DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2772 and LIPJ

DIOPT Version :9

Sequence 1:	NP_608776.1	Gene:	CG2772 / 33559	FlyBaseID:	FBgn0031533	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001010939.2	Gene:	LIPJ / 142910	HGNCID:	21773	Length:	366	Species:	Homo sapiens

Alignment Length:	369	Identity:	119/369 - (32%)
Similarity:	190/369 - (51%)	Gaps:	20/369 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IAEHGYPAESHFVETPDGYVLNVFRIPHSPKLNSNGNEGESEASRPVVLIMHGLFSCSDCFLLNG 103
            |:..|||.|.:.:.|.|||:|.::|||:. :.::|.|    .|.|.||.:.|||.:.:..::.|.
Human     7 ISYWGYPDEEYDIVTEDGYILGLYRIPYW-RTDNNKN----LAQRVVVYLQHGLLTSASSWISNL 66

  Fly   104 PEDALPYNYADAGYDVWLGNARGNIYSRNNTRLNVKHPYFWKFSWHEIGSIDLPATIDYILAETG 168
            |.::|.:..||||||||:||:|||.:||.:..|......||.||:.|:...||||:||:.:.:|.
Human    67 PNNSLGFILADAGYDVWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFTVKQTR 131

  Fly   169 QQSLHYVGHSQGCTSFFVMGSYRPEYNAKIKTAHMLAPPVYMGNSTEGLIVSTAPL----FGHHG 229
            |:.:.|||||||.|..|:..|...:...:||....|| ||:   ||:.|   .:||    :....
Human   132 QEEIFYVGHSQGTTIGFITFSTISKIAERIKIFFALA-PVF---STKYL---KSPLIRMTYKWKS 189

  Fly   230 IGSTLLENQVLLPQNAFIQRVLDTTCSNQPIMLSYCKTLAILWGGPEIGNLNQTLLPQIAETHPA 294
            |......|:..||:.:|.:.:....|..| |....|..:..:..|.:..|||.:.|......:||
Human   190 IVMAFSGNKDFLPKTSFKKFIGSKLCPLQ-IFDKICLNILFMMFGYDPKNLNMSRLDVYFSHNPA 253

  Fly   295 GVSSNQAIHYIQSYASNDFRLYDWGS-KRNLEYYGVSEPPAYDLTKITSELYLYYGLADGSANKQ 358
            |.|....:|:.|...|...:.||||| ..||.:|..:..|.|::|.:.....::.|.:|..|:.:
Human   254 GTSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQTTSPLYNMTNMNVATAIWNGKSDLLADPE 318

  Fly   359 DISRLPDLLPNLALLHEVPDSTWGHLDFIFATEVKRVINDLVLD 402
            |::.|...:.|......:  |.:.|:|.:|..:|...:...::|
Human   319 DVNILHSEITNHIYYKTI--SYYNHIDSLFGLDVYDQVYHEIID 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2772	NP_608776.1	PLN02872	5..393	CDD:215470	117/358 (33%)
		Abhydro_lipase	36..103	CDD:282003	22/63 (35%)
		Abhydrolase	113..>196	CDD:304388	39/82 (48%)
LIPJ	NP_001010939.2	Abhydro_lipase	3..66	CDD:282003	22/63 (35%)
		Abhydrolase_5	47..209	CDD:289465	63/168 (38%)
		Abhydrolase_1	48..347	CDD:278959	99/308 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141760
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910