DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx1 and VPS5

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_014712.2	Gene:	VPS5 / 854235	SGDID:	S000005595	Length:	675	Species:	Saccharomyces cerevisiae

Alignment Length:	494	Identity:	109/494 - (22%)
Similarity:	215/494 - (43%)	Gaps:	75/494 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VESPEHTRDFAEVDINNGAATGSEDEE--EEV-------PAPGSVTLDRNESDLFVSALSPSSIG 58
            ||.|...|: ...:.|.|..|.|.::.  |:|       |..|:......|.:........:.||
Yeast   206 VEEPLDDRN-ERRENNEGKFTASVEKNILEQVDRPLYNLPQTGANISSPAEVEENSEKFGKTKIG 269

  Fly    59 D-IHPLQEVLTDDGDYFISIVVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLG 122
            . :.|.::.:.      ..:.|.||.|:|:....::.|.|.:::::.:.|.::.|  ||:.||..
Yeast   270 SKVPPTEKAVA------FKVEVKDPVKVGELTSIHVEYTVISESSLLELKYAQVS--RRYRDFRW 326

  Fly   123 IHDLLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQH 187
            ::..|...:.  |::|||.|.|..:||.|               :.::|.||..:|..:.:..|.
Yeast   327 LYRQLQNNHW--GKVIPPPPEKQSVGSFK---------------ENFIENRRFQMESMLKKICQD 374

  Fly   188 PVLRVDLDFMNFLESDQELPRSVNTSALSGAGVIRLFNKVGET-VNKITY--------------- 236
            |||:.|.||:.||.||.....|...:.|:|:|.|...|.:.|. :::|..
Yeast   375 PVLQKDKDFLLFLTSDDFSSESKKRAFLTGSGAINDSNDLSEVRISEIQLLGAEDAAEVLKNGGI 439

  Fly   237 -----------------KMDENDPWFDDKITEVESLDANLQKLHNAMKSLVTSRRELSLLT---G 281
                             |.:|.|.:|.:|..:::.|:.||:||..:::.:.|||..|:..|   .
Yeast   440 DAESHKGFMSISFSSLPKYNEADEFFIEKKQKIDELEDNLKKLSKSLEMVDTSRNTLAASTEEFS 504

  Fly   282 LVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIF 346
            .:.::.|.|:..|.:   |..|:|.|||.:.|:......:..:...:...:.||:....::|.||
Yeast   505 SMVETLASLNVSEPN---SELLNNFADVHKSIKSSLERSSLQETLTMGVMLDDYIRSLASVKAIF 566

  Fly   347 HERVKAFQNWQYAQMQLSKRRENRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIK 411
            ::|.|........:..::|:....|:......::|..:.::|....:.:....::|:..:..:||
Yeast   567 NQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRYNLTKKQWQAVGDKIK 631

  Fly   412 REMERFELTRVKDFKVNIIKYIEDQMAHQQQIVSYWEAF 450
            .|.:.|...::::|:..:...:|..:..|::.:..||.|
Yeast   632 DEFQGFSTDKIREFRNGMEISLEAAIESQKECIELWETF 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	36/127 (28%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	48/254 (19%)
VPS5	NP_014712.2	PX_Vps5p	281..390	CDD:132771	36/127 (28%)
VPS5	NP_014712.2	BAR_Vps5p	460..673	CDD:153311	46/214 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I2080
eggNOG	1	0.900	-	-		E1_COG5391
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1284
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		oto100320
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	LDO	PTHR10555
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X1340
TreeFam	1	0.960	-	-
	12	11.850