DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and snx1b

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001028907.1	Gene:	snx1b / 619253	ZFINID:	ZDB-GENE-050913-82	Length:	524	Species:	Danio rerio

Alignment Length:	451	Identity:	191/451 - (42%)
Similarity:	293/451 - (64%)	Gaps:	16/451 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TRDFAEVDINNGAATGSEDEEEEVPAPGSVTLDRNESDLFVSALSPSSI-GDIHPLQEVLTDDGD 72
            |....|:.:.|..:.|    ..|:..|.:...  |.:.:..|.|.||.: ..:..|:|  .:.||
Zfish    87 TEATVELTLTNTTSQG----RREIIGPTASAC--NTTHVPNSILKPSIVTKTMEELEE--EESGD 143

  Fly    73 YF-ISIVVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGR 136
            .| ::|.|::|:||||||.:|::|||:|:|.:|.|....|:..||||||||:::.:..|...:|.
Zfish   144 QFELNIAVTNPEKIGDGMTAYMSYKVSTQTTLPMFANKTFTVRRRFSDFLGLYEKMSAKNSLMGC 208

  Fly   137 IIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLE 201
            ||||||.|:::|.||||:..:.|.     :.|:||.|||||||::.|...||.|..|.|...|||
Zfish   209 IIPPAPQKSVVGMTKVKVGKEDSS-----SAEFVEKRRAALERYLQRVVAHPSLLQDPDVREFLE 268

  Fly   202 SDQELPRSVNTSALSGAGVIRLFNKVGETVNKITYKMDENDPWFDDKITEVESLDANLQKLHNAM 266
            .| ||||:|||..|||.|::::.|:..:.|||:|.|::|:|.||:.|:.|||:.:..|::||.|:
Zfish   269 RD-ELPRAVNTQTLSGPGLLKMINRASDAVNKMTIKINESDNWFESKLQEVENEEQLLRRLHAAV 332

  Fly   267 KSLVTSRRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFILAEF 331
            .|||..|:||.:.|.:.:||.|||.:.||::.||||||.||:||:|:|.|..:||.||||||||.
Zfish   333 DSLVNHRKELCINTAVFSKSVAMLGSVEENSALSRALSQLAEVEDKMEQLHQQQAFSDFFILAEL 397

  Fly   332 IKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFELANRADKLDQAQQEVDEWQGKV 396
            :.||:.|.||::|.|.:|:|.:|..|.||:.|.|:||...:...||:.:||.||:.:::||:.||
Zfish   398 LADYVRLLGAVRCCFEQRMKVWQRLQEAQITLQKKREAEAKLLWANKPEKLQQAKDDINEWESKV 462

  Fly   397 QRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQIVSYWEAFAPFAREI 457
            .:.::.|:.::..:::|:.|||..:.:|||.:|:||:|..:..|.::|..||||.|.|:.|
Zfish   463 SQYERDFERVTCTVRKEVLRFEKEKARDFKQHIVKYLESLLHTQHRLVKCWEAFLPEAKAI 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	60/127 (47%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	99/222 (45%)
snx1b	NP_001028907.1	Sorting_nexin	43..122	CDD:281663	7/40 (18%)
		PX_domain	147..270	CDD:295365	60/127 (47%)
		BAR	288..521	CDD:299863	101/232 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2521
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2176
OMA	1	1.010	-	-		QHG53591
OrthoDB	1	1.010	-	-		D299625at33208
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		otm25276
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	O	PTHR10555
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1340
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980