DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HTR2A and htr2a

DIOPT Version :9

Sequence 1:	NP_000612.1	Gene:	HTR2A / 3356	HGNCID:	5293	Length:	471	Species:	Homo sapiens
Sequence 2:	XP_017947163.1	Gene:	htr2a / 100492782	XenbaseID:	XB-GENE-986221	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	342/471 - (72%)
Similarity:	391/471 - (83%)	Gaps:	10/471 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC 65
            ||:...:| .::.|.:||:::|.|.|.|.:|..:...|||:..|||:.|||.|:|:.||    |.
Frog    23 MDLHDNQN-FVNFTKSSLIEINHDRRFYRSDMLATGVNTSEILNWTMASENLTHLTTEG----SK 82

Human    66 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
            .||    ||||.||||..||::|||||||||||||||||||||||||||||||||||||||||||
Frog    83 FSL----EKNWPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 143

Human   131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195
            |||.||..|.|||..|||.|||||||||||||||||||||||||:||:||||||||||||||..|
Frog   144 SMLNILNDYEWPLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKALAK 208

Human   196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKS 260
            ||||||||||||||:||||||||||||.:.:|.|:|:||::|||||:|||||.||||||||||||
Frog   209 IIAVWTISVGISMPVPVFGLQDDSKVFDQENCSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKS 273

Human   261 LQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVL 325
            ||||||||:::||.::|||.||||||||:|||||||||:.:|...| ||:|||||||||||.|||
Frog   274 LQKEATLCINNLGAKSKLALFSFLPQSSISSEKLFQRSLQKELAPY-GRKTMQSISNEQKASKVL 337

Human   326 GIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390
            ||||||||:|||||||||:|||.|||||||.|||.||.|||||||||||||||||||||:|||||
Frog   338 GIVFFLFVIMWCPFFITNVMAVFCKESCNEHVIGELLKVFVWIGYLSSAVNPLVYTLFNQTYRSA 402

Human   391 FSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEE 455
            |||||||:|:|.|||||||||||||||||.|||||:.|.|:.|::.|...||.|:|.:|.|..:.
Frog   403 FSRYIQCRYREEKKPLQLILVNTIPALAYNSSQLQLAQMKSLKKEGKMKTNDYSLVTIGLQPLDR 467

Human   456 ASKDNSDGVNEKVSCV 471
            |||.....:||.|||:
Frog   468 ASKTGVAPLNENVSCL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HTR2A	NP_000612.1	7tmA_5-HT2A	75..391	CDD:341345	263/315 (83%)
		TM helix 1	77..101	CDD:341345	18/23 (78%)
		TM helix 2	110..132	CDD:341345	21/21 (100%)
		TM helix 3	149..171	CDD:341345	20/21 (95%)
		Agonist binding. /evidence=ECO:0000250\|UniProtKB:P41595	155..160		4/4 (100%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250\|UniProtKB:P41595	172..174		1/1 (100%)
		TM helix 4	194..210	CDD:341345	14/15 (93%)
		TM helix 5	232..255	CDD:341345	17/22 (77%)
		TM helix 6	322..344	CDD:341345	19/21 (90%)
		Agonist binding. /evidence=ECO:0000250\|UniProtKB:P41595	336..340		3/3 (100%)
		TM helix 7	359..384	CDD:341345	22/24 (92%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250\|UniProtKB:P41595	376..380		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..471		8/20 (40%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11150294, ECO:0000269\|PubMed:14988405	469..471		1/1 (100%)
htr2a	XP_017947163.1	7tm_GPCRs	88..403	CDD:391938	263/315 (83%)
		TM helix 1	90..114	CDD:341315	18/23 (78%)
		TM helix 2	123..145	CDD:341315	21/21 (100%)
		TM helix 3	162..184	CDD:341315	20/21 (95%)
		TM helix 4	207..223	CDD:341315	14/15 (93%)
		TM helix 5	245..268	CDD:341315	17/22 (77%)
		TM helix 6	331..356	CDD:341315	22/24 (92%)
		TM helix 7	371..396	CDD:341315	22/24 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I3917
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68073
Inparanoid	1	1.050	663	1.000	Inparanoid score	I5742
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129874at32523
OrthoFinder	1	1.000	-	-		FOG0001488
OrthoInspector	1	1.000	-	-		oto158521
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060