DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cog3 and COG3

DIOPT Version :9

Sequence 1:NP_608779.1 Gene:Cog3 / 33562 FlyBaseID:FBgn0031536 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_113619.3 Gene:COG3 / 83548 HGNCID:18619 Length:828 Species:Homo sapiens


Alignment Length:841 Identity:365/841 - (43%)
Similarity:510/841 - (60%) Gaps:68/841 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 RKIRNRLMQWESKTDPLAALSIQQEEHLDVLTNLWRDSGPSAPAPTTPTQVGPTDSSAAATSQ-- 77
            |..|.:|..|:.:.|..|.|:.:|.:.:..|    :.:..:.|.|...    |.:...:.|||  
Human    16 RDAREKLALWDRRPDTTAPLTDRQTDSVLEL----KAAAENLPVPAEL----PIEDLCSLTSQSL 72

  Fly    78 ----------SGDDIRLPA--------EGLQNTNEFLLWFADVSAEIEQRGDADYHKYLQQLEQR 124
                      |.:||.|..        |.::...:|..|||.:..:::|.....|.:....|...
Human    73 PIELTSVVPESTEDILLKGFTSLGMEEERIETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGF 137

  Fly   125 KAECSHMLDQIAGAMERLGALCDEYDFVSQKTSALNTASEQLIEEQERLQELSHEIQRRLHYFSQ 189
            :.:|..:|:.:..|::.|.:|..:|.|||.||..|:.|.|||::||..|.:|:..||::|.||::
Human   138 QEQCDAILNDVNSALQHLESLQKQYLFVSNKTGTLHEACEQLLKEQSELVDLAENIQQKLSYFNE 202

  Fly   190 VELLNQRLQSPTLSVASEAFRECLNKIDECLNYIEENPKFKDAAAYNVKYRQCLAKASGLVRNYV 254
            :|.:|.:|.||||||.|:.|...|.|:|:|:.||..:|.|||...|.:|::|||:||..|::.|.
Human   203 LETINTKLNSPTLSVNSDGFIPMLAKLDDCITYISSHPNFKDYPIYLLKFKQCLSKALHLMKTYT 267

  Fly   255 TSVINQATEATL-HPKNNMPDASAALKAPDAAFALYYGKYQTAAAKVKRVAQLIESRSEHSLDYA 318
            .:.:...|...| ...:::|:|       |.||.|:|.|::.||.||:.:.:.||.|||...:|.
Human   268 VNTLQTLTSQLLKRDPSSVPNA-------DNAFTLFYVKFRAAAPKVRTLIEQIELRSEKIPEYQ 325

  Fly   319 QLMADLQQHYLAQRASVMSPAVNLSIQNVKVAHKGDHCSLTRSACAFLVHVCQDEQRLFYQFFST 383
            ||:.|:.|.||.||..::.|::..::..:...:..|||:|.||.|||:|||||||.:|:.:||:.
Human   326 QLLNDIHQCYLDQRELLLGPSIACTVAELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTK 390

  Fly   384 GAPHLTVYLEGLCTILYDTMRPFIIHINHLETLAEICSILRIEMLEEHVQQNPVALEAFATIAHQ 448
            ....|...||.||..|||..||.|||:.|||||:|:|.||:.|:||:|||.|...|.|||....|
Human   391 PTSKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQNNAEQLGAFAAGVKQ 455

  Fly   449 LLQDVQERLVFRAHLYLQSDIQNFNPSSGDLAYPEKLEMMESIALSLQE-----PAPLRRSD--- 505
            :|:|||||||:|.|:|:|:||..:.|:.||||||:||.|||.||.||::     |:....||   
Human   456 MLEDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKKVPSEASFSDVHL 520

  Fly   506 ---SRNSMVSSVSSAVETESV--ATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCVDRPIF 565
               ..||:..|.|    |||:  ....|:    |||||||||||||||||||||:||||:||.:|
Human   521 EEGESNSLTKSGS----TESLNPRPQTTI----SPADLHGMWYPTVRRTLVCLSKLYRCIDRAVF 577

  Fly   566 QGLSQEALKLCIQSVSHAAGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETSLDFSKV 630
            ||||||||..||||:..|:..||.|||.|||:||.||||||||||||||..:||:||.|||..|.
Human   578 QGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIAPFHTEFTIKEISLDLKKT 642

  Fly   631 KTAAFGLLQKR--KQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIKDAVQM 693
            :.|||.:|...  .:.|.:.|||||:||||||||:|:||.|||:|:|||.|||.||::|:...::
Human   643 RDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHYLDSKKDVDRHLKSACEQFIQQQTKL 707

  Fly   694 LVGPLITFLEKAQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKAKLAVL 758
            .|..|..|:.|..:|...::...|:        |.|.|.|||.|.:::.:.....:.||.||.|.
Human   708 FVEQLEEFMTKVSALKTMASQGGPK--------YTLSQQPWAQPAKVNDLAATAYKTIKTKLPVT 764

  Fly   759 QRSMQLYLSNRDTEFIIFRPIRNNIIQSFVKLEQLLTTNGYSTDDMIITSCPSAEQVSILL 819
            .|||.|||||:|||||:|:|:||||.|.|.|...||... :|.:|:.|.:|||.||:|:||
Human   765 LRSMSLYLSNKDTEFILFKPVRNNIQQVFQKFHALLKEE-FSPEDIQIIACPSMEQLSLLL 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cog3NP_608779.1 Sec34 117..261 CDD:282049 56/143 (39%)
COG3NP_113619.3 Sec34 131..274 CDD:309314 56/142 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..543 10/42 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159100
Domainoid 1 1.000 523 1.000 Domainoid score I300
eggNOG 1 0.900 - - E1_KOG2604
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5854
Inparanoid 1 1.050 652 1.000 Inparanoid score I789
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55042
OrthoDB 1 1.010 - - D389527at33208
OrthoFinder 1 1.000 - - FOG0004677
OrthoInspector 1 1.000 - - oto90375
orthoMCL 1 0.900 - - OOG6_103055
Panther 1 1.100 - - LDO PTHR13302
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R220
SonicParanoid 1 1.000 - - X4392
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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