DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2A and Htr2a

DIOPT Version :10

Sequence 1:NP_000612.1 Gene:HTR2A / 3356 HGNCID:5293 Length:471 Species:Homo sapiens
Sequence 2:NP_058950.1 Gene:Htr2a / 29595 RGDID:61800 Length:471 Species:Rattus norvegicus


Alignment Length:471 Identity:430/471 - (91%)
Similarity:448/471 - (95%) Gaps:0/471 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC 65
            |:||||:|.||||..||||||.|..|||.|||||.:||||:|.|||:|:||||||||||.|.|:|
  Rat     1 MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTC 65

Human    66 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
            ||:|||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 LSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130

Human   131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 SMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195

Human   196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKS 260
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
  Rat   196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKS 260

Human   261 LQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVL 325
            ||||||||||||.|||||||||||||||||||||||||||||||||.||||||||||||||||||
  Rat   261 LQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVL 325

Human   326 GIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
  Rat   326 GIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390

Human   391 FSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEE 455
            ||||||||||||:||||||||||||||||||||||:||||||::||:.|.:|||||.||||.|||
  Rat   391 FSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEE 455

Human   456 ASKDNSDGVNEKVSCV 471
            ...||.:.||||||||
  Rat   456 NCTDNIETVNEKVSCV 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2ANP_000612.1 7tmA_5-HT2A 75..391 CDD:341345 309/315 (98%)
TM helix 1 76..102 CDD:341345 24/25 (96%)
TM helix 2 109..135 CDD:341345 25/25 (100%)
TM helix 3 148..178 CDD:341345 28/29 (97%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 22/22 (100%)
TM helix 5 231..260 CDD:341345 27/28 (96%)
TM helix 6 316..346 CDD:341345 29/29 (100%)
TM helix 7 359..384 CDD:341345 24/24 (100%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..471 12/19 (63%)
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405 469..471 1/1 (100%)
Htr2aNP_058950.1 7tmA_5-HT2A 75..391 CDD:341345 309/315 (98%)
TM helix 1 76..102 CDD:341345 24/25 (96%)
TM helix 2 109..135 CDD:341345 25/25 (100%)
TM helix 3 148..178 CDD:341345 28/29 (97%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 22/22 (100%)
TM helix 5 231..260 CDD:341345 27/28 (96%)
TM helix 6 316..346 CDD:341345 29/29 (100%)
TM helix 7 359..384 CDD:341345 24/24 (100%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 3/3 (100%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 469..471 1/1 (100%)

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