Protein Alignment Snx1 and Snx5

DIOPT Version :10

• Sequence 1: NP_608777.1
• Gene: Snx1 / 33560
• FlyBaseID: FBgn0031534
• Length: 458
• Species: Drosophila melanogaster
• Sequence 2: NP_077187.1
• Gene: Snx5 / 69178
• MGIID: 1916428
• Length: 404
• Species: Mus musculus
• Alignment Length: 443
• Identity: 108/443 - (24%)
• Similarity: 190/443 - (42%)
• Gaps: 82/443 - (18%)

  Fly    26 EDEEEEVPAPGSVTLDRNESDLFVSALSPSSIGDIHPLQEVLTDDGDYFISIVVSDPQKIGDGMG 90
            |.:||:.....||::|.|        :.||       ||..:.|        .:|:..|:
Mouse     9 EQQEEDRSKLRSVSVDLN--------VDPS-------LQIDIPD--------ALSERDKV----- 45

  Fly    91 SYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKVKIS 155
               .:.|.|||.:..|:..|||..|:..||:.:||.|.......|.||||||:|......:.|:.
Mouse    46 ---KFTVHTKTTLSTFQSPEFSVTRQHEDFVWLHDTLTETTDYAGLIIPPAPTKPDFDGPREKMQ 107

  Fly   156 PQQSEPGTPMTQEWVEIRR--------------AALERFVHRTAQHPVLRVDLDFMNFLESDQEL 206
            ......|:...:|:.::::              :..|.|:.|.:.||||..|.:|..|||.||:|
Mouse   108 KLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSTHEVFLQRLSSHPVLSKDRNFHVFLEYDQDL 172

  Fly   207 P-RSVNTSALSGAGVIRLFNKVGETVNKITYK-MDENDPWFDDK-------ITEVESLDANLQKL 262
            . |..||..:.|.    .|..|.::.:::.:. :.|.|.:|:.:       ...::...|...|:
Mouse   173 SVRRKNTKEMFGG----FFKSVVKSADEVLFSGVKEVDDFFEQEKNFLINYYNRIKDSCAKADKM 233

  Fly   263 HNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFI 327
            ..:.|::...    .:.|.....|.|:    ||.|.:.:.|..:|::.||:..:....::.:...
Mouse   234 TRSHKNVADD----YIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLK 290

  Fly   328 LAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFELANRADKLDQAQQEVDEW 392
            |.|.::.|:....|.|.:.:.|.||..:::.:...|.|.|       |.::..||.:..|
Mouse   291 LTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKAR-------LKSKDVKLAETHQ----- 343

  Fly   393 QGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQIVS 445
                |.|.|:|:.:|...|.|:..|:..||..|:.|:|:..|.::.|.:..||
Mouse   344 ----QECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVS 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	39/141 (28%)
		BAR_SNX1_2	232..455	CDD:153307	48/222 (22%)
Snx5	NP_077187.1	PX_domain	29..169	CDD:470617	44/162 (27%)
		Interaction with DOCK1. /evidence=ECO:0000250|UniProtKB:Q9Y5X3	169..261		20/103 (19%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000250|UniProtKB:Q9Y5X3	183..200		3/20 (15%)
		BAR_SNX5	185..402	CDD:153347	50/236 (21%)