Protein Alignment HTR2A and Htr2a

DIOPT Version :10

• Sequence 1: NP_000612.1
• Gene: HTR2A / 3356
• HGNCID: 5293
• Length: 471
• Species: Homo sapiens
• Sequence 2: NP_766400.1
• Gene: Htr2a / 15558
• MGIID: 109521
• Length: 471
• Species: Mus musculus
• Alignment Length: 471
• Identity: 431/471 - (91%)
• Similarity: 449/471 - (95%)
• Gaps: 0/471 - (0%)

Human     1 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC 65
            |:||||:|.||||..||||||.||:|||.|||||.:||||:|.|||:|:||||||||||.|.|:|
Mouse     1 MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTC 65

Human    66 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
            ||:|||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 LSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130

Human   131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195

Human   196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKS 260
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKS 260

Human   261 LQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVL 325
            ||||||||||||.|||||:|||||||||||||||||||||||||||.||||||||||||||||||
Mouse   261 LQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVL 325

Human   326 GIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse   326 GIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390

Human   391 FSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEE 455
            ||||||||||||:||||||||||||.|||||||||:||||||::||:.|.||||||.||.|||||
Mouse   391 FSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEE 455

Human   456 ASKDNSDGVNEKVSCV 471
            ...||.:.||||||||
Mouse   456 MCTDNIETVNEKVSCV 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2A	NP_000612.1	7tmA_5-HT2A	75..391	CDD:341345	309/315 (98%)
		TM helix 1	76..102	CDD:341345	24/25 (96%)
		TM helix 2	109..135	CDD:341345	25/25 (100%)
		TM helix 3	148..178	CDD:341345	29/29 (100%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	172..174		1/1 (100%)
		TM helix 4	190..213	CDD:341345	22/22 (100%)
		TM helix 5	231..260	CDD:341345	27/28 (96%)
		TM helix 6	316..346	CDD:341345	29/29 (100%)
		TM helix 7	359..384	CDD:341345	24/24 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	376..380		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..471		13/19 (68%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405	469..471		1/1 (100%)
Htr2a	NP_766400.1	7tmA_5-HT2A	75..391	CDD:341345	309/315 (98%)
		TM helix 1	76..102	CDD:341345	24/25 (96%)
		TM helix 2	109..135	CDD:341345	25/25 (100%)
		TM helix 3	148..178	CDD:341345	29/29 (100%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	172..174		1/1 (100%)
		TM helix 4	190..213	CDD:341345	22/22 (100%)
		TM helix 5	231..260	CDD:341345	27/28 (96%)
		TM helix 6	316..346	CDD:341345	29/29 (100%)
		TM helix 7	359..384	CDD:341345	24/24 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	376..380		3/3 (100%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223	469..471		1/1 (100%)