DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and vps5

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_587929.1	Gene:	vps5 / 2539552	PomBaseID:	SPCPJ732.01	Length:	576	Species:	Schizosaccharomyces pombe

Alignment Length:	474	Identity:	106/474 - (22%)
Similarity:	204/474 - (43%)	Gaps:	68/474 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESPEHTRDFAEVDINNGAATGSEDEEEEVPA-----PGSVTLDRNESDLFVSALSPSSIGDIHPL 63
            |:|........||..:.|::.:.:....|.:     .||.:|...|:.....|.:|.|:...:
pombe   141 ENPTIPNSEQTVDTLDAASSSAPNFTHTVSSASSQKQGSTSLTDTENQKAHPAAAPQSLTPFY-- 203

  Fly    64 QEVLTDDGDYFISIVVSDPQKIGDGMGSYLAYKVTTKT---NIPKFKRSEFSTLRRFSDFLGIHD 125
                         |.|.||..:.:...|:..|.|:|:.   |.|..  |..:..||::||..::.
pombe   204 -------------IQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSV--SNVTVQRRYNDFAFLYQ 253

  Fly   126 LLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVL 190
            ||...:.  |.||||.|.|.::|.               ...|::|.||||||..:.:.:.||||
pombe   254 LLSNNHP--GCIIPPIPEKQVVGR---------------FDDEFIEQRRAALEVMLRKISAHPVL 301

  Fly   191 RVDLDFMNFLESDQELPRSVNTSAL------------SGAGVIRLFNKVGETVNKITYKMDENDP 243
            |.|..|..|||::...||..:.:.|            |.:|::..|.....|..  :.|..|.||
pombe   302 RDDYSFKLFLEAETFDPRMTHRTTLIESSSSPLRSGPSTSGLLDSFTSAFHTSG--SSKFSEQDP 364

  Fly   244 WFDDKITEVESLDANLQKLHNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLAD 308
            ...:....::||:..|:.:::|:...:..|.:.:.......::...||..:....||.....|:.
pombe   365 ILIEAKDTLDSLETQLKSVYHALLLSIDQRIQFASAIHDFGEAVGNLSLVDLEPTLSSKFDGLSQ 429

  Fly   309 VEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQ-------YAQMQLSKR 366
            ::.::..::..:...|...|...:::|:....:.|..|..|.|.:|.||       .|:.||.|.
pombe   430 LQVELRFVQERKVAQDNLTLGTTLEEYIRYVESAKNAFTTRQKLWQTWQSSVQAVSRAKTQLEKC 494

  Fly   367 RENRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIK 431
            ::     :..::...|...:::.::::.|....:::|.:.:..:||::.....:||.|.|.::..
pombe   495 KK-----QAKSQQKSLPYLEEQYEKYRAKAADLEKEFSESTTLLKRDLSSLTTSRVDDLKASVET 554

  Fly   432 YIEDQMAHQQQIVSYWEAF 450
            ::|..:..|::|:..||:|
pombe   555 WLESAIESQKEIIERWESF 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	43/130 (33%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	43/226 (19%)
vps5	NP_587929.1	COG5391	59..576	CDD:227680	106/474 (22%)
		PX_Vps5p	202..314	CDD:132771	43/145 (30%)
		BAR_Vps5p	361..576	CDD:153311	42/218 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	74	1.000	Domainoid score	I2542
eggNOG	1	0.900	-	-		E1_COG5391
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1473
OMA	1	1.010	-	-		QHG53591
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		oto102088
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	LDO	PTHR10555
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X1340
TreeFam	1	0.960	-	-
	13	12.860