Protein Alignment Pgant2 and GALNT12

DIOPT Version :10

• Sequence 1: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_078918.3
• Gene: GALNT12 / 79695
• HGNCID: 19877
• Length: 581
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 237/567 - (41%)
• Similarity: 333/567 - (58%)
• Gaps: 62/567 - (10%)

  Fly   107 LKLNGIVALEETSQGLSGG--------TGGPGGRLPVAP---------SGRGTEVEYFNEAGYIR 154
            |.|.|:.::....:|...|        |..||.|.||.|         ..||..|..     .::
Human    28 LALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRL-----QLQ 87

  Fly   155 AGALRNGEDPYIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYRED-LPETSVIITFHNEARSTL 218
            ...||..|:....::.|...||.:..:|.:|:..||:|:.|||..| ||.|||||.|:|||.|||
Human    88 GEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTL 152

  Fly   219 LRTIVSVLNRSPEHLIREIVLVDDYSD--HPEDGL--ELAKIDKVRVIRNDKREGLVRSRVKGAD 279
            |||:.|||..||:.|:.|::|||||||  |.::.|  ||:.:.|||:||.:|||||||:|:.||.
Human   153 LRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGAS 217

  Fly   280 AAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDVISMDNFQYIGASADLR-GGFDWN 343
            ||...||||||.|.||:|.||||||:|:.|:.:.|||||||||..:.|:|:|.|.:.: |||||.
Human   218 AARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWR 282

  Fly   344 LIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDMKMDVWGGENLEISFRV 408
            |:|.|..:...|| :|...|...||:|.:|||||.:.|.||..||.||..|:||||||||.|||:
Human   283 LVFTWHTVPERER-IRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRI 346

  Fly   409 WQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRAAEVWMDDYKQHYYNAVPLAKNIP 473
            |||||.||..|||.|||||.|:.||     |.|....|:.||||||||::|:.||:..|.|:..|
Human   347 WQCGGVLETHPCSHVGHVFPKQAPY-----SRNKALANSVRAAEVWMDEFKELYYHRNPRARLEP 406

  Fly   474 FGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPD--PQEVGQFRQD--STECLD--------TMG 526
            ||::.:|..|::||.||.|||:||.|||:|..|:  |...|..:..  :..|.|        .:|
Human   407 FGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVG 471

  Fly   527 HLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHD----DLCLTLVTFARGSQVVLKACDDS--ENQR 585
            |    .|.::.||..|.||.:.:|.:.||:::    :.|:.:.  |....:::..|:::  |||:
Human   472 H----QVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVE--AGMDTLIMHLCEETAPENQK 530

  Fly   586 WIMREGGLVRHYKINVCLDS--RDQSQQGVS-AQHCNSALGTQRWSF 629
            :|::|.|.:.|.:...|:.:  ::.|...|. .:.|.:: ..|:|.|
Human   531 FILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNS-DHQKWFF 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	167/299 (56%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	30/137 (22%)
GALNT12	NP_078918.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..67		7/23 (30%)
		Catalytic subdomain A	135..244		68/108 (63%)
		pp-GalNAc-T	139..433	CDD:133004	167/299 (56%)
		Catalytic subdomain B	304..366		41/61 (67%)
		beta-trefoil_Ricin_GALNT12	443..579	CDD:467349	32/141 (23%)