DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and Snx1

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_062701.2	Gene:	Snx1 / 56440	MGIID:	1928395	Length:	521	Species:	Mus musculus

Alignment Length:	475	Identity:	203/475 - (42%)
Similarity:	302/475 - (63%)	Gaps:	32/475 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESPEHTRDFAEVDINNGAATGS--EDEEEE-----VPAPGSVTLDRNESDLFVSALSPSSIGDIH 61
            :||:.|...  ..|.||:....  ||:::|     ..|...::||..:::   ....|......|
Mouse    57 QSPKKTTSL--FPIKNGSKENGIHEDQDQEPQDLFADATVELSLDSTQNN---QKTMPGKTLTSH 116

  Fly    62 PLQEVLT-------------DDGDYF-ISIVVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFS 112
            |.||...             :..|.| :::.::||:||||||.:|:||||||:|::|.|:..:|:
Mouse   117 PPQEATNSPKPQPSYEELEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPMFRSRQFA 181

  Fly   113 TLRRFSDFLGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAAL 177
            ..||||||||:::.|..|:.:.|.|:||.|.|::||.||||:..:.|.     :.|::|.|||||
Mouse   182 VKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSS-----SAEFLEKRRAAL 241

  Fly   178 ERFVHRTAQHPVLRVDLDFMNFLESDQELPRSVNTSALSGAGVIRLFNKVGETVNKITYKMDEND 242
            ||::.|...||.:..|.|...|||. :||||:|.|.||||||::::|||..:.|:|:|.||:|:|
Mouse   242 ERYLQRIVNHPTMLQDPDVREFLEK-EELPRAVGTQALSGAGLLKMFNKATDAVSKMTIKMNESD 305

  Fly   243 PWFDDKITEVESLDANLQKLHNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLA 307
            .||::|:.|||..:..|:|||..:::||..|:||:|.|.|.|||.|||.:.|::|.||||||.||
Mouse   306 IWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTALFAKSLAMLGSSEDNTALSRALSQLA 370

  Fly   308 DVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGR 372
            :||||||.|..||||:|||:|||.:.||:.|...::..|.:|:|.:|.||.||..|.|:||:..|
Mouse   371 EVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKRESEAR 435

  Fly   373 FELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQM 437
            ...||:.|||.||:.|:.||:.:|.:.::.|:.||..:::|:.|||..:.||||.:::||:|..:
Mouse   436 LLWANKPDKLQQAKDEITEWESRVTQYERDFERISTVVRKEVTRFEKEKSKDFKNHVMKYLETLL 500

  Fly   438 AHQQQIVSYWEAFAPFAREI 457
            ..|||:..|||||.|.|:.|
Mouse   501 HSQQQLAKYWEAFLPEAKAI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	59/127 (46%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	107/222 (48%)
Snx1	NP_062701.2	COG5391	17..511	CDD:227680	203/475 (43%)
		Sorting_nexin	53..129	CDD:281663	19/92 (21%)
		PX_SNX1	144..267	CDD:132814	57/122 (47%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000250\|UniProtKB:Q13596	280..297		7/16 (44%)
		BAR_SNX1	285..518	CDD:153349	109/226 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2295
eggNOG	1	0.900	-	-		E1_COG5391
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1868
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53591
OrthoDB	1	1.010	-	-		D947320at2759
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		otm44274
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	O	PTHR10555
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X1340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870