DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and snx18a

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001093476.1	Gene:	snx18a / 562372	ZFINID:	ZDB-GENE-070705-339	Length:	567	Species:	Danio rerio

Alignment Length:	474	Identity:	104/474 - (21%)
Similarity:	171/474 - (36%)	Gaps:	138/474 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 APGSVTLDR--NESDLFVSALSPSSIGDIHPLQEV--LTDDGD-----------------YFISI 77
            |..|.|:.|  |....||     .|.|:...|.|.  ...|||                 |..|.
Zfish   164 AKSSATVSRNLNRFSTFV-----KSGGEAFVLGEASGFVKDGDKICVVMGQYGPEWQENPYPFSC 223

  Fly    78 VVSDPQKIG--DGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPP 140
            .:.||.|..  .||.||::||:|     |...:|:.:  ||:..|..::..||.|:..:.  :|.
Zfish   224 TIDDPTKQTKFKGMKSYISYKLT-----PTHTQSQVN--RRYKHFDWLYARLVEKFPVIS--VPH 279

  Fly   141 APSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVL-RVDLDFMNFL---E 201
            .|.|...|.               ..::::..||..|..:::....|||| |.|: |.:||   .
Zfish   280 IPEKQATGR---------------FEEDFISKRRRGLIWWMNHMTSHPVLARCDV-FQHFLSCSS 328

  Fly   202 SDQEL----PRSVNTSALSGAGV----------------------IRLFNKVGETVNKITYKMDE 240
            :|::.    .|......:.||..                      .::|:|          |||:
Zfish   329 TDEKAWKQGKRKAEKDEMVGANFFLTISTPPAPLDLQDVESRIDGFKVFSK----------KMDD 383

  Fly   241 NDPWFDDKITEVESLDANLQKLHNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEE------HTGL 299
            :          |..::|.|.:.  |.|.:...::|..    .|.:|...||...|      ..||
Zfish   384 S----------VIQVNATLSEF--ARKQIAGFKKEYQ----KVGQSFKYLSQAFEMDQQSYSIGL 432

  Fly   300 SRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLS 364
            ::|::...:..|.|.....||...|...:.:.:..|.|.......|.|.:..|          |:
Zfish   433 NQAIAYTGEAYEVIGDYFVEQPKQDVDPVMDLLALYQGHLTNYPDIIHVQKGA----------LT 487

  Fly   365 KRRENRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNI 429
            |.:|::...|         :.:.|.....|...||    :.||.....|::.|..|||:|||..:
Zfish   488 KVKESQKHVE---------EGKMESQHADGIRDRC----NIISFATMAEIQYFHQTRVRDFKSQM 539

  Fly   430 IKYIEDQMAHQQQIVSYWE 448
            ..:::.|::..|::....|
Zfish   540 QHFLQQQISFFQKVTGKLE 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	35/133 (26%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	48/223 (22%)
snx18a	NP_001093476.1	SH3	4..58	CDD:302595
		PX_SNX18	221..347	CDD:132819	37/150 (25%)
		BAR_SNX18	358..564	CDD:153354	50/250 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940