DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2A and 5-HT2B

DIOPT Version :10

Sequence 1:NP_000612.1 Gene:HTR2A / 3356 HGNCID:5293 Length:471 Species:Homo sapiens
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:943 Identity:175/943 - (18%)
Similarity:261/943 - (27%) Gaps:544/943 - (57%)


- Green bases have known domain annotations that are detailed below.


Human     3 ILCEENTSLSSTTNSLMQLNDDTRLYSNDFN-SGEANTSDAFNWTVDSENRTNLSCEGCLSPSCL 66
            :|.||:.:..:|.|:..:.|   :|:...:| :|.|..|..|.......|               
  Fly    27 VLWEEDETQRTTANATSRHN---QLHVARWNATGNATISATFEDVPFDAN--------------- 73

Human    67 SLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVS 131
                    |:.|||..|:::.|.||||||.:|::.|::|||.||||||||||.|:::..||||:.
  Fly    74 --------NYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLG 130

Human   132 MLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKI 196
            :||::.|| :||.|:.|..||.|||||.||||||||.||:|||::::.|:...|..:|.:..|||
  Fly   131 ILTLVKGY-FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKI 194

Human   197 IAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261
            :.||.:|:.:|:|:.:...::.:.|...|:|.:.|..:.|:||.|.|:|||.:|::||.||::.|
  Fly   195 VFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLL 259

Human   262 QKE-------------------------------------------------------------- 264
            .::                                                              
  Fly   260 ARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLS 324

Human   265 ----------------------------------------------------------------- 264
                                                                             
  Fly   325 TLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQ 389

Human   265 -----------------------------------------------ATLCVSDLGTRAKLAS-- 280
                                                           .||.:....||..|||  
  Fly   390 YPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSR 454

Human   281 ---------FSFLPQ--------------------------------------------SSLSSE 292
                     .|.|.|                                            :||...
  Fly   455 MGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKN 519

Human   293 KLFQR------------------------------------------------------------ 297
            .|:.|                                                            
  Fly   520 ALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQL 584

Human   298 ----------------------------------------------------------------- 297
                                                                             
  Fly   585 PSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSA 649

Human   298 ---------------------SIHREPGSYT-----------------GRR-------------- 310
                                 |.|.:..|.|                 |||              
  Fly   650 GITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWD 714

Human   311 ---------------------------------------TMQSISN------------------- 317
                                                   |::|..|                   
  Fly   715 SSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSS 779

Human   318 ----------------------------------EQKACKVLGIVFFLFVVMWCPFFITNIMAVI 348
                                              ||||.||||:|||.||::|.|||:.|::..:
  Fly   780 PCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTV 844

Human   349 CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNT 413
            |.| |.|.:...:.:|..|:||.||.|||:.||:|||.:|.||.:.:.|:|....          
  Fly   845 CAE-CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTS---------- 898

Human   414 IPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMV 446
                |::.|:.|...|...   .||..:.|:.|
  Fly   899 ----AWRPSRXQTPVKPGK---LKTNTHKCASV 924

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2ANP_000612.1 7tmA_5-HT2A 75..391 CDD:341345 150/813 (18%)
TM helix 1 76..102 CDD:341345 12/25 (48%)
TM helix 2 109..135 CDD:341345 16/25 (64%)
TM helix 3 148..178 CDD:341345 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 8/22 (36%)
TM helix 5 231..260 CDD:341345 14/28 (50%)
TM helix 6 316..346 CDD:341345 19/82 (23%)
TM helix 7 359..384 CDD:341345 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..471
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405 469..471
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 89/193 (46%)
TM helix 1 75..101 CDD:320433 12/25 (48%)
TM helix 2 108..134 CDD:320433 16/25 (64%)
TM helix 3 146..176 CDD:320433 21/29 (72%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 14/28 (50%)
7tm_GPCRs <799..893 CDD:475119 39/94 (41%)
TM helix 6 818..840 CDD:410628 13/21 (62%)
TM helix 7 854..879 CDD:410628 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

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