DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog3 and Cog3

DIOPT Version :9

Sequence 1:	NP_608779.1	Gene:	Cog3 / 33562	FlyBaseID:	FBgn0031536	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_796355.2	Gene:	Cog3 / 338337	MGIID:	2450151	Length:	828	Species:	Mus musculus

Alignment Length:	847	Identity:	360/847 - (42%)
Similarity:	508/847 - (59%)	Gaps:	78/847 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RKIRNRLMQWESKTDPLAALSIQQE----------EHLDVLTNLWRDSGPSAPAPTTPTQVGPTD 69
            |..|.:|..|:.:.|.:|.|:.:|.          |:|.|...|..:...|..:.:.|.::
Mouse    16 RDAREKLSLWDGRPDSMAPLTDRQTDSVLELKAAVENLPVPAELPIEDVCSLASQSLPIEL---- 76

  Fly    70 SSAAATSQSGDDIRLPA--------EGLQNTNEFLLWFADVSAEIEQRGDADYHKYLQQLEQRKA 126
              .|....|.:||.|..        |.::...:|..|||.:..:::|.....|.:....|...:.
Mouse    77 --TAVVPDSTEDILLKGFTSLGMEEERIETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGFQE 139

  Fly   127 ECSHMLDQIAGAMERLGALCDEYDFVSQKTSALNTASEQLIEEQERLQELSHEIQRRLHYFSQVE 191
            :|..:|:.:..|::...:|..:|.|||.||..|:.|.|||::||..|.:|:..||::|.||:::|
Mouse   140 QCDAILNDVNSALQHQESLQKQYLFVSNKTGTLHEACEQLLKEQSELADLAEHIQQKLSYFNELE 204

  Fly   192 LLNQRLQSPTLSVASEAFRECLNKIDECLNYIEENPKFKDAAAYNVKYRQCLAKASGLVRNYVTS 256
            .:|.:|.||||||.||.|...|.|:|:|:.||..:|.|||...|.:|::|||:||..|::.|..:
Mouse   205 TINTKLNSPTLSVNSEGFIPMLAKLDDCITYISSHPNFKDYPVYLLKFKQCLSKALHLMKTYTVN 269

  Fly   257 VINQATEATL-HPKNNMPDASAALKAPDAAFALYYGKYQTAAAKVKRVAQLIESRSEHSLDYAQL 320
            .:...|...| ...:::|:|       |.||.|:|.|::.||.||:.:.:.||.|||...:|..|
Mouse   270 TLQTLTNQLLKRDPSSVPNA-------DNAFTLFYVKFRAAAPKVRTLIEQIEQRSEKIPEYQHL 327

  Fly   321 MADLQQHYLAQRASVMSPAVNLSIQNVKVAHKGDHCSLTRSACAFLVHVCQDEQRLFYQFFSTGA 385
            :.|:.|.||.||..::.|::..::..:...:..|||:|.||.|||:|||||||.:|:.:||:...
Mouse   328 LNDIHQCYLDQRELLLGPSIAYTVTELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTKPT 392

  Fly   386 PHLTVYLEGLCTILYDTMRPFIIHINHLETLAEICSILRIEMLEEHVQQNPVALEAFATIAHQLL 450
            ..|...||.||..|||..||.|||:.|||||:|:|.||:.|:||:|||.|...|.|||....|:|
Mouse   393 SKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQHNAEQLGAFAAGVKQML 457

  Fly   451 QDVQERLVFRAHLYLQSDIQNFNPSSGDLAYPEKLEMMESIALSL---QEPAP------------ 500
            :|||||||:|.|:|:|:||..:.|:.||||||:||.|||.||.||   |:.||
Mouse   458 EDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKKAPSEASFSDVRLEE 522

  Fly   501 -----LRRSDSRNSMVSSVSSAVETESVATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCV 560
                 ||:|.|.:|:.....:.:               |||||||||||||||||||||:||||:
Mouse   523 GEASGLRKSGSTDSLNPRPQTTI---------------SPADLHGMWYPTVRRTLVCLSKLYRCI 572

  Fly   561 DRPIFQGLSQEALKLCIQSVSHAAGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETSL 625
            ||.:|||||||||..||||:..|:..||.|||.|||:||.||||||||||||||..:||:||.||
Mouse   573 DRAVFQGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIAPFHTEFTIKEISL 637

  Fly   626 DFSKVKTAAFGLLQKR--KQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIK 688
            |..|.:.|||.:|...  .:.|.:.|||||:||||||||:|:||.|||:|:|||.|||.||::|:
Mouse   638 DLKKTRDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHYLDSKKDVDRHLKSACEQFIQ 702

  Fly   689 DAVQMLVGPLITFLEKAQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKA 753
            ...::.|..|..|:.|..:|...::...|:        |.|.|.|||.|.:::.::....:.||.
Mouse   703 QQTRLFVEQLEEFMTKVSALKTMASQGGPK--------YTLSQQPWAQPAKVNDLVATAYKTIKT 759

  Fly   754 KLAVLQRSMQLYLSNRDTEFIIFRPIRNNIIQSFVKLEQLLTTNGYSTDDMIITSCPSAEQVSIL 818
            ||.:..|||.|||||:|||||:|:|:||||.|.|.|...||... :|::|:.|.:|||.||:::|
Mouse   760 KLPLTLRSMALYLSNKDTEFILFKPVRNNIQQVFQKFHALLKEE-FSSEDIQIIACPSMEQLNLL 823

  Fly   819 LS 820
            ||
Mouse   824 LS 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog3	NP_608779.1	Sec34	117..261	CDD:282049	56/143 (39%)
Cog3	NP_796355.2	Sec34	131..274	CDD:282049	56/143 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849472
Domainoid	1	1.000	521	1.000	Domainoid score	I305
eggNOG	1	0.900	-	-		E1_KOG2604
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5854
Inparanoid	1	1.050	656	1.000	Inparanoid score	I769
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55042
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004677
OrthoInspector	1	1.000	-	-		oto93959
orthoMCL	1	0.900	-	-		OOG6_103055
Panther	1	1.100	-	-	LDO	PTHR13302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R220
SonicParanoid	1	1.000	-	-		X4392
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790