DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant2 and galnt16

DIOPT Version :9

Sequence 1:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	XP_001339749.3	Gene:	galnt16 / 799387	ZFINID:	ZDB-GENE-131120-189	Length:	567	Species:	Danio rerio

Alignment Length:	639	Identity:	294/639 - (46%)
Similarity:	392/639 - (61%)	Gaps:	90/639 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRRNIK--LIVFVSIIWMFVMVYYFQSSTEKVENRALRLREVATAMQQYQDDSSSAAAASTARQW 63
            |.|.|:  .|:.:::.|:....||.                       :||...||:::|
Zfish     1 MMRRIRANAILILTVAWILGTFYYL-----------------------WQDSKPSASSSS----- 37

  Fly    64 APAGGGAGPGAAAGAAGSGADDPGGNVILIGSVKDFERNAVHGLKLNGIVALEETSQGLSGGTGG 128
                      :::.:|||                   :..:||.| :....|||.:
Zfish    38 ----------SSSSSAGS-------------------QQKIHGQK-SSSGRLEERT--------- 63

  Fly   129 PGGRLPV----AP--SGRGTEVEYFNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIPDT 187
                ||:    ||  ..:|..:..|:|..::.:..||.|||||..:.||.:.||.|.|.|.|.||
Zfish    64 ----LPLIVTRAPQLEQQGQLLGLFDEKAFLSSKQLRPGEDPYREHAFNLQESDRLGSERAIRDT 124

  Fly   188 RNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLE 252
            |:..|.:..:..|||.||:||||||||||||||||.|||.|||.|||.||:||||:|..|||...
Zfish   125 RHYRCASMTFDPDLPPTSIIITFHNEARSTLLRTIKSVLMRSPPHLILEIILVDDFSSDPEDCRL 189

  Fly   253 LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCP 317
            |::|.|||.:||::||||:||||:||.||.:|:|||||||.|.|..||:|:::||:||.:|||.|
Zfish   190 LSQIPKVRCLRNERREGLIRSRVRGASAASASILTFLDSHCEVNTDWLQPMIQRVKEDHSRVVSP 254

  Fly   318 VIDVISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKA 382
            :|||||:|||.|:.|||||||||||:|.||||.: |.|:.|..||||..||||:||||:|||:|.
Zfish   255 IIDVISLDNFAYLAASADLRGGFDWSLHFKWEQI-PIEQKMARNDPTQPIRTPVIAGGIFVIEKG 318

  Fly   383 YFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNT 447
            :||.||:||..||:|||||.|:|||||.|||||||:|||||||||||||||.||.|:...:.:||
Zfish   319 WFNHLGQYDTHMDIWGGENFELSFRVWMCGGSLEILPCSRVGHVFRKRHPYDFPEGNALTYIKNT 383

  Fly   448 RRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEVG 512
            |||||||||||||:||.|.|.|:...||:|.||||||.||:|..|:||||||||:|:.|:.:|..
Zfish   384 RRAAEVWMDDYKQYYYAARPSAQGKAFGSIADRLALKRKLNCNSFRWYLENVYPELKIPEQEEAY 448

  Fly   513 QFRQDSTECLDTMGHLIDGTVGIFPCHNT---GGNQEWAFTKRGEIKHDDLCLTLVTFARGSQVV 574
            ...:....||::.|   ..::|:..|.:|   ..:|:|...: .:|:..||||.:..|..||:|.
Zfish   449 SLLKQGGLCLESHG---TDSLGLAECRSTPSIPASQKWTLIE-PQIRQHDLCLAITAFTAGSKVR 509

  Fly   575 LKACDDSEN-QRWIMREGGLVRHYKINVCLDSRDQSQQGVSAQHCNSALGTQRW 627
            |:.|:..|: |:|..| |..::|....:||||:..|.....|| |...:.:|.|
Zfish   510 LEPCNIKESRQKWKPR-GPALQHMISGLCLDSQPPSGPPAIAQ-CRPQVASQSW 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	162/231 (70%)
		pp-GalNAc-T	205..500	CDD:133004	202/294 (69%)
		Ricin_B_lectin	511..627	CDD:279046	34/119 (29%)
		RICIN	513..629	CDD:238092	35/119 (29%)
galnt16	XP_001339749.3	Glyco_tranf_2_3	139..365	CDD:290369	157/226 (69%)
		pp-GalNAc-T	142..436	CDD:133004	202/294 (69%)
		Ricin_B_lectin	452..561	CDD:279046	34/114 (30%)
		RICIN	455..562	CDD:238092	35/113 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351893at33208
OrthoFinder	1	1.000	-	-		FOG0001204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2085
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820