Protein Alignment Cog3 and COG3

DIOPT Version :10

• Sequence 1: NP_608779.1
• Gene: Cog3 / 33562
• FlyBaseID: FBgn0031536
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_113619.3
• Gene: COG3 / 83548
• HGNCID: 18619
• Length: 828
• Species: Homo sapiens
• Alignment Length: 841
• Identity: 365/841 - (43%)
• Similarity: 510/841 - (60%)
• Gaps: 68/841 - (8%)

  Fly    15 RKIRNRLMQWESKTDPLAALSIQQEEHLDVLTNLWRDSGPSAPAPTTPTQVGPTDSSAAATSQ-- 77
            |..|.:|..|:.:.|..|.|:.:|.:.:..|    :.:..:.|.|...    |.:...:.|||
Human    16 RDAREKLALWDRRPDTTAPLTDRQTDSVLEL----KAAAENLPVPAEL----PIEDLCSLTSQSL 72

  Fly    78 ----------SGDDIRLPA--------EGLQNTNEFLLWFADVSAEIEQRGDADYHKYLQQLEQR 124
                      |.:||.|..        |.::...:|..|||.:..:::|.....|.:....|...
Human    73 PIELTSVVPESTEDILLKGFTSLGMEEERIETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGF 137

  Fly   125 KAECSHMLDQIAGAMERLGALCDEYDFVSQKTSALNTASEQLIEEQERLQELSHEIQRRLHYFSQ 189
            :.:|..:|:.:..|::.|.:|..:|.|||.||..|:.|.|||::||..|.:|:..||::|.||::
Human   138 QEQCDAILNDVNSALQHLESLQKQYLFVSNKTGTLHEACEQLLKEQSELVDLAENIQQKLSYFNE 202

  Fly   190 VELLNQRLQSPTLSVASEAFRECLNKIDECLNYIEENPKFKDAAAYNVKYRQCLAKASGLVRNYV 254
            :|.:|.:|.||||||.|:.|...|.|:|:|:.||..:|.|||...|.:|::|||:||..|::.|.
Human   203 LETINTKLNSPTLSVNSDGFIPMLAKLDDCITYISSHPNFKDYPIYLLKFKQCLSKALHLMKTYT 267

  Fly   255 TSVINQATEATL-HPKNNMPDASAALKAPDAAFALYYGKYQTAAAKVKRVAQLIESRSEHSLDYA 318
            .:.:...|...| ...:::|:|       |.||.|:|.|::.||.||:.:.:.||.|||...:|.
Human   268 VNTLQTLTSQLLKRDPSSVPNA-------DNAFTLFYVKFRAAAPKVRTLIEQIELRSEKIPEYQ 325

  Fly   319 QLMADLQQHYLAQRASVMSPAVNLSIQNVKVAHKGDHCSLTRSACAFLVHVCQDEQRLFYQFFST 383
            ||:.|:.|.||.||..::.|::..::..:...:..|||:|.||.|||:|||||||.:|:.:||:.
Human   326 QLLNDIHQCYLDQRELLLGPSIACTVAELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTK 390

  Fly   384 GAPHLTVYLEGLCTILYDTMRPFIIHINHLETLAEICSILRIEMLEEHVQQNPVALEAFATIAHQ 448
            ....|...||.||..|||..||.|||:.|||||:|:|.||:.|:||:|||.|...|.|||....|
Human   391 PTSKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQNNAEQLGAFAAGVKQ 455

  Fly   449 LLQDVQERLVFRAHLYLQSDIQNFNPSSGDLAYPEKLEMMESIALSLQE-----PAPLRRSD--- 505
            :|:|||||||:|.|:|:|:||..:.|:.||||||:||.|||.||.||::     |:....||
Human   456 MLEDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKKVPSEASFSDVHL 520

  Fly   506 ---SRNSMVSSVSSAVETESV--ATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCVDRPIF 565
               ..||:..|.|    |||:  ....|:    |||||||||||||||||||||:||||:||.:|
Human   521 EEGESNSLTKSGS----TESLNPRPQTTI----SPADLHGMWYPTVRRTLVCLSKLYRCIDRAVF 577

  Fly   566 QGLSQEALKLCIQSVSHAAGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETSLDFSKV 630
            ||||||||..||||:..|:..||.|||.|||:||.||||||||||||||..:||:||.|||..|.
Human   578 QGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIAPFHTEFTIKEISLDLKKT 642

  Fly   631 KTAAFGLLQKR--KQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIKDAVQM 693
            :.|||.:|...  .:.|.:.|||||:||||||||:|:||.|||:|:|||.|||.||::|:...::
Human   643 RDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHYLDSKKDVDRHLKSACEQFIQQQTKL 707

  Fly   694 LVGPLITFLEKAQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKAKLAVL 758
            .|..|..|:.|..:|...::...|:        |.|.|.|||.|.:::.:.....:.||.||.|.
Human   708 FVEQLEEFMTKVSALKTMASQGGPK--------YTLSQQPWAQPAKVNDLAATAYKTIKTKLPVT 764

  Fly   759 QRSMQLYLSNRDTEFIIFRPIRNNIIQSFVKLEQLLTTNGYSTDDMIITSCPSAEQVSILL 819
            .|||.|||||:|||||:|:|:||||.|.|.|...||... :|.:|:.|.:|||.||:|:||
Human   765 LRSMSLYLSNKDTEFILFKPVRNNIQQVFQKFHALLKEE-FSPEDIQIIACPSMEQLSLLL 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog3	NP_608779.1	Sec34	117..261	CDD:461190	56/143 (39%)
COG3	NP_113619.3	Sec34	131..274	CDD:461190	56/142 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..543		10/42 (24%)