Protein Alignment Snx1 and SNX4

DIOPT Version :10

• Sequence 1: NP_608777.1
• Gene: Snx1 / 33560
• FlyBaseID: FBgn0031534
• Length: 458
• Species: Drosophila melanogaster
• Sequence 2: XP_016862903.1
• Gene: SNX4 / 8723
• HGNCID: 11175
• Length: 482
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 116/534 - (21%)
• Similarity: 207/534 - (38%)
• Gaps: 137/534 - (25%)

  Fly     1 MEVESPEHTRD--------FAEVDINNGAATGSEDEEEEVPAPGSVTLDRN-----ESDLFVSAL 52
            ||...|:..|.        ....|...|||.|.|.|.....:.|..|:..|     :.::.||..
Human     1 MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEA 65

  Fly    53 SPSSIGDIHPLQEVLTDDGDYFISIVVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEF--STLR 115
            ...:..:...:||                         :|.||.:.|::......:|..  |..|
Human    66 EKRTGRNAMNMQE-------------------------TYTAYLIETRSVEHTDGQSVLTDSLWR 105

  Fly   116 RFSDFLGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKV--KISPQQSEPGTPMTQEWVEIRRAALE 178
            |:|:|..:...|:..|..:  ::||.|.|.   :..|  |:|....:|      ::||.||..||
Human   106 RYSEFELLRSYLLVYYPHI--VVPPLPEKR---AEFVWHKLSADNMDP------DFVERRRIGLE 159

  Fly   179 RFVHRTAQHPVLRVDLDFMNFLESDQELPRSVNTSALSGAGVIRLFNKVGETVNKITYKMDENDP 243
            .|:.|.|.||:|..|..|..||..:.....:||.:........||     :.:| .|:::...|.
Human   160 NFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRL-----KALN-ATFRVKNPDK 218

  Fly   244 WFDD---KITEVESLDANL--------------QKLHNAMKSLVTSRRELSLLTGLVAKSAAMLS 291
            .|.|   ...|::|:.::|              .|:|.....:.  |...||...|::.|..:|
Human   219 RFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVF--RHSWSLFFFLISWSYKIL- 280

  Fly   292 TCEE----HTGLSRALSNLADVEEKI-ELLRSEQANSDFF------IL------AEFIKDYLGLF 339
              |.    .:..||:.|..:.:|::: :.|:|...:.|.:      ||      |:.:|:||...
Human   281 --ERPLWFFSSSSRSKSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYA 343

  Fly   340 GAIK--CIFHERVKAFQNWQY-----AQMQLSKRRE-------NRGRFELANRADKLDQAQQEVD 390
            .|::  |..||.:      ||     ||...||:::       ....|.|.....|| ..|:..:
Human   344 EALRAVCRKHELM------QYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKL-FGQETPE 401

  Fly   391 EWQGKVQRCQQQFDDISAEIK--------------REMERFELTRVKDFKVNIIKYIEDQMAHQQ 441
            :.:.:::..::|.::...::|              .::|||:..:.:|.|..:|.|...|::..:
Human   402 QREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCK 466

  Fly   442 QIVSYW----EAFA 451
            :.:..|    |.|:
Human   467 KGIQVWTNAKECFS 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	36/131 (27%)
		BAR_SNX1_2	232..455	CDD:153307	58/286 (20%)
SNX4	XP_016862903.1	PX_SNX4	58..184	CDD:132774	40/161 (25%)
		BAR_SNX4	205..480	CDD:153306	57/287 (20%)