DRSC/TRiP Functional Genomics Resources

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Protein Alignment HTR2A and ser-1

DIOPT Version :10

Sequence 1:NP_000612.1 Gene:HTR2A / 3356 HGNCID:5293 Length:471 Species:Homo sapiens
Sequence 2:NP_001024728.1 Gene:ser-1 / 181716 WormBaseID:WBGene00004776 Length:683 Species:Caenorhabditis elegans


Alignment Length:473 Identity:126/473 - (26%)
Similarity:220/473 - (46%) Gaps:95/473 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLP 144
            |..|:.::.:.||.||.:|::.:::|.|.|||||.|||:||:|:..:|||:|::..:....|...
 Worm    61 LLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWS 125

Human   145 SKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMP 209
            ..:|.:::|.||...:|||:|:..||||||:.|..|: .:|..|:|..|:||..||.:::.:|.|
 Worm   126 VSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPL-RTRNRSKTLIFIKIAIVWVVTLLVSCP 189

Human   210 IPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGT 274
            |.|..:.|.:.:.:...|::....:::.||.::|.|||.||.:||..|.:.|.|:|::.....|.
 Worm   190 IAVLAMHDTANILRNNQCMIFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQASILSQKAGD 254

Human   275 R---------------------------------------AKLASFSFL-------------PQS 287
            :                                       ..::|.|.:             |..
 Worm   255 KFNGNGLRRTMPHRKLGYARTYSATVNGTIANGKAIGAHGRTMSSISNIANGETADRLGTSRPSI 319

Human   288 SLSSEKLFQR------------SIHREPGSYTGRRT-----MQSISNEQKACKVLGIVFFLFVVM 335
            :.:..|..|:            ::.....:..|||:     .|.::||.||.:||.:||..|.:.
 Worm   320 NTNGHKQLQKASTINKWKSRTSNLVTNFANKVGRRSSLQTATQDLANEHKATRVLAVVFACFFIC 384

Human   336 WCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQ-- 398
            |.|||..|.:.....|  |..:...:.::|:|:||:||.:||::||:|||.:|.||.|.::||  
 Worm   385 WTPFFFINFLIGFGGE--NVQIPDWVASIFLWLGYVSSTINPIIYTVFNKRFRQAFVRILRCQCF 447

Human   399 ---------YKENKKPLQLILVNTIPALAYKSSQLQMGQ-----KKNSKQDAKTTDNDCSMVALG 449
                     |..|       ...||....|..|:....:     .::..:.|::::......|..
 Worm   448 HPLRDSHQMYSRN-------FTTTIVPDTYTCSRSNQERTTSVITRDETRSARSSERPEPSRARS 505

Human   450 KQHSEEASKDNSDGVNEK 467
            :...|..::.|....:||
 Worm   506 EISEEPVARTNGKLTSEK 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTR2ANP_000612.1 7tmA_5-HT2A 75..391 CDD:341345 109/379 (29%)
TM helix 1 76..102 CDD:341345 7/21 (33%)
TM helix 2 109..135 CDD:341345 15/25 (60%)
TM helix 3 148..178 CDD:341345 14/29 (48%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 9/22 (41%)
TM helix 5 231..260 CDD:341345 11/28 (39%)
TM helix 6 316..346 CDD:341345 14/29 (48%)
TM helix 7 359..384 CDD:341345 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..471 4/17 (24%)
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405 469..471
ser-1NP_001024728.1 7tmA_5-HT2 56..438 CDD:320180 109/379 (29%)
TM helix 1 57..83 CDD:320180 7/21 (33%)
TM helix 2 90..116 CDD:320180 15/25 (60%)
TM helix 3 129..159 CDD:320180 14/29 (48%)
TM helix 4 170..193 CDD:320180 9/22 (41%)
TM helix 5 211..240 CDD:320180 11/28 (39%)
TM helix 6 365..395 CDD:320180 14/29 (48%)
TM helix 7 406..431 CDD:320180 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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