Protein Alignment Snx1 and Snx2

DIOPT Version :10

• Sequence 1: NP_608777.1
• Gene: Snx1 / 33560
• FlyBaseID: FBgn0031534
• Length: 458
• Species: Drosophila melanogaster
• Sequence 2: NP_001344392.1
• Gene: Snx2 / 67804
• MGIID: 1915054
• Length: 523
• Species: Mus musculus
• Alignment Length: 491
• Identity: 227/491 - (46%)
• Similarity: 320/491 - (65%)
• Gaps: 47/491 - (9%)

  Fly     5 SPEHTRDFAEVDI---NNGAATGS---EDEEEEV--PAPGSVTLDRNESDLFVSA--------LS 53
            |||.....|| ||   :||:....   :|:.|::  .|...|:||..|.:|.:|:        ::
Mouse    41 SPEPASLPAE-DISANSNGSKPVEVVLDDDREDLFAEATEEVSLDSPERELILSSEPSPAVTPVT 104

  Fly    54 PSSIGDIHPLQE-------VLTD----------DGDYF-ISIVVSDPQKIGDGMGSYLAYKVTTK 100
            |:::  |.|..|       |:.|          :||.| |.|.||||:|:||||.:|:||:||||
Mouse   105 PTTL--IAPRIESKSISAPVIFDRSRDEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTK 167

  Fly   101 TNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPM 165
            |::..|.:||||..||||||||:|..|..||:.:|.|:||||.|:|:|.||||:..:.|.
Mouse   168 TSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSS----- 227

  Fly   166 TQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLESDQELPRSVNTSALSGAGVIRLFNKVGET 230
            :.|:||.|||||||::.||.:||.|..|.|...|||| .||||:|||.||||||::|:.||..:.
Mouse   228 STEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLES-SELPRAVNTQALSGAGILRMVNKAADA 291

  Fly   231 VNKITYKMDENDPWFDDKITEVESLDANLQKLHNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEE 295
            |||:|.||:|:|.||::|..:.|:||..|:|||.::::||..|:|||..|...|||||||...|:
Mouse   292 VNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHASVEALVCHRKELSANTAAFAKSAAMLGNSED 356

  Fly   296 HTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQ 360
            ||.||||||.||:|||||:.|..|||.:||::.:|.:.||:.|..|:|.:|..|:|.:|.|:.||
Mouse   357 HTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQ 421

  Fly   361 MQLSKRRENRGRFELANRADKLDQA----QQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTR 421
            :.|.|:||...:..:||:.||:.||    ::|::||:.|||:.::.|:.||..|::|:.|||..|
Mouse   422 ITLLKKRETEAKMMVANKPDKIQQAKNEIREEIEEWEAKVQQGERDFEQISKTIRKEVGRFEKER 486

  Fly   422 VKDFKVNIIKYIEDQMAHQQQIVSYWEAFAPFAREI 457
            |||||..||||:|..:..|||::.|||||.|.|:.|
Mouse   487 VKDFKAVIIKYLESLVQTQQQLIKYWEAFLPEAKAI 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	70/127 (55%)
		BAR_SNX1_2	232..455	CDD:153307	110/226 (49%)
Snx2	NP_001344392.1	Sorting_nexin	3..75	CDD:461016	11/34 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..62		9/21 (43%)
		PX_SNX2	142..265	CDD:132815	71/128 (55%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000250|UniProtKB:O60749	278..295		8/16 (50%)
		BAR	283..520	CDD:472257	114/236 (48%)