DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and Snx2

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_006254778.1	Gene:	Snx2 / 291464	RGDID:	1310291	Length:	523	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	225/514 - (43%)
Similarity:	316/514 - (61%)	Gaps:	66/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EVESPEHTRDFAEVDINNGAATGSEDEEEEVPA-----------PGSVTLDRNESDLF------- 48
            :.|..|...|.....::...::.|..|...:||           |..||||.:..|||
  Rat    17 DFEELEDGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGSRPVEVTLDDDREDLFAEATEEV 81

  Fly    49 ------------------VSALSPSSIGDIHPLQE-------VLTD----------DGDYF-ISI 77
                              |:.::|:::  |.|..|       |:.|          :||.| |.|
  Rat    82 SLDSPEREPIMSSEPSPAVTPITPTTL--IAPRIESKSISAPVIFDRSREEIEEEANGDIFDIEI 144

  Fly    78 VVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPPAP 142
            .||||:|:||||.:|:||:|||||::..|.:||||..||||||||:|..|..||:.:|.|:||||
  Rat   145 GVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAP 209

  Fly   143 SKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLESDQELP 207
            .|:|:|.||||:..:.|.     :.|:||.|||||||::.||.:||.|..|.|...|||| .|||
  Rat   210 EKSIVGMTKVKVGKEDSS-----STEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLES-SELP 268

  Fly   208 RSVNTSALSGAGVIRLFNKVGETVNKITYKMDENDPWFDDKITEVESLDANLQKLHNAMKSLVTS 272
            |:|||.||||||::|:.||..:.|||:|.||:|:|.||::|..:.|:||..|:|||.::::||..
  Rat   269 RAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHASVEALVCH 333

  Fly   273 RRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLG 337
            |:|||..|...|||||||...|:||.||||||.||:|||||:.|..|||.:||::.:|.:.||:.
  Rat   334 RKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIR 398

  Fly   338 LFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFELANRADKLDQA----QQEVDEWQGKVQR 398
            |..|:|.:|..|:|.:|.|:.||:.|.|:||...:..:||:.||:.||    ::|::||:.|||:
  Rat   399 LIAAVKGVFDHRMKCWQKWEDAQITLLKKRETEAKMMVANKPDKIQQAKNEIREEIEEWEAKVQQ 463

  Fly   399 CQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQIVSYWEAFAPFAREI 457
            .::.|:.||..|::|:.|||..||||||..||||:|..:..|||::.|||||.|.|:.|
  Rat   464 GERDFEQISKTIRKEVGRFEKERVKDFKAVIIKYLESLVQTQQQLIKYWEAFLPEAKAI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	70/127 (55%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	110/226 (49%)
Snx2	XP_006254778.1	Sorting_nexin	<49..112	CDD:281663	12/64 (19%)
		COG5391	51..513	CDD:227680	211/469 (45%)
		PX_SNX2	142..265	CDD:132815	71/128 (55%)
		BAR	283..520	CDD:299863	114/236 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349183
Domainoid	1	1.000	238	1.000	Domainoid score	I2224
eggNOG	1	0.900	-	-		E1_COG5391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2332
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1831
OMA	1	1.010	-	-		QHG53591
OrthoDB	1	1.010	-	-		D299625at33208
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		otm46372
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	LDO	PTHR10555
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770