DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and SNX33

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_695003.1	Gene:	SNX33 / 257364	HGNCID:	28468	Length:	574	Species:	Homo sapiens

Alignment Length:	390	Identity:	87/390 - (22%)
Similarity:	152/390 - (38%)	Gaps:	88/390 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VSDPQKIG--DGMGSYLAYKVT-TKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPP 140
            |.||.|..  .|:.||::||:| |....|.:        ||:..|..:::.|:.|:..:.  :|.
Human   234 VEDPTKQTKFKGIKSYISYKLTPTHAASPVY--------RRYKHFDWLYNRLLHKFTVIS--VPH 288

  Fly   141 APSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLE--SD 203
            .|.|...|.               ..::::|.|:..|..::.....||||.....|.:||.  .|
Human   289 LPEKQATGR---------------FEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDD 338

  Fly   204 QEL---PRSVNTSALSGAGVIRLF-------------NKVGETVNKITYKMDENDPWFDDKITEV 252
            ::.   .|......:.||..:..|             ::| :|....:.||       ||.:.::
Human   339 KQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRV-DTFKAFSKKM-------DDSVLQL 395

  Fly   253 ESLDANLQKLHNAMKSLVTSRRELSLLTG---LVAKSAAM-LSTCEEHTGLSRALSNLADVEEKI 313
            .::.:.|.:.|     :...|:|...|..   .::.|..| ...|.|  .|:.|:|:.....|.|
Human   396 STVASELVRKH-----VGGFRKEFQKLGSAFQAISHSFQMDPPFCSE--ALNSAISHTGRTYEAI 453

  Fly   314 ELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFELANR 378
            ..:.:||..:|.|.:.:.:..|.||......|.|     .|...:|:::.|:|..:.||
Human   454 GEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIH-----LQKGAFAKVKESQRMSDEGR------ 507

  Fly   379 ADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQI 443
                 ..|.|.|   |..:||:.    :...::.||..|...|..|||..:..|:..|:...|::
Human   508 -----MVQDEAD---GIRRRCRV----VGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRV 560

Fly 444 443
Human 561 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	31/128 (24%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	49/216 (23%)
SNX33	NP_695003.1	SH3_SNX33	4..58	CDD:212829
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..119
		PX_domain	230..354	CDD:295365	33/144 (23%)
		BAR_SNX33	365..571	CDD:153353	51/234 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870