 HRILSIRKQLHEKVVKMPQSVEQQKKLIKALISLELQQSGTPIGDKLRNIDPAWDAIEARAKYLE 388
            .||.::||.|.:|:::.|.::..||:.|:.|  .:|...|          ||||..|.|:.|
Zfish   330 TRIEALRKLLLDKLLETPSTLHDQKRYIRYL--SDLHAPG----------DPAWQCIIAQHK--- 379

  Fly   389 WTFRQTFDQHTSKDSGAQEKAKN-----------------------------RDSS---QAPNRV 421
            |..:  ..|:..:|...::|...                             :|.|   ::|.:|
Zfish   380 WILQ--LMQNCKEDFIKEQKVGGVGLDLDRSSVLNRISLSAPVKRGGSFQTPKDDSWHYKSPQQV 442

  Fly   422 NFCEELCDIAASQLPDLWRLGQLYFTGELRGPHDPKPG--------------DFKRMVLNAIEKF 472
            .|.|:|.|:..||||:.|:|...|..|.|......|.|              |||.|:.....:.
Zfish   443 RFVEKLSDVVISQLPNFWKLWISYVNGSLFSETGEKSGQVEKLKKNARQRQNDFKGMIEEVTRRL 507

  Fly   473 CVYLRLAILIAT-DQRALRQSSGLAW----PIGSASATHQFLPWIPQCLRFTRIAYATLISLDLP 532
            ...:|.|:|.:: .:..|||..|  |    |:..|        |:.|.:...|:::..|.:|::|
Zfish   508 VQLVRGALLPSSLTELQLRQYGG--WDTKTPLTGA--------WLTQVIHTVRLSHEALSALEIP 562

  Fly   533 SEALDIIQKLIDEVRLFCFSIIFKRATDRCKKLGSQETWELGVEEYPGATLLPAALETLLIETLD 597
            ::.|.:||.|:.::|:.|.....:...:..|:|..:|.|   |.:..|.|.|||..|..:::.|
Zfish   563 NDLLQVIQDLLQDLRVHCLLTTLQHTEEDVKRLAEKEDW---VVDNEGITSLPAQFEQCMVQML- 623

  Fly   598 EVQSVCMQRETREGNLLEPQSD-GQREVTQRLQEFLSAFSAVIEELAFHSHDEETPTHNVSQLLG 661
              ||:....|.:.|.:.....| .|.:..::....:..|...:|:|:..: ||:..|.::|..|.
Zfish   624 --QSLKEPMECKPGEINISNLDVVQDKACEQCVSIMKVFIKCLEQLSTKT-DEDINTSHLSVDLT 685

  Fly   662 FPN---------AQQPDSVAGSGGAAAVTWEQRMLCCLANYAYCNKIFFPRLGDIFVRYGYPLPT 717
            .|:         :.:|              |||:|..|:|..|..:..|..|.:...:.|:.:..
Zfish   686 SPDLFGSIKEDFSSKP--------------EQRLLIILSNCQYLERHTFLNLAEHLEKNGFTMAD 736

  Fly   718 LAIETARYTVNQLFTNLLEEYVEHKGDPLVGTIEPSMYLGRFQWDHEMEIGQLRPYAHECCDNLV 782
            ..|..:...:.||..:|.|.|:|.|.||:||::|..:|.|.|.|...:....:|.|..|...:::
Zfish   737 KIIRVSIDALRQLDYDLFEMYIEKKSDPIVGSLETGIYAGYFDWKDCLLPTGVRSYLKEALVSII 801

  Fly   783 GVYSEIYSISPALLRPILESIVQTISEELARLMSCVQRFSFTGAIQAHVDIRLLRDSLEGYVNET 847
            .|::|::::|..|:..:|..|::.::||::|||.||..||..||:||.::|..|||::|.|::..
Zfish   802 SVHAEVFTVSKELVSRVLSKIIEAVAEEMSRLMQCVSSFSKNGALQARLEICALRDAIEPYLSSE 866

  Fly   848 AKNYFMEALEAINPPLSGEQKRKADEILERVKRNMRLQLLCF 889
            :...|.:||||:....||..|:..:|:|.:.|.:|:|||.||
Zfish   867 SCTSFKQALEALPQLQSGADKKLLEELLNKFKSSMKLQLNCF 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec5	NP_608780.1	IPT_PCSR	5..85	CDD:238337	54/80 (68%)
Sec5	NP_608780.1	Sec5	193..383	CDD:292108	75/191 (39%)
exoc2	NP_956898.1	TIG	8..91	CDD:280079	55/82 (67%)
exoc2	NP_956898.1	Sec5	198..377	CDD:292108	75/191 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585843
Domainoid	1	1.000	210	1.000	Domainoid score	I2771
eggNOG	1	0.900	-	-		E1_KOG2347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10122
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1346
OMA	1	1.010	-	-		QHG49407
OrthoDB	1	1.010	-	-		D88053at33208
OrthoFinder	1	1.000	-	-		FOG0004633
OrthoInspector	1	1.000	-	-		oto39620
orthoMCL	1	0.900	-	-		OOG6_103938
Panther	1	1.100	-	-	LDO	PTHR13043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2519
SonicParanoid	1	1.000	-	-		X4977
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800