DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx1 and Snx33

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_780692.2	Gene:	Snx33 / 235406	MGIID:	2443239	Length:	574	Species:	Mus musculus

Alignment Length:	459	Identity:	97/459 - (21%)
Similarity:	170/459 - (37%)	Gaps:	125/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GSVT-LDRNESDLFV-SALSPSSIGDIHPLQEVLTDDGDYFISIVVSDPQ----------KIGD- 87
            |||. .:.|....|| |.:....:||: |:...:.:  .|.|.:....||          .|.|
Mouse   176 GSVVGRNLNRFSCFVRSGVEAFILGDV-PMMAKIAE--TYSIEMGPRGPQWKANPHPFACSIEDP 237

  Fly    88 -------GMGSYLAYKVT-TKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIPPAPSK 144
                   |:.||::||:| |....|.:        ||:..|..:::.|:.|:..:.  :|..|.|
Mouse   238 TKQTKFKGIKSYISYKLTPTHAGSPVY--------RRYKHFDWLYNRLLHKFTVIS--VPHLPEK 292

  Fly   145 NIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLE--SDQEL- 206
            ...|.               ..::::|.|:..|..::.....||||.....|.:||.  .|::.
Mouse   293 QATGR---------------FEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWK 342

  Fly   207 --PRSVNTSALSGAGVIRLF-------------NKVGETVNKITYKMDENDPWFDDKITEVESLD 256
              .|......:.||..:..|             ::| :|....:.||       ||.:.::.::.
Mouse   343 MGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRV-DTFKAFSKKM-------DDSVLQLSNVA 399

  Fly   257 ANL------------QKLHNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADV 309
            |.|            |||.:|.:::               ..|..:........|:.|:|:....
Mouse   400 AELVRKHVGGFRKEFQKLGSAFQAI---------------SHAFQMDPPFRSDALNNAISHTGRT 449

  Fly   310 EEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFE 374
            .|.:..:.:||...|.|.:.:.:..|.||......|.|     .|...:|:::.|:|..:.||
Mouse   450 YETVGEMFAEQPKHDLFQMLDTLSLYQGLLSNFPDIIH-----LQKGAFAKVKESQRMSDEGR-- 507

  Fly   375 LANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAH 439
                     .||:|.|   |..:||:.    :...::.||..|...|..|||..:..|:..|:..
Mouse   508 ---------MAQEEAD---GIRRRCRV----VGFALQAEMNHFHQRRELDFKHMMQSYLRQQILF 556

  Fly   440 QQQI 443
            .|::
Mouse   557 YQRV 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	32/148 (22%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	47/224 (21%)
Snx33	NP_780692.2	SH3_SNX33	4..58	CDD:212829
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..116
		PX_domain	230..354	CDD:383026	31/148 (21%)
		BAR_SNX33	365..571	CDD:153353	49/242 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870