Protein Alignment HTR2A and htr2a

DIOPT Version :10

• Sequence 1: NP_000612.1
• Gene: HTR2A / 3356
• HGNCID: 5293
• Length: 471
• Species: Homo sapiens
• Sequence 2: XP_017947163.1
• Gene: htr2a / 100492782
• XenbaseID: XB-GENE-986221
• Length: 483
• Species: Xenopus tropicalis
• Alignment Length: 471
• Identity: 342/471 - (72%)
• Similarity: 391/471 - (83%)
• Gaps: 10/471 - (2%)

Human     1 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC 65
            ||:...:| .::.|.:||:::|.|.|.|.:|..:...|||:..|||:.|||.|:|:.||    |.
 Frog    23 MDLHDNQN-FVNFTKSSLIEINHDRRFYRSDMLATGVNTSEILNWTMASENLTHLTTEG----SK 82

Human    66 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
            .||    ||||.||||..||::|||||||||||||||||||||||||||||||||||||||||||
 Frog    83 FSL----EKNWPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 143

Human   131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195
            |||.||..|.|||..|||.|||||||||||||||||||||||||:||:||||||||||||||..|
 Frog   144 SMLNILNDYEWPLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKALAK 208

Human   196 IIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKS 260
            ||||||||||||||:||||||||||||.:.:|.|:|:||::|||||:|||||.||||||||||||
 Frog   209 IIAVWTISVGISMPVPVFGLQDDSKVFDQENCSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKS 273

Human   261 LQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVL 325
            ||||||||:::||.::|||.||||||||:|||||||||:.:|...| ||:|||||||||||.|||
 Frog   274 LQKEATLCINNLGAKSKLALFSFLPQSSISSEKLFQRSLQKELAPY-GRKTMQSISNEQKASKVL 337

Human   326 GIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390
            ||||||||:|||||||||:|||.|||||||.|||.||.|||||||||||||||||||||:|||||
 Frog   338 GIVFFLFVIMWCPFFITNVMAVFCKESCNEHVIGELLKVFVWIGYLSSAVNPLVYTLFNQTYRSA 402

Human   391 FSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEE 455
            |||||||:|:|.|||||||||||||||||.|||||:.|.|:.|::.|...||.|:|.:|.|..:.
 Frog   403 FSRYIQCRYREEKKPLQLILVNTIPALAYNSSQLQLAQMKSLKKEGKMKTNDYSLVTIGLQPLDR 467

Human   456 ASKDNSDGVNEKVSCV 471
            |||.....:||.|||:
 Frog   468 ASKTGVAPLNENVSCL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR2A	NP_000612.1	7tmA_5-HT2A	75..391	CDD:341345	263/315 (83%)
		TM helix 1	76..102	CDD:341345	20/25 (80%)
		TM helix 2	109..135	CDD:341345	25/25 (100%)
		TM helix 3	148..178	CDD:341345	27/29 (93%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	172..174		1/1 (100%)
		TM helix 4	190..213	CDD:341345	19/22 (86%)
		TM helix 5	231..260	CDD:341345	23/28 (82%)
		TM helix 6	316..346	CDD:341345	26/29 (90%)
		TM helix 7	359..384	CDD:341345	22/24 (92%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	376..380		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..471		8/19 (42%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405	469..471		1/1 (100%)
htr2a	XP_017947163.1	7tm_GPCRs	88..403	CDD:475119	263/315 (83%)
		TM helix 1	90..114	CDD:341345	18/23 (78%)
		TM helix 2	123..145	CDD:341345	21/21 (100%)
		TM helix 3	162..184	CDD:341345	20/21 (95%)
		TM helix 4	207..223	CDD:341345	14/15 (93%)
		TM helix 5	245..268	CDD:341345	17/22 (77%)
		TM helix 6	334..356	CDD:341345	19/21 (90%)
		TM helix 7	371..396	CDD:341345	22/24 (92%)