Protein Alignment HTR2A and htr2aa

DIOPT Version :10

• Sequence 1: NP_000612.1
• Gene: HTR2A / 3356
• HGNCID: 5293
• Length: 471
• Species: Homo sapiens
• Sequence 2: XP_689300.7
• Gene: htr2aa / 560808
• ZFINID: ZDB-GENE-070912-500
• Length: 491
• Species: Danio rerio
• Alignment Length: 490
• Identity: 289/490 - (58%)
• Similarity: 351/490 - (71%)
• Gaps: 47/490 - (9%)

Human    14 TTNSLMQLNDDTRLYSNDFNSGEA--NTSDAFN--WT--------------VDSENRTNLSCEGC 60
            |:::||..:.|:...|.|...|..  |:|...|  ||              :.||....||.:.|
Zfish    17 TSSNLMPFDPDSWTPSPDIMLGNVVHNSSIGCNRSWTDTEASLLPNLSMIGISSERTELLSSQRC 81

Human    61 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF 125
            ...:...  .|..|||:|||..||:|:|:||||||||||:||:||||||||||||||:||||||.
Zfish    82 NGETTKE--ELVRKNWAALLILVVVIVTVAGNILVIMAVNLERKLQNATNYFLMSLAVADMLLGL 144

Human   126 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRT 190
            |||||||:||:|||.||.|:.||.:|||||||||||||||||||||||||||:|||.|:|.|||:
Zfish   145 LVMPVSMVTIVYGYSWPFPASLCPMWIYLDVLFSTASIMHLCAISLDRYVAIRNPIRHNRSNSRS 209

Human   191 KAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYF 255
            :|..||.||||||.||||||||.||:|.:||||:|||||.|::||||||||:||:||||||:|||
Zfish   210 RARAKITAVWTISAGISMPIPVLGLRDHTKVFKDGSCLLTDNSFVLIGSFVAFFVPLTIMVVTYF 274

Human   256 LTIKSLQKEATLCVSDLGTRAKLA---SFSFLPQSSL--SSEKLF-QRSIHREPGSYT------- 307
            |||.:||.|||||:..|..|.|.:   :.:|||..|.  |.:||| :||:.||||:.:
Zfish   275 LTISALQSEATLCLDQLVPRPKWSTGLTLNFLPGPSFSPSEKKLFLRRSLSREPGADSGVVTPPF 339

Human   308 GRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICK-ESCNEDVIGALLNVFVWIGYL 371
            ||..||||||||||.||||:||||||||||||||||::||:|: .:||.:::..|||||||:|||
Zfish   340 GRHNMQSISNEQKASKVLGVVFFLFVVMWCPFFITNVLAVVCEPNACNANIMNRLLNVFVWVGYL 404

Human   372 SSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA 436
            ||||||||||||||||||||:|||:||:.|.|||||||||||||.:||:|:.|.:        ..
Zfish   405 SSAVNPLVYTLFNKTYRSAFARYIRCQFHEEKKPLQLILVNTIPPMAYQSTHLPL--------TG 461

Human   437 KTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 471
            ...:.|.|:....|.|....|     |.||.|||:
Zfish   462 SIGNGDFSLPLPNKNHHLSKS-----GKNESVSCL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2A	NP_000612.1	7tmA_5-HT2A	75..391	CDD:341345	234/329 (71%)
		TM helix 1	76..102	CDD:341345	18/25 (72%)
		TM helix 2	109..135	CDD:341345	22/25 (88%)
		TM helix 3	148..178	CDD:341345	27/29 (93%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	172..174		1/1 (100%)
		TM helix 4	190..213	CDD:341345	16/22 (73%)
		TM helix 5	231..260	CDD:341345	23/28 (82%)
		TM helix 6	316..346	CDD:341345	26/29 (90%)
		TM helix 7	359..384	CDD:341345	21/24 (88%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	376..380		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..471		7/19 (37%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405	469..471		1/1 (100%)
htr2aa	XP_689300.7	7tm_GPCRs	94..424	CDD:475119	234/329 (71%)
		TM helix 1	96..120	CDD:410628	17/23 (74%)
		TM helix 2	129..151	CDD:410628	19/21 (90%)
		TM helix 3	168..190	CDD:410628	19/21 (90%)
		TM helix 4	213..229	CDD:410628	12/15 (80%)
		TM helix 5	251..274	CDD:410628	17/22 (77%)
		TM helix 6	354..376	CDD:410628	19/21 (90%)
		TM helix 7	392..417	CDD:410628	21/24 (88%)