DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx1 and Snx18

DIOPT Version :9

Sequence 1:	NP_608777.1	Gene:	Snx1 / 33560	FlyBaseID:	FBgn0031534	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_570614.2	Gene:	Snx18 / 170625	MGIID:	2137642	Length:	615	Species:	Mus musculus

Alignment Length:	472	Identity:	112/472 - (23%)
Similarity:	167/472 - (35%)	Gaps:	142/472 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 APGSVTLDR--NESDLFVSALSPSSIGDIHPLQEV--LTDDGD-----------------YFISI 77
            |..|.|:.|  |....||     .|.|:...|.|.  ...|||                 |....
Mouse   210 AKSSATVSRNLNRFSTFV-----KSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQC 269

  Fly    78 VVSDPQKIG--DGMGSYLAYK-VTTKTNIPKFKRSEFSTLRRFSDFLGIHDLLVGKYMRLGRIIP 139
            .:.||.|..  .||.||::|| |.|.|.:|        ..||:..|..::..|..|:..:.  :|
Mouse   270 TIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWLYARLAEKFPVIS--VP 324

  Fly   140 PAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFL---- 200
            ..|.|...|.               ..::::..||..|..:::..|.||||.....|.:||
Mouse   325 HLPEKQATGR---------------FEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPS 374

  Fly   201 ESDQEL----PRSVNTSALSGAGVIRLFN-------KVGETVNKI------TYKMDENDPWFDDK 248
            .:|::.    .|......:.||......:       .:.|..:||      |.|||
Mouse   375 STDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMD--------- 430

  Fly   249 ITEVESLDANLQKLHNAMKSLVTSRRELSLLTGL------VAKSAAMLSTCEE------HTGLSR 301
                   |:.||..|.|.:   .:|::   :||.      |.:|...||...|      ..||::
Mouse   431 -------DSALQLNHTANE---FARKQ---VTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQ 482

  Fly   302 ALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKR 366
            |::...|..:.|..|.:||...|...:.:.:..|.|.......|.|.:..|          |:|.
Mouse   483 AIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGA----------LTKV 537

  Fly   367 RENRGRFELANRADKLDQAQQEVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIK 431
            :|:|...|         :.:.||.:..|...||    :.||.....|:..|...||:|||
Mouse   538 KESRRHVE---------EGKMEVQKADGIQDRC----NTISFATLAEIHHFHQIRVRDFK----- 584

  Fly   432 YIEDQMAH--QQQIVSY 446
               .||.|  ||||:.:
Mouse   585 ---SQMQHFLQQQIIFF 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	33/134 (25%)
Snx1	NP_608777.1	BAR_SNX1_2	232..455	CDD:153307	59/235 (25%)
Snx18	NP_570614.2	SH3_SNX18	4..58	CDD:212830
		PX_SNX18	267..394	CDD:132819	35/151 (23%)
		BAR_SNX18	406..612	CDD:153354	60/246 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940