DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2772 and LIPN

DIOPT Version :9

Sequence 1:	NP_608776.1	Gene:	CG2772 / 33559	FlyBaseID:	FBgn0031533	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	423	Identity:	137/423 - (32%)
Similarity:	207/423 - (48%)	Gaps:	42/423 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLAKVLTILAIVA---SAGAADDFDPFIDI-----PFKRLKTSAERIAEHGYPAESHFVETPDGY 57
            |:..:||...::.   :||.      |:|:     |...:.|| |.|..:|||:|.:.|.|.|||
Human     1 MMWLLLTTTCLICGTLNAGG------FLDLENEVNPEVWMNTS-EIIIYNGYPSEEYEVTTEDGY 58

  Fly    58 VLNVFRIPHSPKLNSNGNEGESEASRPVVLIMHGLFSCSDCFLLNGPEDALPYNYADAGYDVWLG 122
            :|.|.|||:      ......|...||||.:.|.||:.:..:|.|....:|.:..||||||||:|
Human    59 ILLVNRIPY------GRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMG 117

  Fly   123 NARGNIYSRNNTRLNVKHPYFWKFSWHEIGSIDLPATIDYILAETGQQSLHYVGHSQGCTSFFVM 187
            |:|||.:||.:..|:.....||.||:.|:...|||..||:|:.:|||:.|:::|||.|.|..||.
Human   118 NSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVA 182

  Fly   188 GSYRPEYNAKIKTAHMLAPPVYM----GNSTEGLIVSTAPLFGHHGIGSTLLENQVLLPQNAFIQ 248
            .|..||...:||....|.|.:..    |..|...::..:.:....|.....||::.        .
Human   183 FSTMPELAQRIKMNFALGPTISFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKK--------T 239

  Fly   249 RVLDTTCSNQPIMLSYCKTLAILWGGPEIGNLNQTLLPQIAETHPAGVSSNQAIHYIQSYASNDF 313
            ::..|...|..|:...|.....||.|....|:||:.:.......|.|.|.:..:|..|.|.|::|
Human   240 KIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEF 304

  Fly   314 RLYDWGSKR-NLEYYGVSEPPAYDLTKITSELYLYYGLADGSANKQDISRLPDLLPNLALLHE-- 375
            |.||||:.. |:::|..|.||.||||.:.....::.|..|.....||::|   :||.:..||.
Human   305 RAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVAR---ILPQIKSLHYFK 366

  Fly   376 -VPDSTWGHLDFIFATEVKRVINDLVLDYSKAY 407
             :||  |.|.||::..:..:.:...::...|||
Human   367 LLPD--WNHFDFVWGLDAPQRMYSEIIALMKAY 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2772	NP_608776.1	PLN02872	5..393	CDD:215470	133/403 (33%)
		Abhydro_lipase	36..103	CDD:282003	25/66 (38%)
		Abhydrolase	113..>196	CDD:304388	41/82 (50%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	27/67 (40%)
		Abhydrolase_1	79..379	CDD:278959	106/312 (34%)
		Abhydrolase	106..>175	CDD:304388	34/68 (50%)
		Abhydrolase	<149..>234	CDD:304388	27/84 (32%)
		Abhydrolase_5	<322..374	CDD:289465	19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141749
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910