Protein Alignment Snx1 and VPS501

DIOPT Version :10

• Sequence 1: NP_608777.1
• Gene: Snx1 / 33560
• FlyBaseID: FBgn0031534
• Length: 458
• Species: Drosophila melanogaster
• Sequence 2: NP_013004.3
• Gene: VPS501 / 853953
• SGDID: S000001786
• Length: 585
• Species: Saccharomyces cerevisiae
• Alignment Length: 544
• Identity: 101/544 - (18%)
• Similarity: 196/544 - (36%)
• Gaps: 172/544 - (31%)

  Fly    17 INNGAATGSEDEEEEVPAPGSVTLDRNESD-LFVSALSPSSIGDIHPLQEVLTDDGDYFISIVVS 80
            :..|..||.:|               |.:| :|...:.|.|  |::.|::
Yeast   100 MTKGKGTGQKD---------------NINDQIFSLRILPGS--DLNSLKD--------------- 132

  Fly    81 DPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPPAPSKN 145
                      |....|::|:.::.|      :..|.||||..::..|...:.  |:.|||....|
Yeast   133 ----------SLWIIKISTQPDVEK------TIARAFSDFYWLYHQLQNNHW--GKTIPPPTRSN 179

  Fly   146 I--------IGSTKVKISPQQSEPGTPMTQEW-VEIRRAALERFVHRTAQHPVLRVDLDFMNFLE 201
            |        |....:..:.::.:|......|: :.::..|:.:.:.   ...|||:|.:|::|:.
Yeast   180 ILVEKDEFAINHLFMIRNNEKYDPIFNFKPEYIISLQLMAMIKHIF---NDKVLRLDSNFIDFIS 241

  Fly   202 SDQELPRS----VNTSALSGAGV---------IRLFNKVGETVNKIT------------------ 235
            .|.:||.|    |:.|..:|..:         ::.|:|..:.|..||
Yeast   242 WDDDLPESLQIVVDDSTFTGDKILMTSSQFRELKEFHKQSKKVESITNSHASLIPVTELTEIYIS 306

  Fly   236 ---------YK-----------MDENDPWFDDKITEVESL----------------DANLQKLHN 264
                     |:           .:.|||...:.|.:.::|                ...:|..|:
Yeast   307 PTKLFSRKDYQRLFQPQSTDNTFNNNDPLIQEWIPKSKTLFTSLSFGSSAPTYQEASTEIQACHD 371

  Fly   265 AMKSLVTSRREL--SLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFI 327
            .:.......::|  .:|..:|.::..:.|...|.|...:.:|    ::|.|      :|||:.|:
Yeast   372 WVSISKEQWKQLLYHVLQYIVDEAVKVNSVINEFTECLKQIS----LDEVI------RANSELFL 426

  Fly   328 ----LAE-FIKDYLG-----------LFG-------AIKCIFHERVKAFQNWQYAQMQLSKRRE- 368
                |.| |:|.:.|           ||.       :.:.|.::|:|..:.....::.|.|::.
Yeast   427 KFSKLNESFLKKFKGASRQDILKLIILFDENVRFCESFESILNQRLKLGKILSIIEVDLDKKKNF 491

  Fly   369 ----NRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNI 429
                :.|.....|...|:..|:.|......:..|.:|.::.|..:|..|.:.||.....:.. :.
Yeast   492 LDKLSPGNNNSNNEDLKIRTAEDEYRIVLKRYNRVKQSWEKIMEDILNERKEFEKREAAEVN-SC 555

  Fly   430 IKYIED-QMAHQQQIVSYWEAFAP 452
            :|.|.| .|..::..:..|:.|.|
Yeast   556 LKSIRDLNMDEKKHYLQLWQDFVP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	26/136 (19%)
		BAR_SNX1_2	232..455	CDD:153307	54/306 (18%)
VPS501	NP_013004.3	PX_domain	136..243	CDD:470617	25/117 (21%)
		BAR_SNX	361..580	CDD:153280	46/230 (20%)