DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and snx-1

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_508216.1	Gene:	snx-1 / 180468	WormBaseID:	WBGene00004927	Length:	472	Species:	Caenorhabditis elegans

Alignment Length:	470	Identity:	156/470 - (33%)
Similarity:	264/470 - (56%)	Gaps:	34/470 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VESPE-HTRDFAEVDINNGAATGSEDEEEEVPAPGSVTLDRNESDLFVSALSPSSIGDIHPLQEV 66
            :|.|: .:.|..|:::.|          |:.| |..:.|...|..  ..:.||:.|..|....:.
Worm    20 MEQPDLFSDDCDEINLGN----------EDTP-PSKLRLHTTEEP--KESSSPAVINSIEDHDQY 71

  Fly    67 LTDDGDYF----------ISIVVSDPQKIGDGMGSYLAYKVTTK-TNIPKFKRSEFSTLRRFSDF 120
            :.:|..|.          ..:.:.:.:|.||||.:|:.||:.|: :.:..:.:..:.|.||||||
Worm    72 VGNDNHYAQISPEPALSNFKVTMREFEKRGDGMNAYIVYKLETEVSGVVGYTKQHYETWRRFSDF 136

  Fly   121 LGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRA-ALERFVHRT 184
            ||:|..:|.||:..|.:||..|.|:|...||.|.:   |:|.  |::| |.|:|| .|||::.|.
Worm   137 LGLHGKIVEKYLAKGIVIPQPPEKSISALTKTKTN---SDPA--MSRE-VGIQRARQLERYICRL 195

  Fly   185 AQHPVLRVDLDFMNFLESDQELPRSVNTSALSGAGVIRLFNKVGETVNKITYKMDENDPWFDDKI 249
            .|||.:|.|.|..:||..:.:||::|.|:|||..||.::|.......:|:.:.|:|.|.||:...
Worm   196 IQHPRMRNDCDVRDFLTIESDLPKAVQTAALSSFGVKKIFKNFQVVFSKMAFHMEEGDRWFEQVQ 260

  Fly   250 TEVESLDANLQKLHNAMKSLVTSRRELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIE 314
            ::|:.||..|:||:...::||.|||:::.....:.|:.:||:.|||.|.||||||:|.||.|.:.
Worm   261 SQVDELDEALRKLYTVTETLVASRRDMATSGEQLGKALSMLAACEESTSLSRALSSLTDVTENVS 325

  Fly   315 LLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGRFELA--N 377
            .:..:||..|....:|.|.:|:.|..|:|.:|.|||:|:|.||.||..|:::|:.:.:.:|:  .
Worm   326 AVYGKQAEVDNSKFSESIYEYIMLISALKDVFGERVRAWQQWQDAQQTLARKRDQKTKIDLSAGG 390

  Fly   378 RADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQ 442
            |.::.||.:.|:::...|:.:.:|.|.::|..|:.|:.||:..|.:|.|..:::|:|..:....:
Worm   391 RNERSDQLKGEIEDTVQKMDQLEQHFIELSKAIREEVARFDADRKQDMKKMLVEYMESMIHTHTE 455

  Fly   443 IVSYWEAFAPFAREI 457
            ::..||.|.|.|..|
Worm   456 LLHLWEKFEPEANNI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	51/129 (40%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	77/224 (34%)
snx-1	NP_508216.1	PX_domain	91..214	CDD:383026	51/128 (40%)
snx-1	NP_508216.1	BAR_SNX1_2	243..468	CDD:153307	77/224 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159570
Domainoid	1	1.000	157	1.000	Domainoid score	I2531
eggNOG	1	0.900	-	-		E1_COG5391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2332
Inparanoid	1	1.050	258	1.000	Inparanoid score	I1930
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53591
OrthoDB	1	1.010	-	-		D299625at33208
OrthoFinder	1	1.000	-	-		FOG0001310
OrthoInspector	1	1.000	-	-		oto19264
orthoMCL	1	0.900	-	-		OOG6_102065
Panther	1	1.100	-	-	LDO	PTHR10555
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X1340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840