Protein Alignment Cog3 and cog3

DIOPT Version :9

• Sequence 1: NP_608779.1
• Gene: Cog3 / 33562
• FlyBaseID: FBgn0031536
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_596819.1
• Gene: cog3 / 2539758
• PomBaseID: SPBC1539.05
• Length: 735
• Species: Schizosaccharomyces pombe
• Alignment Length: 808
• Identity: 173/808 - (21%)
• Similarity: 342/808 - (42%)
• Gaps: 138/808 - (17%)

  Fly    10 ENENLRKIRNRLMQWESKTDPLAALSIQQEEHLDVLTNLWRDSGPSAPAPTTPTQVGPTDSSAAA 74
            :||....|:   :...:|.:.:..:....:|..|.||.:..|   |:..|..|..: |..:::..
pombe    15 DNETQNDIK---LPEVAKLENIETVHSISKERRDSLTEILND---SSSLPARPFSL-PNPNNSTV 72

  Fly    75 TSQSGDDIRLPAEGLQNTNEFLLW-FADVSAEIEQRGDADYHKYLQQLEQRKAECSHMLDQIAGA 138
            ..||    ..|.|...|.    :| .:..:..|||    |..|.:.:|:    ..::::|||.|.
pombe    73 EKQS----LFPFEEKMNP----IWIISRPTFSIEQ----DAEKKINELQ----TFTNIIDQILGQ 121

  Fly   139 MER----LGALCDEYDFVSQKTSALNTASEQLIEEQERLQELSHEIQRRLHYFSQVELLNQRLQS 199
            ...    |.::.::::...:|.|..:...|.|..::.|..|::..|::.|..|:.::.|.:..:.
pombe   122 TNNIESTLLSMKEKFESSEKKLSEFSEMCENLSTDEMRFSEIADGIRKGLTIFAPLKELTRVFRH 186

  Fly   200 PTLSVASE-AFRECLNKIDECLNYIEENPKFKDAAAYNVKYRQCLAKASGLVRNYVTSVINQATE 263
            |....|.: :|:|.:.:::.|:.::|||..|:::..|..:|::.|::|..:.:.|...:|.|.|:
pombe   187 PPPDFAGKVSFKEHITQLNTCIMFLEENLDFQESPHYLGQYKKLLSQAMDIFKPYFIRIIKQTTD 251

  Fly   264 ATLHPKNNMPDASAALKAPDAAFALYYGKYQTAAAKV-KRVAQLIESRSEHSLD-YAQLMADLQQ 326
            ..|.....| |....|.:     :|:|.::......: ..:.:|.:..|:.||| :.....|:
pombe   252 QVLKDSKKM-DVHKQLHS-----SLFYARFSAVGHNLCPTITELCKLCSKESLDAFLPAFYDV-- 308

  Fly   327 HYLAQRASVMSPAVNLSIQNVKVAHKGDHCSLTRSACAFLVHVCQDEQRLFYQFFSTGAPHLTVY 391
             |...|..::.|.::..:::..:  :....|..:.:.|.|.....||.:||.:...........|
pombe   309 -YFQCRTRLLKPVLDYHLKSFFM--EKSISSYIQKSLALLQLTFFDENKLFREILIMDDFRFMHY 370

  Fly   392 LEGLCTILYDTMRPFIIHINHLETLAEICSILR------IEMLEEHVQQ------NPVALEAFAT 444
            ...||...::..|..|:|..:|..|.|:||.::      :|...|.|.:      ||:.||
pombe   371 WNNLCQSFFENSRSLILHEKNLTELCEVCSYIQSFQNAILEGEREDVDKKVVEFLNPLVLE---- 431

  Fly   445 IAHQLLQDVQERLVFRAHLYLQSDIQNFNPSSGDLAYPEKLEMMESIALSLQEPAPLRRSDSRNS 509
                    :||||:|.....:::|||.::|:..||   ..:...:|:...|::   ||.::....
pombe   432 --------LQERLLFVVQTAIETDIQRYSPTEEDL---NPIADDKSLLFDLEK---LRLNNDEEK 482

  Fly   510 MVSSVSSAVETESVATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCVDRPIFQGLSQEALK 574
            :...|     .:.:|.|..             |||.|:::|:.||::||.|:..:|..::.|.:.
pombe   483 LDPDV-----PQKLAMAQG-------------WYPVVQKSLIILSKIYRLVNSQVFDEIALELVH 529

  Fly   575 LCIQSVSHAAGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETSLDFSKVKTAAFGLLQ 639
            .||:|:..|....|.|.......||.||:.|:|::|:..|.:.:...|..:|..||..:   :.:
pombe   530 SCIRSLVDAYRYFSRNNDKQLARLFLIKNFLVLKDQLNSFDIHYACIEAGVDLRKVWDS---VRE 591

  Fly   640 KRKQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIKDAVQMLVGPLITFLEK 704
            .|..|      ..:|:.:.|..|:...:.:|:|:|:::||:.....||:.|
pombe   592 WRSNL------RGVLQLVYETFPKFITNAVDTRQELNQQLRVAVNGYIETA-------------- 636

  Fly   705 AQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKAKLAVLQRSMQLYLSNR 769
                                   |:..:...|...:.||.:...|:  .|...|::.:.||||..
pombe   637 -----------------------VIHYTECLSIGNLESITEFQNRI--QKFPELRQQISLYLSET 676

  Fly   770 DTEFIIFRPIRNNIIQSFVKLEQLLTTN 797
            ....:..:.||..::..|....:.:..|
pombe   677 WIIELFLQAIREEVVSKFQNFYESIVAN 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog3	NP_608779.1	Sec34	117..261	CDD:282049	31/148 (21%)
cog3	NP_596819.1	Sec34	105..249	CDD:282049	31/147 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I1687
eggNOG	1	0.900	-	-		E1_KOG2604
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1279
OMA	1	1.010	-	-		QHG55042
OrthoFinder	1	1.000	-	-		FOG0004677
OrthoInspector	1	1.000	-	-		oto101462
orthoMCL	1	0.900	-	-		OOG6_103055
Panther	1	1.100	-	-	LDO	PTHR13302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R220
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900