DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and SH3PX1

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	103/477 - (21%)
Similarity:	181/477 - (37%)	Gaps:	112/477 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EHTRDFAEVDINNGAATGSEDEEEEVPAPGSVT--LDRNESDLFVSALSPS--SIGDIHPLQEVL 67
            :.|:..|.|....|||             |:|.  :....||.::..||.:  .|.:........
  Fly   153 DDTQSLASVAGGTGAA-------------GTVKKGMFAKSSDSYILGLSSTKEKIPECEMAYITQ 204

  Fly    68 TDDGDYF-------ISIVVSDPQKIG--DGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGI 123
            .:|..|.       .|:||:.|:|..  .||.:::||::|     |.|  :..|..||:..|..:
  Fly   205 VEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLT-----PSF--NNISVSRRYKHFDWL 262

  Fly   124 HDLLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHP 188
            |:.||.|:..:.  :||.|.|.|.|..:               :::||.||..|:.||....:||
  Fly   263 HERLVDKFCLIP--VPPLPDKQISGRYE---------------EQFVEHRRVQLQEFVDWVCRHP 310

  Fly   189 VLRVDLDFMNFLE-SDQELPRS------------VN-TSALSGAGVIRLFNKVGETVNKITYKMD 239
            |:.....:.:||. .|:::.:|            || ..|:|......|.:||...|...|
  Fly   311 VISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPDKNLLHSKVDAQVELGT---- 371

  Fly   240 ENDPWFDDKITEVESLDANLQKLHN-----AMKSLVTSRRELSLL-TGL--VAKSAAM---LSTC 293
                      ..:.|:|..::.|:|     |.:|:..|::|...: .||  :||:.|:   .:..
  Fly   372 ----------QFIHSMDVAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPT 426

  Fly   294 EEHTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQY 358
            .....||.::..:..:...|.....:|...|:..|::.:..|.|:......||.....|.|..:.
  Fly   427 RNAVPLSESVGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKD 491

  Fly   359 AQMQLSKRRENRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVK 423
            .:....:.|.|..:....||                       :.|.:|..:..|:..|:..|..
  Fly   492 CEKLAGEGRMNNPQLHDVNR-----------------------RTDVVSYTVLAELTHFKSERDT 533

  Fly   424 DFKVNIIKYIEDQMAHQQQIVS 445
            ..|..:..:|.:|:...|.:|:
  Fly   534 HLKHTLKNFIAEQIKFYQGVVA 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	38/130 (29%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	40/225 (18%)
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697
		PX_SNX9_18_like	219..343	CDD:132772	40/147 (27%)
		BAR_SNX9_like	362..564	CDD:153310	43/231 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870