Protein Alignment Cog3 and COG3

DIOPT Version :9

• Sequence 1: NP_608779.1
• Gene: Cog3 / 33562
• FlyBaseID: FBgn0031536
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_011084.1
• Gene: COG3 / 856901
• SGDID: S000000959
• Length: 801
• Species: Saccharomyces cerevisiae
• Alignment Length: 860
• Identity: 201/860 - (23%)
• Similarity: 370/860 - (43%)
• Gaps: 153/860 - (17%)

  Fly    47 NLWRDSGPSAPAPTTPTQVGPTDSS--------AAATSQSGDDIRLP--AEGLQNTN--EFLLWF 99
            :|.||.......|.:.|.||..|.|        .:...::.|.::..  :||....|  |
Yeast     8 SLVRDIASHPTIPESQTIVGLLDDSYLFDKLKKLSLAVENSDSLQRTDVSEGCSEVNGSE----- 67

  Fly   100 ADVSAEIEQRGDADYH-KYLQQLEQRKAECSHMLDQIAGAMERLGALCDEYDFVSQKTSALNTAS 163
            |..||::::.....|: .||.||..:..|...:|||.....::|.:...::..:||.|.|....:
Yeast    68 ATTSADVKKTNKYLYYTTYLDQLNIKIDEYKVVLDQTRQVNDQLDSSIKKFRKISQDTGAFIEET 132

  Fly   164 EQLIEEQERLQELSHEIQRRLHYFSQVELLNQRLQ---SPTLSVASEAFRECLNKIDECLNYIEE 225
            :.:.|:|.:|..|:..|.:.||||..::.:.:||.   ||.: |...:|...|..|||.|.:::|
Yeast   133 KTIYEKQSKLSNLTESIPKALHYFEVLDPIMRRLNHATSPAI-VKKSSFTTMLATIDESLRFLDE 196

  Fly   226 NPKFKDAAAYNVKYRQCLAKASGLVRNYVTSVINQATEATLHPKNNMPDASAALKAPDAAFALYY 290
            |...||||||.:|::|||.:|..|:.:::|:::.|..:..|....|....:........||  .|
Yeast   197 NSDLKDAAAYRIKFKQCLIRACELISHFLTNLLKQTNQEILDKTKNKNSLTGLPSTTRDAF--LY 259

  Fly   291 GKYQTAAAKVK-RVAQLIESRSEHSL-----DYAQLMADLQQHYLAQRASVMSPAVNLSIQNVKV 349
            .|:.|.|...| :|:::::..:|.:.     :...::.:...||...|..:::|.:...|..:.|
Yeast   260 SKFYTIADTFKIQVSEIVKRSNEKAYNKYHDELNSILYECFNHYFQTRLRLLTPVIWSHIDEIVV 324

  Fly   350 AHKGDH-CSLTRSACAFLVHVCQDEQRLFYQFFSTGAPHLTV---YLEGLCTILYDTMRPFIIHI 410
            ..|... ....:....:...:|.||.:||.:||........:   :|: ||..|||::|..::..
Yeast   325 KDKDQGLVKFIQDGKVYFQQLCADEYKLFVEFFPEKECRFKINQWFLQ-LCEPLYDSIRVRVLKE 388

  Fly   411 NHLETLAEICSILR-----IEMLEEHVQQNPVALEAFATIAHQ-----LLQDVQERLVFRAHLYL 465
            ..:.||.:..::..     .|..||:|:|       |..|.:.     ::|.||.||:.|..:|:
Yeast   389 TDICTLCDSVTLFAPYYEFEEGSEEYVKQ-------FTDIQYDKLFEPIVQKVQARLILRVQIYV 446

  Fly   466 QSDIQNFNP--------------------------SSGDLAYPEKLEMMESIALSLQEPA--PLR 502
            |.:|.::.|                          :|.|...|    ::||...|.:..:  |:.
Yeast   447 QQNILSYRPTRDVFMISNRRRKSKTSLQGGNEDATTSDDNPDP----LLESYLSSFKNRSILPIS 507

  Fly   503 RSDSRNSMVSSVSSAVETESVATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCVDRPIFQG 567
            .:|:.:   .|:.|...|:.::...|             :||.:.:||..||::|..::..:|..
Yeast   508 PNDADD---KSIDSEESTDKISQLQT-------------YYPPLLKTLALLSKIYEMINSVVFDD 556

  Fly   568 LSQEALKLCIQSVSHA--------AGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETS 624
            |:...:..||.|:.:|        |||...|.  :|..|..:|:||:||:.|..|.:.:||.||.
Yeast   557 LAHHVVHDCIVSLRNAYDMVIKSSAGKSDFNN--LDISLAYLKNLLMLRDSIQNFNIQYTVNETY 619

  Fly   625 LDFSKVKTAAFGLLQKRKQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIKD 689
            ||||.|:.....|.:..:.:.....::::|....|..|::..:::|:|.|:..:|::|    |||
Yeast   620 LDFSGVEGFFKSLKENGRNVLKKTKSSSILTLARELVPKVVNNMVDARTELISELRNV----IKD 680

  Fly   690 AVQMLVGPLITFLEKAQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKAK 754
                       |.|.....|...|.......:....:..||::                  |||:
Yeast   681 -----------FTESTSLELIDDTLDINSDEDLLSKNVKLREN------------------IKAR 716

  Fly   755 LAVLQRSMQLYLSNRDTEFIIFRPIRNNIIQSFVKLEQLLT---TNGYSTDDMI-------ITSC 809
            |..:...:..|:.:::....:...::..|.||:.|..:.:|   .||....|.:       :.:.
Yeast   717 LPRIYEQILNYIDDQEIVTNLLDAVQELITQSYSKYYETITELAENGKFAKDQVADVMYLDVFTD 781

  Fly   810 PSAEQVSILLSSASI 824
            ..|::|:.||.:..|
Yeast   782 FFAKEVADLLRNGDI 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog3	NP_608779.1	Sec34	117..261	CDD:282049	48/146 (33%)
COG3	NP_011084.1	Sec34	86..232	CDD:398005	48/146 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346233
Domainoid	1	1.000	113	1.000	Domainoid score	I1349
eggNOG	1	0.900	-	-		E1_KOG2604
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I886
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55042
OrthoFinder	1	1.000	-	-		FOG0004677
OrthoInspector	1	1.000	-	-		oto99797
orthoMCL	1	0.900	-	-		OOG6_103055
Panther	1	1.100	-	-	LDO	PTHR13302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R220
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830