DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2772 and LIPA

DIOPT Version :9

Sequence 1:	NP_608776.1	Gene:	CG2772 / 33559	FlyBaseID:	FBgn0031533	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_000226.2	Gene:	LIPA / 3988	HGNCID:	6617	Length:	399	Species:	Homo sapiens

Alignment Length:	409	Identity:	137/409 - (33%)
Similarity:	208/409 - (50%)	Gaps:	42/409 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLTILAIVASAGAADDFDPFIDIPFKRLKTSAERIAEHGYPAESHFVETPDGYVLNVFRIPHSPK 69
            ||..|....|.|.....||..::      ..:|.|:..|:|:|.:.|||.|||:|.:.||||..|
Human    13 VLWTLHSEGSGGKLTAVDPETNM------NVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRK 71

  Fly    70 LNSNGNEGESEASRPVVLIMHGLFSCSDCFLLNGPEDALPYNYADAGYDVWLGNARGNIYSRNNT 134
            .:|:      :..:|||.:.|||.:.|..::.|....:|.:..||||:|||:||:|||.:||.:.
Human    72 NHSD------KGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHK 130

  Fly   135 RLNVKHPYFWKFSWHEIGSIDLPATIDYILAETGQQSLHYVGHSQGCTSFFVMGSYRPEYNAKIK 199
            .|:|....||.||:.|:...||||:|::||.:|||:.::|||||||.|..|:..|..||...:||
Human   131 TLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIK 195

  Fly   200 ----------TAHMLAPPVYMGNSTEGLIVSTAPLFGHHGIGSTLLENQVLLPQNAFIQRVLDTT 254
                      .|...:|...:|...:.||   ..|||          ::..|||:||: :.|.|.
Human   196 MFFALGPVASVAFCTSPMAKLGRLPDHLI---KDLFG----------DKEFLPQSAFL-KWLGTH 246

  Fly   255 CSNQPIMLSYCKTLAILWGGPEIGNLNQTLLPQIAETH-PAGVSSNQAIHYIQSYASNDFRLYDW 318
            .....|:...|..|..|..|....|||.:.: .:..|| |||.|....:|:.|:.....|:.:||
Human   247 VCTHVILKELCGNLCFLLCGFNERNLNMSRV-DVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDW 310

  Fly   319 GSK-RNLEYYGVSEPPAYDLTKITSELYLYYGLADGSANKQDISRLPDLLPNLALLHEVPDSTWG 382
            ||. :|..:|..|.||.|::..:.....::.|..|..|:..|::.|...:.||.....:|:  |.
Human   311 GSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPE--WE 373

  Fly   383 HLDFIFATEVK-RVINDLV 400
            |||||:..:.. |:.|.::
Human   374 HLDFIWGLDAPWRLYNKII 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2772	NP_608776.1	PLN02872	5..393	CDD:215470	135/399 (34%)
		Abhydro_lipase	36..103	CDD:282003	25/66 (38%)
		Abhydrolase	113..>196	CDD:304388	43/82 (52%)
LIPA	NP_000226.2	PLN02872	38..396	CDD:215470	130/378 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141793
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810